Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Renzo Bazzo"'
Autor:
Cristina Gardelli, Uwe Koch, Odalys Gonzalez-Paz, Barbara Pacini, Claudio Giuliano, Renzo Bazzo, Vincenzo Pucci, Joseph F. Leone, Kenneth A. Koeplinger, Michael Rowley, Frank Narjes, Sergio Altamura, Fabrizio Fiore, Malte Meppen, Ralph Laufer, Annalise Di Marco
Publikováno v:
European Journal of Medicinal Chemistry. 44:3765-3770
The currently approved treatment for hepatitis C virus infections is a combination of Ribavirin and pegylated Interferon. It leads to a sustained virologic response in approximately only half of the patients treated. For this reason there is an urgen
Autor:
Elizabeth Chen Dodson, Janet Lineberger, Adam J. Simon, Ming-Tain Lai, Mohinder K. Sardana, Beth Pietrak, Katherine Tugusheva, Berta Strulovici, Amy S. Espeseth, Xiao-Ping Shi, Guoxin Wu, Qian Huang, Renzo Bazzo, Ming-Chih Crouthamel, Eric A. Price, Abigail Wolfe, Yue-Ming Li, Daria J. Hazuda, Marc Ferrer, Jones Kristen L G, Paul Zuck, Craig A. Coburn, Min Xu
Publikováno v:
Journal of Biological Chemistry. 280:17792-17797
Extracellular deposits of aggregated amyloid-beta (Abeta) peptides are a hallmark of Alzheimer disease; thus, inhibition of Abeta production and/or aggregation is an appealing strategy to thwart the onset and progression of this disease. The release
Autor:
Gennaro Ciliberto, Renzo Bazzo, Michael D. Miller, John W. Shiver, Riccardo Cortese, William Hurni, Elisabetta Bianchi, Paolo Ingallinella, Gaetano Barbato, Antonello Pessi
Publikováno v:
Journal of Molecular Biology. 330:1101-1115
Inhibition of human immunodeficiency virus (HIV) fusion with the host cell has emerged as a viable therapeutic strategy, and rational design of inhibitors and vaccines, interfering with this process, is a prime target for antiviral research. To advan
Publikováno v:
Journal of Biomolecular NMR. 19:261-266
In three-dimensional and four-dimensional experiments on doubly labelled proteins not only heteronuclear (13C or 15N) but also proton (1H) frequencies are often indirectly monitored, rather than being directly observed. In this communication we show
Autor:
Gaetano Barbato, Florence Cordier, Benjamin Gerlach, R. De Francesco, Frank Narjes, Sonia Sambucini, V.G. Matassa, Daniel O. Cicero, Renzo Bazzo, Stephan Grzesiek
Publikováno v:
The EMBO Journal. 19:1195-1206
Few structures of viral serine proteases, those encoded by the Sindbis and Semliki Forest viruses, hepatitis C virus (HCV) and cytomegalovirus, have been reported. In the life cycle of HCV a crucial role is played by a chymotrypsin-like serine protea
Autor:
R. Cortese, Gaetano Barbato, Christian Steinkühler, Daniel O. Cicero, R. De Francesco, Renzo Bazzo, Maria Chiara Nardi
Publikováno v:
Journal of Molecular Biology. 289:371-384
The solution structure of the hepatitis C virus (BK strain) NS3 protein N-terminal domain (186 residues) has been solved by NMR spectroscopy. The protein is a serine protease with a chymotrypsin-type fold, and is involved in the maturation of the vir
Autor:
Lucio Miele, Livio Paolillo, Giuditta Mantile, Gaetano Barbato, Anil B. Mukherjee, Teresa Carlomagno, Renzo Bazzo
Publikováno v:
Journal of Biomolecular NMR. 9:35-46
Human uteroglobin (h-UG) or Clara cell 10kDa (cc10kDa) is a steroid-dependent, 17 kDahomodimeric, secretory protein with potent anti-inflammatory/immunomodulatory properties.However, the exact physiological role still remains to be determined. It has
Publikováno v:
Journal of Magnetic Resonance, Series A. 117:267-271
J(XH)]these experiments, particularly for the measurement of long- allows the two satellite components to mutually dephase byrange carbon–proton coupling constants, is becoming quite 907. At this point, a trim pulse can alternatively select eitherc
Publikováno v:
Tetrahedron. 51:10303-10316
A new program for the conformational analysis by NMR of the sugar ring of nucleosides and nucleotides in solution, based on both 1H- 1H and long range 1H- 13C coupling constants is presented. The experimental conditions for the accurate measurement o
Publikováno v:
Biochemistry. 30:575-582
The structure of human calcitonin gene-related peptide 1 (hCGRP-1) has been determined by {sup 1}H NMR in a mixed-solvent system of 50{percent} trifluoroethanol/50{percent} H{sub 2}O at pH 3.7 and 27 {degree}C. Complete resonance assignment was achie