Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Renwick C J Dobson"'
Autor:
Sean E McGroty, Dhivya T Pattaniyil, Delphine Patin, Didier Blanot, Arvind C Ravichandran, Hironori Suzuki, Renwick C J Dobson, Michael A Savka, André O Hudson
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66458 (2013)
Verrucomicrobium spinosum is a Gram-negative bacterium that is related to bacteria from the genus Chlamydia. The bacterium is pathogenic towards Drosophila melanogaster and Caenorhabditis elegans, using a type III secretion system to facilitate patho
Externí odkaz:
https://doaj.org/article/27bcb25d0ced4676be32cc779260e2c0
Autor:
Michael D W Griffin, Jagan M Billakanti, Akshita Wason, Sabrina Keller, Haydyn D T Mertens, Sarah C Atkinson, Renwick C J Dobson, Matthew A Perugini, Juliet A Gerrard, Frederick Grant Pearce
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40318 (2012)
In plants, the lysine biosynthetic pathway is an attractive target for both the development of herbicides and increasing the nutritional value of crops given that lysine is a limiting amino acid in cereals. Dihydrodipicolinate synthase (DHDPS) and di
Externí odkaz:
https://doaj.org/article/1ea922ff58024eaf9855c830510354cf
Autor:
Sarah C Atkinson, Con Dogovski, Matthew T Downton, F Grant Pearce, Cyril F Reboul, Ashley M Buckle, Juliet A Gerrard, Renwick C J Dobson, John Wagner, Matthew A Perugini
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38318 (2012)
Dihydrodipicolinate synthase (DHDPS) catalyzes the rate limiting step in lysine biosynthesis in bacteria and plants. The structure of DHDPS has been determined from several bacterial species and shown in most cases to form a homotetramer or dimer of
Externí odkaz:
https://doaj.org/article/fd29a4c895724e209e09c54f98419d8e
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20439 (2011)
In some bacterial species and photosynthetic cohorts, including algae, the enzyme L,L-diaminopimelate aminotransferase (DapL) (E.C. 2.6.1.83) is involved in the anabolism of the essential amino acid L-lysine. DapL catalyzes the conversion of tetrahyd
Externí odkaz:
https://doaj.org/article/68890b6dd5554b1b92757f356b73714f
Autor:
James S. Davies, Michael J. Currie, Rachel A. North, Mariafrancesca Scalise, Joshua D. Wright, Jack M. Copping, Daniela M. Remus, Ashutosh Gulati, Dustin R. Morado, Sam A. Jamieson, Michael C. Newton-Vesty, Gayan S. Abeysekera, Subramanian Ramaswamy, Rosmarie Friemann, Soichi Wakatsuki, Jane R. Allison, Cesare Indiveri, David Drew, Peter D. Mace, Renwick C. J. Dobson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Bacteria and archaea use tripartite ATP-independent periplasmic (TRAP) transporters to import essential nutrients. Davies et al. report a high resolution structure of a TRAP and show that it uses an ‘elevator-with-an operator’ mechanism.
Externí odkaz:
https://doaj.org/article/a1b3692949d14006b916bdaba4de7228
Autor:
Tiago Bozzola, Mariafrancesca Scalise, Christer U. Larsson, Michael C. Newton-Vesty, Caterina Rovegno, Ankita Mitra, Jonathan Cramer, Weixiao Yuan Wahlgren, Partha Radhakrishnan Santhakumari, Richard E. Johnsson, Oliver Schwardt, Beat Ernst, Rosmarie Friemann, Renwick C. J. Dobson, Cesare Indiveri, Jenny Schelin, Ulf J. Nilsson, Ulf Ellervik
Publikováno v:
ACS Chemical Biology. 17:1890-1900
Antibiotic resistance is a major worldwide concern, and new drugs with mechanistically novel modes of action are urgently needed. Here, we report the structure-based drug design, synthesis, and evaluation in vitro and in cellular systems of sialic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0951ce620b881eadab452b43a333c6
https://doi.org/10.1021/acschembio.2c00321
https://doi.org/10.1021/acschembio.2c00321
Autor:
Rachel A. North, Weixiao Y. Wahlgren, Daniela M. Remus, Mariafrancesca Scalise, Sarah A. Kessans, Elin Dunevall, Elin Claesson, Tatiana P. Soares da Costa, Matthew A. Perugini, S. Ramaswamy, Jane R. Allison, Cesare Indiveri, Rosmarie Friemann, Renwick C. J. Dobson
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
Mammalian cell surfaces are decorated with complex glycoconjugates that terminate with negatively charged sialic acids. Commensal and pathogenic bacteria can use host-derived sialic acids for a competitive advantage, but require a functional sialic a
Externí odkaz:
https://doaj.org/article/c4502d3e21b5415cac0d17a9a67bb2b1
Publikováno v:
Biochemical Society Transactions
Transcription is the principal control point for bacterial gene expression, and it enables a global cellular response to an intracellular or environmental trigger. Transcriptional regulation is orchestrated by transcription factors, which activate or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58da0edd523027e885796c05492feda7
http://europepmc.org/articles/PMC8786299
http://europepmc.org/articles/PMC8786299
Autor:
Serena A. J. Watkin, Rachel Z. Bennie, Jenna M. Gilkes, Volker M. Nock, F. Grant Pearce, Renwick C. J. Dobson
Publikováno v:
European Biophysics Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cfb696734e24b12d70cea77646a5446
https://doi.org/10.1007/s00249-022-01626-9
https://doi.org/10.1007/s00249-022-01626-9