Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Renxu Chang"'
Autor:
Xudong Sun, Shuang Gao, Renxu Chang, Hongdou Jia, Qiushi Xu, John Mauck, Juan J. Loor, Xiaobing Li, Chuang Xu
Publikováno v:
Journal of Dairy Science, Vol 107, Iss 9, Pp 7423-7434 (2024)
ABSTRACT: Excessive concentrations of free fatty acids (FFA) are the main factors causing immune dysfunction and inflammation in dairy cows with ketosis. Polarization of macrophages (the process of macrophages freely switching from one phenotype to a
Externí odkaz:
https://doaj.org/article/943a34819b58415fb872dd2883930420
Autor:
Grant P. Grothusen, Renxu Chang, Zhendong Cao, Nan Zhou, Monika Mittal, Arindam Datta, Phillip Wulfridge, Thomas Beer, Baiyun Wang, Ning Zheng, Hsin-Yao Tang, Kavitha Sarma, Roger A. Greenberg, Junwei Shi, Luca Busino
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The CRL4-DCAF15 E3 ubiquitin ligase complex is targeted by the aryl-sulfonamide molecular glues, leading to neo-substrate recruitment, ubiquitination, and proteasomal degradation. However, the physiological function of DCAF15 remains unknown
Externí odkaz:
https://doaj.org/article/5e99b4c061aa4b64a6e849f6c37a88ab
Autor:
Lei Liu, Baogen Wang, Wei Yang, Qianming Jiang, Juan J. Loor, Lu Ouyang, Huilun Tang, Renxu Chang, Tao Peng, Chuang Xu
Publikováno v:
Journal of Dairy Science, Vol 106, Iss 2, Pp 1315-1329 (2023)
ABSTRACT: Excessive inflammation in bovine mammary endothelial cells (BMEC) due to mastitis leads to disease progression and eventual culling of cattle. Sirtuin 3 (SIRT3), a mitochondrial deacetylase, downregulates pro-inflammatory cytokines in BMEC
Externí odkaz:
https://doaj.org/article/707811a33b3b41768c050d6af371484e
Autor:
Renxu Chang, Xudong Sun, Hongdou Jia, Qiushi Xu, Zhihao Dong, Yan Tang, Shengbin Luo, Qianming Jiang, Juan J. Loor, Chuang Xu
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 13, Iss 1, Pp 1-11 (2022)
Abstract Background In early lactation, bovine mammary epithelial cells undergo serious metabolic challenges and oxidative stress both of which could be alleviated by activation of autophagy. Nuclear factor erythroid 2 related factor 2 (NFE2L2), a ma
Externí odkaz:
https://doaj.org/article/ec6ce05b7f9c4ce7baf5c4b7bcb42981
Autor:
Xudong Sun, Renxu Chang, Yan Tang, Shengbin Luo, Chunhui Jiang, Hongdou Jia, Qiushi Xu, Zhihao Dong, Yusheng Liang, Juan J. Loor, Chuang Xu
Publikováno v:
Journal of Animal Science and Biotechnology, Vol 12, Iss 1, Pp 1-11 (2021)
Abstract Background Bovine mammary epithelial cells after calving undergo serious metabolic challenges and oxidative stress both of which could compromise autophagy. Transcription factor EB (TFEB)-mediated autophagy is an important cytoprotective mec
Externí odkaz:
https://doaj.org/article/a00e000d7d32488f9102716292240081
Autor:
Lele Song, Renxu Chang, Xia Sun, Liying Lu, Han Gao, Huiying Lu, Ritian Lin, Xiaorong Xu, Zhanju Liu, Lixing Zhan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Song, Chang et al. identify miR-494-3p as a protector of colitis in mice. They find that a cytokine–cytokine receptor, miR-494-3p-targeted EDA2R and its ligand EDA-A2 derived from macrophages, suppresses colonic stemness and epithelial repair in co
Externí odkaz:
https://doaj.org/article/e8406da68d1441ed800979ff78505b90
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is associated with high morbidity and mortality. Pogostemon cablin (Blanco) Benth/Huo Xiang (HX) is a perennial herb with unique anti-oxidant and anti-infl
Externí odkaz:
https://doaj.org/article/6256fc54d82242abac7e8f9ae26e1dac
Autor:
Renxu Chang, Lele Song, Yi Xu, Yanjun Wu, Cheng Dai, Xinyu Wang, Xia Sun, Yingyong Hou, Wei Li, Xianbao Zhan, Lixing Zhan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
In breast cancer, the loss of expression of WW domain-containing oxireductase (Wwox) has been observed. Here, the authors illustrate that in triple negative breast cancer models Wwox suppresses metastasis and proliferation via the JAK2/STAT3 pathway.
Externí odkaz:
https://doaj.org/article/46a1268fb89a419cb3100d7ee1428ee9
Autor:
Zhihao DONG, Yuanyuan CHEN, Wei YANG, Ruirui LI, Sansi GAO, Ping HE, Baoyin HUANG, Runqi LIU, Han GUO, Renxu CHANG, Cheng XIA, Chuang XU
Publikováno v:
Kafkas Universitesi Veteriner Fakültesi Dergisi, Vol 24, Iss 1, Pp 61-68 (2017)
Fibroblast Growth Factor 21 (FGF21) is a novel metabolic regulator involved in lipid utilization, and it can involve in the regulation of lipid metabolism. To determine the physiological function of FGF21 in relation to a high-fat diet (HFD) and high
Externí odkaz:
https://doaj.org/article/58d883e40bdf4d9b80c064113d94edbf
Autor:
Yizhe Cui, Renxu Chang, Tao Zhang, Xiaocui Zhou, Qiuju Wang, Haiyun Gao, Lintong Hou, Juan J. Loor, Chuang Xu
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Nonalcoholic fatty liver disease (NAFLD) is a hepatic ailment with a rapidly increasing incidence in the human population due largely to dietary hyper nutrition and subsequent obesity. Discovering effective natural compounds and herbs against NAFLD c
Externí odkaz:
https://doaj.org/article/cd603487279e41ff9744e202d6e0b0dd