Výsledky vyhledávání - "Renuka Kandhaya-Pillai"

Key Elements of Cellular Senescence Involve Transcriptional Repression of Mitotic and DNA Repair Genes Through the p53-p16/pRB-E2F-DREAM Complex

Autor: Renuka Kandhaya Pillai, Francesc Miro Mur, Jaume Alijotas-Reig, Tamar Tchkonia, Simo Schwartz, James L. Kirkland, Junko Oshima

Cellular senescence is a dynamic stress response process that contributes to aging. From initiation to maintanence, senescent cells continuously undergo complex molecular changes and develop an altered transcriptome. Understanding how the molecular a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cdc4ffe8949c53733a598fa49bf2895
https://doi.org/10.21203/rs.3.rs-2106211/v1

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SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome—the Myhre syndrome

Autor: Tamara Tchkonia, Fuki M. Hisama, George M. Martin, Xiaomeng Yang, James L. Kirkland, Renuka Kandhaya-Pillai, Takayasu Mori, Deyin Hou, Junko Oshima, Jiaming Zhang, Goli Compoginis

Publikováno v: GeroScience

SMAD4 encodes a member of the SMAD family of proteins involved in the TGF-β signaling pathway. Potentially heritable, autosomal dominant, gain-of-function heterozygous variants of SMAD4 cause a rare developmental disorder, the Myhre syndrome, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cb82df8493429503e39fc5a2d00e0c
https://doi.org/10.1007/s11357-020-00318-6

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Novel LMNA mutations in Greek and Myanmar Patients with Progeroid Features and Cardiac Manifestations

Autor: Renuka Kandhaya-Pillai, Haroula Korovou, George M. Martin, Junko Oshima, Stephanie A. Bucks, Fuki M. Hisama, Soe Yarzar

Publikováno v: Aging pathobiology and therapeutics

Segmental progeroid syndromes are groups of genetic disorders with multiple features resembling accelerated aging. The International Registry of Werner Syndrome (Seattle, WA) recruits pedigrees of progeroid syndromes from all over the world. We ident

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801c9f9fbc1338b95d8e9b42a49de6e3
http://europepmc.org/articles/PMC7500617

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TNF-α/IFN-γ synergy amplifies senescence-associated inflammation and SARS-CoV-2 receptor expression via hyper-activated JAK/STAT1

Autor: Renuka, Kandhaya-Pillai, Xiaomeng, Yang, Tamar, Tchkonia, George M, Martin, James L, Kirkland, Junko, Oshima

Publikováno v: Aging cell. 21(6)

Older age and underlying conditions such as diabetes/obesity or immunosuppression are leading host risk factors for developing severe complications from COVID-19 infection. The pathogenesis of COVID-19-related cytokine storm, tissue damage, and fibro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fb9274f064703ab23e172048a249e4a
https://pubmed.ncbi.nlm.nih.gov/35645319

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TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion

Autor: Tamara Tchkonia, Jaume Alijotas-Reig, Simó Schwartz, James L. Kirkland, Renuka Kandhaya-Pillai, Francesc Miró-Mur

Publikováno v: Aging (Albany NY)

Cellular senescence is a cell fate program that entails essentially irreversible proliferative arrest in response to damage signals. Tumor necrosis factor-alpha (TNFα), an important pro-inflammatory cytokine secreted by some types of senescent cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48aa1ccc6ef14c5af73cd2ca7d70047c
https://doi.org/10.18632/aging.101328

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Bioengineered hyaluronic acid elicited a nonantigenic T cell activation: Implications from cosmetic medicine and surgery to nanomedicine

Autor: Mathilde Hindié, Renuka Kandhaya-Pillai, Jaume Alijotas-Reig, Francesc Miró-Mur

Publikováno v: Journal of Biomedical Materials Research Part A. :180-190

Hyaluronan is known to act as a filling material of extracellular matrices and as an adhesive substrate for cellular migration. Consequently, it is widely used in aesthetic medicine and surgery, and it would be expected to be used in nanomedicine. Pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447e90ce17d8ddee81d00532e45fe373
https://doi.org/10.1002/jbm.a.32794

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