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Akademický článek

Impact of an Intervention to Control Imipenem-Resistant Acinetobacter baumannii and Its Resistance Mechanisms: An 8-Year Survey

Autor: Lida Chen, Pinghai Tan, Jianming Zeng, Xuegao Yu, Yimei Cai, Kang Liao, Penghao Guo, Yili Chen, Zongwen Wu, Pinghua Qu, Renxin Cai, Cha Chen, Bin Huang

Publikováno v: Frontiers in Microbiology, Vol 11 (2021)

BackgroundThis study aimed to examine the impact of an intervention carried out in 2011 to combat multi-drug resistance and outbreaks of imipenem-resistant Acinetobacter baumannii (IRAB), and to explore its resistance mechanism.MethodsA total of 2572

Externí odkaz: https://doaj.org/article/1279d618c0ca41578725617ad28d8c34

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Akademický článek

Ceftazidime/avibactam Improves the Antibacterial Efficacy of Polymyxin B Against Polymyxin B Heteroresistant KPC-2-Producing Klebsiella pneumoniae and Hinders Emergence of Resistant Subpopulation in vitro

Autor: Xingyan Ma, Yuting He, Xuegao Yu, Yimei Cai, Jianming Zeng, Renxin Cai, Yang Lu, Liang Chen, Cha Chen, Bin Huang

Publikováno v: Frontiers in Microbiology, Vol 10 (2019)

Due to the increasing multidrug resistance and limited antibiotics, polymyxin B revived as the last resort for the treatment of carbapenemase-producing Klebsiella pneumoniae (CRKP). Unfortunately, the heteroresistance hampers polymyxin B monotherapy

Externí odkaz: https://doaj.org/article/6b1f01802acf49fd99dbc4166010649f

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Sub-inhibitory concentrations of fluoroquinolones increase conjugation frequency

Autor: Hui Yuan, Yang Lu, Jianming Zeng, Shunmei E, Cha Chen, Renxin Cai

Publikováno v: Microbial Pathogenesis. 114:57-62

Bacteria are subjected to sub-minimal inhibitory concentrations (sub-MIC) of antibiotics in various niches where the low-dosage treatment plays a key role in antibiotic resistance selection. However, the mechanism of sub-MIC of antibiotics on the res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13548c745e51c6c9e62c1dd2cfe05e8
https://doi.org/10.1016/j.micpath.2017.11.036

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Promoter Variation and Gene Expression of mcr-1-Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital

Autor: Cha Chen, Yang Lu, Liang Chen, Bin Huang, Yi-Wei Tang, Kai Lan, Weizheng Zhang, Jianming Zeng, Sunmei E, Yuting He, Renxin Cai, Barry N. Kreiswirth, Xingyan Ma

Next-generation sequencing of 6 mcr-1 -harboring Escherichia coli and Klebsiella pneumoniae isolates collected from a tertiary care hospital in China revealed significant sequence variations in the regions flanking the mcr-1 gene. While sequence vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a374853023355c296b88a2711e8c04
https://europepmc.org/articles/PMC5923141/

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Polymyxins Resistance in Enterobacteriaceae ☆

Autor: Cha Chen, Xingyan Ma, Yang Lu, Bin Huang, Yuting He, Jianming Zeng, Renxin Cai

Polymyxins were reintroduced into clinical as a result of the emerging multiple drug-resistant bacteria. As the last resort, resistance of polymyxins had gained global attention. The widely use of polymyxins pushed a rising resistant rate year by yea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97ee48bfba2f056a05e03469c34672c7
https://doi.org/10.1016/b978-0-12-801238-3.64150-8

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Quorum Sensing N-acyl Homoserine Lactones-SdiA Suppresses Escherichia coli-Pseudomonas aeruginosa Conjugation through Inhibiting traI Expression

Autor: Ni Zhang, Bin Huang, Renxin Cai, Lina Wang, Jianming Zeng, Binning Wu, Shunmei E, Xianzhang Huang, Youqiang Li, Cha Chen, Yang Lu

Publikováno v: Frontiers in Cellular and Infection Microbiology

Conjugation is a key mechanism for horizontal gene transfer and plays an important role in bacterial evolution, especially with respect to antibiotic resistance. However, little is known about the role of donor and recipient cells in regulation of co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7948d1a57b155946d06cdc722c03c7ad
https://doi.org/10.3389/fcimb.2017.00007

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Mechanism of azithromycin inhibition of HSL synthesis in Pseudomonas aeruginosa

Autor: Shunmei E, Ni Zhang, Cha Chen, Bin Huang, Renxin Cai, Chengcai Fang, Binning Wu, Jianming Zeng

Publikováno v: Scientific Reports

Pseudomonas aeruginosa is an opportunistic pathogen and a leading cause of nosocomial infections. Unfortunately, P. aeruginosa has low antibiotic susceptibility due to several chromosomally encoded antibiotic resistance genes. Hence, we carried out m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8077981342c582919eac9357d02dc49

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Serum IFN-γ-inducible chemokines CXCL9 and CXCL10 are elevated in non-immediate drug hypersensitivity reactions

Autor: Renxin Cai, Yu-Kun Zhao, Xingqi Zhang, Fang Wang, Dingyang He, Yanting Ye

Publikováno v: Asian Pacific journal of allergy and immunology. 34(3)

Background: The recruitment to the skin of drug-responsive T cells is responsible for inflammatory profiles of nonimmediate drug hypersensitivity reactions (niDHRs). Maculopapular exanthema (MPE) and Stevens-Johnson syndrome (SJS)/toxic epidermal nec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee73bfab04dd22ae39a5bcdaec2d2be
https://pubmed.ncbi.nlm.nih.gov/27001652

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