Zobrazeno 1 - 10
of 2 012
pro vyhledávání: '"Repair gene"'
Autor:
Xiaojing Liu, Haiqing Zhu, Bao Guo, Jiahua Chen, Junhui Zhang, Tao Wang, Jing Zhang, Wenjun Shan, Junchi Zou, Yunxia Cao, Bing Wei, Lei Zhan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The innate immune molecule NLR family CARD domain-containing 5 (NLRC5) plays a significant role in endometrial carcinoma (EC) immunosurveillance. However, NLRC5 also plays a protumor role in EC cells. Mismatch repair gene deficiency (dMMR) c
Externí odkaz:
https://doaj.org/article/41ec07cd9fba40bda73fd4db7857a8d0
Autor:
Zijian Deng, Yajun Luo, Xiaoli Chen, Tao Pan, Yuanyi Rui, Hai Hu, Jin Yan, Ke Zhang, Cheng Luo, Bo Song
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundIn recent years, there has been significant research interest in immunotherapy for colorectal cancer (CRC). Specifically, immunotherapy has emerged as the primary treatment for patients with mismatch repair gene defects (dMMR) or microsatel
Externí odkaz:
https://doaj.org/article/fe3d5d3a186a413497a4c9e1e9ef5771
Autor:
Chiara Casadei, Emanuela Scarpi, Vincenza Conteduca, Giorgia Gurioli, Maria Concetta Cursano, Nicole Brighi, Cristian Lolli, Giuseppe Schepisi, Umberto Basso, Giuseppe Fornarini, Sara Bleve, Alberto Farolfi, Amelia Altavilla, Salvatore Luca Burgio, Emilio Francesco Giunta, Caterina Gianni, Alessia Filograna, Paola Ulivi, David Olmos, Elena Castro, Ugo De Giorgi
Publikováno v:
European Urology Open Science, Vol 61, Iss , Pp 44-51 (2024)
Background: The prevalence of pathogenic germline mutations in DNA damage repair (gDDR) genes in the Italian population is unknown. Objective: In this prospective multicenter cohort study, we evaluated the prevalence of gDDR alterations in the Italia
Externí odkaz:
https://doaj.org/article/da61ee9b940b4381ac3aa92030e5b551
Autor:
Tiansong Zhang, Xiaoqiang Huang, Wenjie Liu, Xiulan Ling, Zhenping Su, Mengwei Huang, Shuanlong Che
Publikováno v:
Diagnostic Pathology, Vol 19, Iss 1, Pp 1-8 (2024)
Abstract Background Multiple primary malignancies are rare in cancer patients, and risk factors may include genetics, viral infection, smoking, radiation, and other environmental factors. Lynch syndrome (LS) is the most prevalent form of hereditary p
Externí odkaz:
https://doaj.org/article/534f5e82f93f4ec5b034a2ea200c8f07
Autor:
Vittorio Fasulo, NicolòMaria Buffi, Giuseppe Chiarelli, Giovanni Lughezzani, Monica Zuradelli, Carla Barbara Ripamonti, Monica Barile, Paolo Bianchi, Alessio Benetti, Marco Paciotti, Alessandro Uleri, Pier Paolo Avolio, Alberto Saita, Rodolfo Hurle, Federica Maura, Luca Germagnoli, Rosanna Asselta, Giulia Soldà, Paolo Casale, Massimo Lazzeri
Publikováno v:
BJUI Compass, Vol 4, Iss 6, Pp 738-745 (2023)
Abstract Abstract Objective The aim of this study is to evaluate male awareness of developing prostate cancer (PCa) in families with germline DNA‐repair genes (DRG) variants. Materials and methods Data were collected from a prospective, monocentric
Externí odkaz:
https://doaj.org/article/b30c2e8d220847e08e10748f34ce0a6e
Autor:
Ehsan Zarei, Iraj Saadat
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 24, Iss 1, Pp 1-7 (2023)
Abstract Background Cancer results from the accumulation of mutations in critical genes, such as DNA repair genes. But these genes are a double-edged sword, because the basis of current cancer treatment is DNA damage from chemotherapy and radiation,
Externí odkaz:
https://doaj.org/article/78cbeb75a5e54c62a0fbc47d2443f848
Publikováno v:
Middle East Journal of Cancer, Vol 14, Iss 2, Pp 300-308 (2023)
Lynch syndrome (LS) predisposes individuals to early-onset colorectal and other Lynch-associated cancer. This disorder is an autosomal dominant genetic disturbance caused by germline mutations in one of the mismatch repair genes. Different clinical a
Externí odkaz:
https://doaj.org/article/61c4ec0402ba4e588bbc747f4ffab19b
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
ObjectiveThe efficacy of platinum-based chemotherapy (PtCh) for pancreatic cancer (PC) patients with DNA damage repair gene mutations (DDRm) compared to those without DDRm remains uncertain.MethodsAfter a thorough database searching in PubMed, Embase
Externí odkaz:
https://doaj.org/article/6a1ea456bc9e46289e1278df212b6512
Publikováno v:
Xiehe Yixue Zazhi, Vol 14, Iss 1, Pp 190-195 (2023)
Lynch syndrome (LS), an autosomal dominant genetic disorder caused by mismatch repair gene defects, is characterized by the susceptibility to multi-system malignancies. LS associated endometrial cancer (LS-EC) is the most common extraintestinal senti
Externí odkaz:
https://doaj.org/article/c4bf80f164c141a1b436e6070cd8b319
Publikováno v:
Global Medical Genetics, Vol 10, Iss 01, Pp 001-005 (2023)
Background Lynch syndrome (LS) is an autosomal dominant condition due to the germline mutation in the mismatch repair (MMR) genes including MLH1, MSH2, MSH6, and PMS2 (post-meiotic segregation increased 2). The MMR mutation carriers have high risk fo
Externí odkaz:
https://doaj.org/article/ff247c6dc8c14d4596d3d1046332de02