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The antinociceptive effects and molecular mechanisms of ghrelin(1-7)-NH

Autor: Bing, Wu, Yongling, Liu, Fuyan, Liu, Qing, Deng, Jinglei, Wang, Renwen, Han, Dalei, Zhang, Jiaxiang, Chen, Jie, Wei

Publikováno v: Brain research bulletin. 146

Ghrelin(1-7)-NH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::228c3c438e472d002a263e57deb30357
https://pubmed.ncbi.nlm.nih.gov/30599218

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The anti-cancer agent SU4312 unexpectedly protects against MPP+-induced neurotoxicity via selective and direct inhibition of neuronal NOS

Autor: Wei Cui, Zhi-Xiu Lin, Yifan Han, Shengquan Hu, Zaijun Zhang, Huan Zhang, Fei Sa, Tony Chunglit Choi, Sai Li, Daping Xu, Simon My Lee, Edmond Dik Lung Ma, Zhong Zuo, Renwen Han, Jianhui Rong, Shinghung Mak, Wenming Li, Shuai Yuan

Publikováno v: British Journal of Pharmacology. 168:1201-1214

Background and Purpose SU4312, a potent and selective inhibitor of VEGF receptor-2 (VEGFR-2), has been designed to treat cancer. Recent studies have suggested that SU4312 can also be useful in treating neurodegenerative disorders. In this study, we a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75ee8e354847e3e3137cf04c9f757bc1
https://doi.org/10.1111/bph.12004

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Tacrine(2)–ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway

Autor: Rongbiao Pi, Wei Cui, Shinghung Mak, Yifan Han, Wenming Li, Minzhong Ye, Shengquan Hu, Huan Zhang, Renwen Han

Publikováno v: Neurochemistry International. 59:981-988

Oxidative stress is closely related to the pathogenesis of neurodegenerative disorders such as Parkinson's disease (PD). In this study, we investigated the neuroprotective effect of tacrine-ferulic acid dimers linked by an alkylenediamine side chain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9744ae0ddc72da15aca54422dff01273
https://doi.org/10.1016/j.neuint.2011.09.001

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PI3-K/Akt and ERK pathways activated by VEGF play opposite roles in MPP+-induced neuronal apoptosis

Autor: Renwen Han, Shengquan Hu, Wei Cui, Huan Zhang, Shinghung Mak, Jianhui Rong, Wenming Li, Yifan Han

Publikováno v: Neurochemistry International. 59:945-953

Vascular endothelial growth factor (VEGF), a specific pro-angiogenic peptide, has shown neuroprotective effects in the Parkinson's disease (PD) models, but the underlying mechanisms remain elusive. In this study, the neuroprotective properties of VEG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b10dc3a1b5763ad7c10cd1ad707813
https://doi.org/10.1016/j.neuint.2011.07.005

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Protection against 1-methyl-4-phenylpyridinium ion (MPP+)-induced apoptosis by water extract of ginseng (Panax ginseng C.A. Meyer) in SH-SY5Y cells

Autor: Yifan Han, Shengquan Hu, Renwen Han, Shinghung Mak

Publikováno v: Journal of Ethnopharmacology. 135:34-42

Ethnopharmacological relevance The present study investigates the protective effects of water extract of ginseng ( Panax ginseng C.A. Meyer) against 1-methyl-4-phenylpyridinium ion (MPP + )-induced cytotoxicity in SH-SY5Y human neuroblastoma cells an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98783136fa94ba4e058ed4ad29154bd
https://doi.org/10.1016/j.jep.2011.02.017

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The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS

Autor: Wei, Cui, Zaijun, Zhang, Wenming, Li, Shengquan, Hu, Shinghung, Mak, Huan, Zhang, Renwen, Han, Shuai, Yuan, Sai, Li, Fei, Sa, Daping, Xu, Zhixiu, Lin, Zhong, Zuo, Jianhui, Rong, Edmond Dik-Lung, Ma, Tony Chunglit, Choi, Simon My, Lee, Yifan, Han

Publikováno v: British journal of pharmacology. 168(5)

SU4312, a potent and selective inhibitor of VEGF receptor-2 (VEGFR-2), has been designed to treat cancer. Recent studies have suggested that SU4312 can also be useful in treating neurodegenerative disorders. In this study, we assessed neuroprotection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ea380e84e2631da14f7c70d87a34853
https://pubmed.ncbi.nlm.nih.gov/23062100

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Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets

Autor: Renwen Han, Yifan Han, Jialie Luo, Juan Dou, Hugh H. Chan, Yuming Zhao, Xuejun Zhang, Paul R. Carlier, Huan Zhang, Wenming Li, Wei Cui

Publikováno v: Brain research. 1421

The activation of N-methyl-d-aspartate (NMDA) receptors by excessive release of glutamate is involved in the pathogenesis of ischemic stroke. Thus the NMDA receptor has become an attractive therapeutic target for the development of neuroprotectants,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb0b30c886459a2c00e8a8b221a4693
https://pubmed.ncbi.nlm.nih.gov/21978549

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