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Dysregulated Repeat Element Viral-like Immune Response in Hepatocellular Carcinoma.

Autor: Coley AK; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA.; Department of Surgery, Massachusetts General Hospital Harvard Medical School; Boston, MA, USA., Lu C; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA.; Health Sciences and Technology Program; Cambridge, MA, USA., Pankaj A; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA., Emmett MJ; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School; Boston, MA, USA., Lang ER; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA., Song Y; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA., Xu KH; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA., Xu N; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA., Patel BK; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA., Chougule A; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA., Nieman LT; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA., Aryee MJ; Department of Biostatistics, Harvard T.H. Chan School of Public Health; Boston, MA, USA.; Department of Data Sciences, Dana-Farber Cancer Institute; Boston, MA, USA.; Broad Institute of Harvard and MIT; Cambridge, MA, USA., Ferrone CR; Department of Surgery, Cedars-Sinai Hospital; Los Angeles, CA, USA., Deshpande V; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School; Boston, MA, USA., Franses JW; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School; Boston, MA, USA.; Health Sciences and Technology Program; Cambridge, MA, USA.; Section of Hematology-Oncology, Department of Medicine, University of Chicago; Chicago, IL, USA., Ting DT; Mass General Cancer Center, Harvard Medical School; Charlestown, MA, USA.; Department of Medicine, Massachusetts General Hospital, Harvard Medical School; Boston, MA, USA.; Health Sciences and Technology Program; Cambridge, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 05. Date of Electronic Publication: 2023 Dec 05.

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Linker histone variant H1t is closely associated with repressed repeat-element chromatin domains in pachytene spermatocytes

Autor: Iyer Aditya Mahadevan, Sanjeev Kumar, Manchanahalli R. Satyanarayana Rao

Publikováno v: Epigenetics & Chromatin, Vol 13, Iss 1, Pp 1-19 (2020)

Abstract Background H1t is the major linker histone variant in pachytene spermatocytes, where it constitutes 50–60% of total H1. This linker histone variant was previously reported to localize in the nucleolar rDNA element in mouse spermatocytes. O

Externí odkaz: https://doaj.org/article/c699e373b4354077b7b1846b97c83761

Properties of LINE-1 proteins and repeat element expression in the context of amyotrophic lateral sclerosis

Autor: Gavin C. Pereira, Laura Sanchez, Paul M. Schaughency, Alejandro Rubio-Roldán, Jungbin A. Choi, Evarist Planet, Ranjan Batra, Priscilla Turelli, Didier Trono, Lyle W. Ostrow, John Ravits, Haig H. Kazazian, Sarah J. Wheelan, Sara R. Heras, Jens Mayer, Jose Luis García-Pérez, John L. Goodier

Publikováno v: Mobile DNA, Vol 9, Iss 1, Pp 1-30 (2018)

ABSTRACT Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving loss of motor neurons and having no known cure and uncertain etiology. Several studies have drawn connections between altered retrotransposon expre

Externí odkaz: https://doaj.org/article/4c05b9012a7d41358fb9b99446dd09e9