Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Reo Yasuma"'
Autor:
Bradley D. Gelfand, Charles B. Wright, Younghee Kim, Tetsuhiro Yasuma, Reo Yasuma, Shengjian Li, Benjamin J. Fowler, Ana Bastos-Carvalho, Nagaraj Kerur, Annette Uittenbogaard, Youn Seon Han, Dingyuan Lou, Mark E. Kleinman, W. Hayes McDonald, Gabriel Núñez, Philippe Georgel, Joshua L. Dunaief, Jayakrishna Ambati
Publikováno v:
Cell Reports, Vol 11, Iss 11, Pp 1686-1693 (2015)
Excess iron induces tissue damage and is implicated in age-related macular degeneration (AMD). Iron toxicity is widely attributed to hydroxyl radical formation through Fenton’s reaction. We report that excess iron, but not other Fenton catalytic me
Externí odkaz:
https://doaj.org/article/978a1cd998d14ea7902ee02655f15e7f
Autor:
Shuichiro Hirahara, Tetsuro Oshika, Siddharth Narendran, J. Ignacio Aguirre, Shinichi Fukuda, Meenakshi Ambati, Benjamin J. Fowler, Praveen Yerramothu, Bradley D. Gelfand, David R. Hinton, Jayakrishna Ambati, Gerald G. Schumann, Ulrike Held, Yosuke Nagasaka, Felipe Pereira, Kirstie Baker, Nagaraj Kerur, Srinivas R. Sadda, Sanford H. Feldman, Shaobin Wang, Akhil Varshney, Peirong Huang, Ryan D. Makin, Kameshwari Ambati, Vera L. Bonilha, Mo Wang, Tetsuhiro Yasuma, Reo Yasuma, Vidya L. Ambati, Elmira Baghdasaryan, Xiwen Huang, Hiroko Terasaki, Daipayan Banerjee, Ivana Apicella, Kenneth M. Marion, Genrich V. Tolstonog, Yuichiro Ogura, Deepak Bhattarai, Kyung Bo Kim
Publikováno v:
Science advances, 7(40):eabj3658
Science Advances
Science advances, vol. 7, no. 40, pp. eabj3658
Science Advances
Science advances, vol. 7, no. 40, pp. eabj3658
Description
Endogenous Alu cDNA triggers inflammasome-mediated cell death in age-related macular degeneration.
Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA
Endogenous Alu cDNA triggers inflammasome-mediated cell death in age-related macular degeneration.
Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee76950f2faadbc056f974ac06c1a507
https://doi.org/10.1126/sciadv.abj3658
https://doi.org/10.1126/sciadv.abj3658
Autor:
Shinichi, Fukuda, Akhil, Varshney, Benjamin J, Fowler, Shao-Bin, Wang, Siddharth, Narendran, Kameshwari, Ambati, Tetsuhiro, Yasuma, Joseph, Magagnoli, Hannah, Leung, Shuichiro, Hirahara, Yosuke, Nagasaka, Reo, Yasuma, Ivana, Apicella, Felipe, Pereira, Ryan D, Makin, Eamonn, Magner, Xinan, Liu, Jian, Sun, Mo, Wang, Kirstie, Baker, Kenneth M, Marion, Xiwen, Huang, Elmira, Baghdasaryan, Meenakshi, Ambati, Vidya L, Ambati, Akshat, Pandey, Lekha, Pandya, Tammy, Cummings, Daipayan, Banerjee, Peirong, Huang, Praveen, Yerramothu, Genrich V, Tolstonog, Ulrike, Held, Jennifer A, Erwin, Apua C M, Paquola, Joseph R, Herdy, Yuichiro, Ogura, Hiroko, Terasaki, Tetsuro, Oshika, Shaban, Darwish, Ramendra K, Singh, Saghar, Mozaffari, Deepak, Bhattarai, Kyung Bo, Kim, James W, Hardin, Charles L, Bennett, David R, Hinton, Timothy E, Hanson, Christian, Röver, Keykavous, Parang, Nagaraj, Kerur, Jinze, Liu, Brian C, Werner, S Scott, Sutton, Srinivas R, Sadda, Gerald G, Schumann, Bradley D, Gelfand, Fred H, Gage, Jayakrishna, Ambati
Publikováno v:
Proc Natl Acad Sci U S A
Alu retroelements propagate via retrotransposition by hijacking long interspersed nuclear element-1 (L1) reverse transcriptase (RT) and endonuclease activities. Reverse transcription of Alu RNA into complementary DNA (cDNA) is presumed to occur exclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62beeef8e70aaaf560f034ebc5905abf
https://pubmed.ncbi.nlm.nih.gov/33526699
https://pubmed.ncbi.nlm.nih.gov/33526699
Autor:
Vidya L. Ambati, Mo Wang, Kyung Bo Kim, Joseph R. Herdy, Siddharth Narendran, Yuichiro Ogura, Bradley D. Gelfand, Eamonn Magner, Jayakrishna Ambati, Apuã C. M. Paquola, Christian Röver, Benjamin J. Fowler, Timothy Hanson, Meenakshi Ambati, Lekha Pandya, Ramendra K. Singh, Yosuke Nagasaka, Kirstie Baker, Jian Sun, James W. Hardin, Jinze Liu, Reo Yasuma, Charles L. Bennett, Genrich V. Tolstonog, Deepak Bhattarai, Praveen Yerramothu, Akshat Pandey, Daipayan Banerjee, Tetsuro Oshika, Gerald G. Schumann, Xinan Liu, Srinivas R. Sadda, Kameshwari Ambati, Tammy H. Cummings, Shaban Darwish, Akhil Varshney, Keykavous Parang, Saghar Mozaffari, Ryan D. Makin, Peirong Huang, Kenneth M. Marion, Elmira Baghdasaryan, Shaobin Wang, Hannah Leung, Brian C. Werner, Jennifer A. Erwin, Nagaraj Kerur, Xiwen Huang, Hiroko Terasaki, Felipe Pereira, S Scott Sutton, Shuichiro Hirahara, David R. Hinton, Ulrike Held, Joseph Magagnoli, Shinichi Fukuda, Ivana Apicella, Fred H. Gage, Tetsuhiro Yasuma
Publikováno v:
Proceedings of the National Academy of Sciences. 118
Significance Alu elements, comprising more than 10% of the human genome, propagate via retrotransposition. This genomic expansion requires enzymatic activity of L1 that reverse transcribes Alu RNA into Alu cDNA in the nucleus. We report Alu also unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::faab56470358e690f442ac6be149dcb9
https://doi.org/10.1073/pnas.2022751118
https://doi.org/10.1073/pnas.2022751118
Autor:
Bradley D. Gelfand, Nagaraj Kerur, Yosuke Nagasaka, Ambati Balamurali K, Shinichi Fukuda, Jayakrishna Ambati, Charles B. Wright, Benjamin J. Fowler, Bo Chang, Tetsuhiro Yasuma, Siddharth Narendran, Izuho Hatada, Reo Yasuma, Philippe Georgel, Ana Bastos-Carvalho, Felipe Pereira, Romulo Albuquerque, Younghee Kim, Shuichiro Hirahara, Ivana Apicella, Hironori Uehara, Ryan D. Makin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance DICER1 processes micro-RNAs into their bioactive forms and metabolizes RNAs from short interspersed nuclear element genetic repeats, principally Alu RNAs in humans. DICER1 deficiency is implicated in retinal pigmented epithelium (RPE) de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29a87b487442fdc8a37ed197e2b940e
https://pubmed.ncbi.nlm.nih.gov/31964819
https://pubmed.ncbi.nlm.nih.gov/31964819
Autor:
Nagaraj Kerur, S. Michal Jazwinski, John C. Cambier, Katherine A. Fitzgerald, Tetsuhiro Yasuma, Shinichi Fukuda, Vidya L. Ambati, Reo Yasuma, Isao Hara, Jayakrishna Ambati, Srinivas R. Sadda, Ivana Apicella, Tetsuro Oshika, Bradley D. Gelfand, Meenakshi Ambati, Kyung Bo Kim, Elmira Baghdasaryan, Hiroshi Nagai, Yuichiro Ogura, Akhil Varshney, Yuji Kajiwara, Dongxu Fu, Norbert Leitinger, A. Phillip West, Kameshwari Ambati, Yoshio Hirano, Kenneth M. Marion, Daipayan Banerjee, Benjamin J. Fowler, Joseph D. Buxbaum, Vlad Serbulea, Younghee Kim, Hiroko Terasaki, Xiwen Huang, Ana Bastos-Carvalho, David R. Hinton, M. Cristina Kenney, Shuichiro Hirahara
Publikováno v:
Nature medicine
Geographic atrophy is a blinding form of age-related macular degeneration characterized by death of the retinal pigmented epithelium (RPE). In this disease, the RPE displays evidence of DICER1 deficiency, resultant accumulation of endogenous Alu retr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fae00b0f6a316123b3648987eee4ba
http://europepmc.org/articles/PMC5760363
http://europepmc.org/articles/PMC5760363
Autor:
Reo Yasuma, Tetsushi Yasuma
Publikováno v:
Journal of Clinical & Experimental Ophthalmology.
Objective: In most eye clinics, while severe to moderate color vision defects are diagnosed with the Farnsworth dichotomous test D-15 (D-15 test), moderate to mild color vision defects are detected with the Farnsworth lantern test. This study aims to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a71551bbcc388a1b290965c8441e8905
https://doi.org/10.4172/2155-9570.1000717
https://doi.org/10.4172/2155-9570.1000717
Autor:
Mark E. Kleinman, Charles B. Wright, Younghee Kim, Bradley D. Gelfand, Nagaraj Kerur, Shengjian Li, Philippe Georgel, Ana Bastos-Carvalho, Youn Seon Han, Dingyuan Lou, Joshua L. Dunaief, W. Hayes McDonald, Tetsuhiro Yasuma, Annette Uittenbogaard, Benjamin J. Fowler, Gabriel Núñez, Jayakrishna Ambati, Reo Yasuma
Publikováno v:
Cell Reports, Vol 11, Iss 11, Pp 1686-1693 (2015)
Excess iron induces tissue damage and is implicated in age-related macular degeneration (AMD). Iron toxicity is widely attributed to hydroxyl radical formation through Fenton's reaction. We report that excess iron, but not other Fenton catalytic meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02769bd9d79ddbc7928fb3c40e44bcc
http://www.sciencedirect.com/science/article/pii/S2211124715005495
http://www.sciencedirect.com/science/article/pii/S2211124715005495
Autor:
David R. Hinton, Shoba Amarnath, Takeshi Mizutani, Bradley D. Gelfand, Ana Bastos-Carvalho, Benjamin J. Fowler, Hitesh K. Agarwal, Valeria Tarallo, Charles B. Wright, Reo Yasuma, Shengjian Li, Marta Radwan, Nagaraj Kerur, Paul Kubes, Tetsuhiro Yasuma, Younghee Kim, Keykavous Parang, Keir Pittman, Yoshio Hirano, Jayakrishna Ambati, Daniel H. Fowler, Mark T. Young
Publikováno v:
Science. 346:1000-1003
Nucleoside reverse transcriptase inhibitors (NRTIs) are mainstay therapeutics for HIV that block retrovirus replication. Alu (an endogenous retroelement that also requires reverse transcriptase for its life cycle)–derived RNAs activate P2X7 and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f736576fed3d0d5685c678c1685e699
https://doi.org/10.1126/science.1261754
https://doi.org/10.1126/science.1261754
Autor:
Wright, Charles B., Uehara, Hironori, Kim, Younghee, Tetsuhiro Yasuma, Reo Yasuma, Hirahara, Shuichiro, Makin, Ryan D., Apicella, Ivana, Pereira, Felipe, Nagasaka, Yosuke, Narendran, Siddharth, Fukuda, Shinichi, Albuquerque, Romulo, Fowler, Benjamin J., Bastos-Carvalho, Ana, Georgel, Philippe, Hatada, Izuho, Bo Chang, Kerur, Nagaraj, Ambati, Balamurali K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 2/4/2020, Vol. 117 Issue 5, p2579-2587, 9p