Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Renuka Pillutla"'
Autor:
Yanshan Dai, Uma Kavita, Margit H. Lampen, Sander Gielen, Glen Banks, Paul Levesque, Alexander Kozhich, Renuka Pillutla, Yan Zhang, Vibha Jawa, Leonard Adam
Publikováno v:
Human gene therapy. 33(7-8)
Pre-existing neutralizing antibodies (NAb) to adeno-associated virus (AAV) may diminish the efficacy of AAV-based therapies depending on the titer. To support gene therapy studies in pigs, the seroprevalence of NAb to AAV1, 2, 5, 6, 8, and 9 serotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0305af41d3a11a05e27cc9f4d602127
https://pubmed.ncbi.nlm.nih.gov/34913759
https://pubmed.ncbi.nlm.nih.gov/34913759
Autor:
Brian Booth, Lauren Stevenson, Renuka Pillutla, Michael Buonarati, Chris Beaver, Daniela Fraier, Fabio Garofolo, Sam Haidar, Rafiq Islam, Christopher James, John Kadavil, Olga Kavetska, Fumin Li, Christina Satterwhite, Natasha Savoie, Sriram Subramaniam, Nilufer Tampal, Theingi Thway, Eric Woolf, Olivier Le Blaye, Matthew Andisik, Chad Briscoe, Stephanie Cape, Arindam Dasgupta, Sally Fischer, Roger Hayes, John Kamerud, Gustavo Mendes Lima Santos, Corey Nehls, Catherine Soo, Stephen Vinter, Emma Whale, Keyang Xu, Seongeun (Julia) Cho, Anna Edmison, Sean Kassim, Thais Correa Rocha, Jan Welink, Shashi Amur, Abbas Bandukwala, Elana Cherry, Shirley Hopper, Akiko Ishii-Watabe, Susan Kirshner, Kevin Maher, Joao Pedras-Vasconcelos, Yoshiro Saito, Therese Solstad Saunders, Venke Skibeli, Daniela Verthelyi, Yow-Ming Wang, Haoheng Yan
Publikováno v:
Bioanalysis. 11:2099-2132
The 2019 13th Workshop on Recent Issues in Bioanalysis (WRIB) took place in New Orleans, LA on 1–5 April 2019 with an attendance of over 1000 representatives from pharmaceutical/biopharmaceutical companies, biotechnology companies, contract researc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11defcffa0808309e5eab2a4c0f960bb
https://doi.org/10.4155/bio-2019-0270
https://doi.org/10.4155/bio-2019-0270
Autor:
Wenying Li, Huidong Gu, Naiyu Zheng, Bethanne M Warrack, Robert Neely, Yan J Zhang, Alban Allentoff, Ian M. Catlett, Ming Yao, Mark A. Pattoli, Renuka Pillutla, Kristin Taylor, James R. Burke, Eugene Ciccimaro, Xiling Yuan, Jianing Zeng
Publikováno v:
Analytical Chemistry. 91:8443-8452
We report a novel immunocapture (IC)-LC-MS/MS methodology to directly measure real time in vivo receptor occupancy (RO) for a covalent binding drug in blood lysate. A small molecule quencher was added immediately after sample collection to convert th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d80fb90149eaee16fc0ce20e467e163
https://doi.org/10.1021/acs.analchem.9b01462
https://doi.org/10.1021/acs.analchem.9b01462
Autor:
Li Zhu, Alban Allentoff, Christine Huang, Long Yuan, Kimberly Voronin, Renuka Pillutla, Peggy Liu-Kreyche, Naiyu Zheng, R. Marcus Fancher, Ramaswamy A. Iyer, Qin C Ji
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 165:198-206
Stable isotope labeled (SIL) compounds have been commonly used as internal standards (IS) to ensure the accuracy and quality of liquid chromatography–mass spectrometry (LC–MS) bioanalytical assays. Recently, the application of SIL drugs and LC–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fc68cf12dfa694920138ee93092ab9
https://doi.org/10.1016/j.jpba.2018.12.014
https://doi.org/10.1016/j.jpba.2018.12.014
Autor:
Raja Mangipudy, Ting Su, Linna Wang, Qin C Ji, Kristina D. Chadwick, Bonnie Wang, Renuka Pillutla
Publikováno v:
Bioanalysis. 11:175-184
Aim: The result of investigation on the procedure of sample handling and bioanalysis of small volume of plasma sample for nonclinical studies stored in 0.5-ml micronic tubes was reported. Results/methodology: Sample integrity of the small volume (25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e79fcad10850d3f247bf2327e7dd664
https://doi.org/10.4155/bio-2018-0224
https://doi.org/10.4155/bio-2018-0224
Autor:
Naiyu Zheng, Oscar Puig, Craig Titsch, Zheng Ouyang, Renuka Pillutla, Jianing Zeng, Yang J Zhang, Rasa Santockyte
Publikováno v:
Analytical chemistry. 93(2)
Measurement of monoclonal antibodies (M-proteins) plays an important role in the diagnosis and treatment monitoring of multiple myeloma. Currently available M-protein assays have several limitations, particularly because of their lack of sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7da91230b84e057d1e1fe0bc0a5f3b11
https://pubmed.ncbi.nlm.nih.gov/33300779
https://pubmed.ncbi.nlm.nih.gov/33300779
Autor:
Renuka Pillutla, Jianing Zeng, Olufemi Adelakun, Xi-Tao Wang, Jean McCarty, Huidong Gu, Rasa Santockyte, Kristin Taylor, Naiyu Zheng, Yan J Zhang
Publikováno v:
Analytical chemistry. 92(21)
Despite huge promises, bioanalysis of protein biomarkers in formalin-fixed paraffin-embedded (FFPE) tissues by liquid chromatography-tandem mass spectrometry (LC-MS/MS) for clinical applications is still very challenging. Here, we describe a sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabf9fcfe52a3b76c3ee918f5f29e8b4
https://pubmed.ncbi.nlm.nih.gov/33047598
https://pubmed.ncbi.nlm.nih.gov/33047598
Autor:
LaKenya Williams, Manuela Braun, Douglas Donaldson, Mark G. Qian, Carol Gleason, Tobias Haslberger, Boris Gorovits, Ling He, Jorge Quiroz, Enaksha R Wickremsinhe, David Christopher, Catherine L Brockus, Jens Sydor, Renuka Pillutla
Publikováno v:
Bioanalysis. 12(12)
Historically, ligand-binding assays for pharmacokinetic samples employed duplicate rather than singlet-based analysis. Herein, the Translational and absorption, distribution, metabolism and excretion (ADME) Sciences Leadership Group of the Internatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7211183da8ef65939e4da8e61b76e357
https://pubmed.ncbi.nlm.nih.gov/32558588
https://pubmed.ncbi.nlm.nih.gov/32558588
Autor:
Yan-Shan Dai, Lisa Salvador, Paul Levesque, Uma Kavita, Qin C Ji, Wendy Miller, Yan J Zhang, Renuka Pillutla, Leonard P. Adam
Publikováno v:
Human Gene Therapy Methods. 29:237-250
Recombinant adeno associated viruses (rAAV) have become an important tool for the delivery of gene therapeutics due to long-standing safety and success in clinical trials. Since humans often become exposed to AAVs and develop anti-AAV antibodies (Abs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88775e17f31316680262df4447b2c0e
https://doi.org/10.1089/hgtb.2018.131
https://doi.org/10.1089/hgtb.2018.131
Autor:
Weifeng Xu, Robert Dodge, Michael Sank, Renuka Pillutla, Carol Gleason, Gerry Kolaitis, Binodh DeSilva, Stephen M. Carl, Jennifer Cummings, Marina Juhel
Publikováno v:
Journal of Immunological Methods. 462:34-41
Biological therapeutics are foreign antigens and can potentially induce immune response resulting in the formation of anti-drug antibodies (ADA), which in turn may lead to a wide range of side effects. Neutralizing Ab (NAb) is a subset of ADA that ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac9f2f5b3cb7be2a28b6b03bea47a4d
https://doi.org/10.1016/j.jim.2018.08.003
https://doi.org/10.1016/j.jim.2018.08.003