Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Renuka Sivapatham"'
Autor:
Atossa Shaltouki, Renuka Sivapatham, Ying Pei, Akos A. Gerencser, Olga Momčilović, Mahendra S. Rao, Xianmin Zeng
Publikováno v:
Stem Cell Reports, Vol 4, Iss 5, Pp 847-859 (2015)
In this study, we used patient-specific and isogenic PARK2-induced pluripotent stem cells (iPSCs) to show that mutations in PARK2 alter neuronal proliferation. The percentage of TH+ neurons was decreased in Parkinson’s disease (PD) patient-derived
Externí odkaz:
https://doaj.org/article/09c9b6a82cb84787af6c448a4944fa27
Autor:
Olga Momcilovic, Renuka Sivapatham, Tal Ronnen Oron, Morten Meyer, Sean Mooney, Mahendra S Rao, Xianmin Zeng
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154890 (2016)
We report generation of induced pluripotent stem cell (iPSC) lines from ten Parkinson's disease (PD) patients carrying SNCA, PARK2, LRRK2, and GBA mutations, and one age-matched control. After validation of pluripotency, long-term genome stability, a
Externí odkaz:
https://doaj.org/article/59a6a0d512ed42f3b9535d2281272a97
Background In recent years, a burgeoning body of evidence has pointed to age-related dysfunction in neuronal autophagy as playing a prominent role in neuropathology associated with Alzheimer’s disease (AD). In the present study, we investigated the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daddb63c63be74b18cdac52fd52b7d4
https://doi.org/10.21203/rs.3.rs-2046848/v1
https://doi.org/10.21203/rs.3.rs-2046848/v1
Autor:
Xueshu, Xie, Manish, Chamoli, Dipa, Bhaumik, Renuka, Sivapatham, Suzanne, Angeli, Julie K, Andersen, Gordon J, Lithgow, Birgit, Schilling
Publikováno v:
J Vis Exp
We and others have shown that the aging process results in a proteome-wide accumulation of insoluble proteins. Knocking down genes encoding the insoluble proteins over 40% of the time results in an extension of the lifespan in C. elegans, suggesting
Autor:
Manish Chamoli, Gordon J. Lithgow, Birgit Schilling, Suzanne Angeli, Dipa Bhaumik, Xueshu Xie, Julie K. Andersen, Renuka Sivapatham
Publikováno v:
Journal of Visualized Experiments.
We and others have shown that the aging process results in a proteome-wide accumulation of insoluble proteins. Knocking down genes encoding the insoluble proteins over 40% of the time results in an extension of the lifespan in C. elegans, suggesting
Autor:
Renuka Sivapatham, Mahendra S. Rao, Akos A. Gerencser, Olga Momčilović, Ying Pei, Atossa Shaltouki, Xianmin Zeng
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 4, Iss 5, Pp 847-859 (2015)
Stem Cell Reports, Vol 4, Iss 5, Pp 847-859 (2015)
Summary In this study, we used patient-specific and isogenic PARK2-induced pluripotent stem cells (iPSCs) to show that mutations in PARK2 alter neuronal proliferation. The percentage of TH+ neurons was decreased in Parkinson’s disease (PD) patient-
Autor:
Xianmin Zeng, Sean D. Mooney, Olga Momčilović, Morten Meyer, Mahendra S. Rao, Tal Ronnen Oron, Renuka Sivapatham
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154890 (2016)
PLoS ONE
Momcilovic, O, Sivapatham, R, Oron, T R, Meyer, M, Mooney, S, Rao, M S & Zeng, X 2016, ' Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations ', P L o S One, vol. 11, no. 5, pp. e0154890 . https://doi.org/10.1371/journal.pone.0154890
PLoS ONE
Momcilovic, O, Sivapatham, R, Oron, T R, Meyer, M, Mooney, S, Rao, M S & Zeng, X 2016, ' Derivation, Characterization, and Neural Differentiation of Integration-Free Induced Pluripotent Stem Cell Lines from Parkinson's Disease Patients Carrying SNCA, LRRK2, PARK2, and GBA Mutations ', P L o S One, vol. 11, no. 5, pp. e0154890 . https://doi.org/10.1371/journal.pone.0154890
We report generation of induced pluripotent stem cell (iPSC) lines from ten Parkinson's disease (PD) patients carrying SNCA, PARK2, LRRK2, and GBA mutations, and one age-matched control. After validation of pluripotency, long-term genome stability, a
Autor:
N J F van den Broek, Judith Campisi, D Putavet, D C van Gent, Boudewijn M.T. Burgering, P L J de Keizer, J.H.J. Hoeijmakers, M P Baar, Arjan B. Brenkman, K.A.T. Naipal, Flore Kruiswijk, Renuka Sivapatham, P.J. van der Spek, Wim H. J. Kruit, Sebastian C. Hasenfuss
Publikováno v:
Oncogene, 35(17), 2166-2177. Nature Publishing Group
Oncogene
Oncogene, 35(17), 2166. Nature Publishing Group
Oncogene
Oncogene, 35(17), 2166. Nature Publishing Group
Melanoma is the most lethal form of skin cancer and successful treatment of metastatic melanoma remains challenging. BRAF/MEK inhibitors only show a temporary benefit due to rapid occurrence of resistance, whereas immunotherapy is mainly effective in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d159499dd1b43e3fd7972e28f4a7040
https://pure.eur.nl/en/publications/65ad3aa2-05f7-42e8-9673-cab4e71557c6
https://pure.eur.nl/en/publications/65ad3aa2-05f7-42e8-9673-cab4e71557c6
Autor:
Renuka Sivapatham, Ying Pei, Mahendra S. Rao, Guadalupe Sierra, Andrzej Swistowski, Xianmin Zeng
Publikováno v:
Scientific Reports
Induced pluripotent stem cells (iPSC) are important tools for drug discovery assays and toxicology screens. In this manuscript, we design high efficiency TALEN and ZFN to target two safe harbor sites on chromosome 13 and 19 in a widely available and
Autor:
Renuka, Sivapatham, Xianmin, Zeng
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1353
One major hurdle to the development of effective treatments to many diseases is the lack of suitable human model systems. The ability to reprogram human somatic cells to induced pluripotent stem cells (iPSC) offers an excellent opportunity to generat