Hot of the breath: mortality as a primary end-point in IPF treatment trials: the best is the enemy of the good

Autor: Wells, Au, Behr, J, Costabel, U, Cottin, V, Poletti, V, Richeldi, L, Albera, C, Ancochea, J, Antoniou, Km, Bonella, F, Bonniaud, P, Bouros, D, Bresser, P, Cordier, Jf, Crestani, B, Domagala Kulawik, J, Drent, M, Egan, Jj, Geiser, T, Grunewald, J, Grutters, J, Gudmundsson, G, Guenther, A, Harai, S, Harrison, Nk, Hirani, N, Hodgson, U, Kahler, Cm, Keane, Mp, Kiter, G, Kneussl, M, Maher, Tm, Mogulkoc, N, Muller Quernheim, J, Neurohr, C, Nunes, H, Parfrey, H, Peros Golubicic, T, Polychronopoulos, V, Prevot, G, Renzoni, Er, Robalo Cordeiro, C, Saltini, C, Skold, M, Spagnolo, P, Thomeer, M, Tomasseti, S, Valeyre, D, Vancheri, Carlo, Wallaert, B, Wuyts, W, Xaubet, A.

The problem of the selection of accurate primary end-points for treatment studies in idiopathic pulmonary fibrosis (IPF) has recently been aired in a controversial paper from the USA.1 The limitations of current end-points are discussed and the autho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4a9c2f9002868424f45287d9ca1bd3
https://hdl.handle.net/11380/1063599

Bacterial burden in the lower airways predicts disease progression in idiopathic pulmonary fibrosis and is independent of radiological disease extent.

Autor: Invernizzi R; National Heart and Lung Institute, Imperial College London, London, UK.; Contributed equally as first authors., Barnett J; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton Hospital, London, UK.; Contributed equally as first authors., Rawal B; Royal Brompton Hospital, London, UK., Nair A; Dept of Radiology, University College Hospital, London, UK., Ghai P; National Heart and Lung Institute, Imperial College London, London, UK., Kingston S; National Heart and Lung Institute, Imperial College London, London, UK., Chua F; Royal Brompton Hospital, London, UK., Wu Z; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton Hospital, London, UK., Wells AU; Royal Brompton Hospital, London, UK., Renzoni ER; Royal Brompton Hospital, London, UK., Nicholson AG; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton Hospital, London, UK., Rice A; Royal Brompton Hospital, London, UK., Lloyd CM; National Heart and Lung Institute, Imperial College London, London, UK., Byrne AJ; National Heart and Lung Institute, Imperial College London, London, UK., Maher TM; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton Hospital, London, UK., Devaraj A; National Heart and Lung Institute, Imperial College London, London, UK.; Royal Brompton Hospital, London, UK., Molyneaux PL; National Heart and Lung Institute, Imperial College London, London, UK p.molyneaux@imperial.ac.uk.; Royal Brompton Hospital, London, UK.

Publikováno v: The European respiratory journal [Eur Respir J] 2020 Apr 03; Vol. 55 (4). Date of Electronic Publication: 2020 Apr 03 (Print Publication: 2020).