Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Rentian Wu"'
Publikováno v:
Journal of the National Cancer Center, Vol 1, Iss 1, Pp 15-22 (2021)
The long-term effectiveness of targeted cancer therapies is limited by the development of resistance. Although epigenetic reprogramming has been implicated in resistance, the mechanisms remain elusive. Herein, we demonstrate that increased chromatin
Externí odkaz:
https://doaj.org/article/accd85a0450f4044aac0532324b3811d
Autor:
Wootae Kim, Fei Zhao, Rentian Wu, Sisi Qin, Somaira Nowsheen, Jinzhou Huang, Qin Zhou, Yuping Chen, Min Deng, Guijie Guo, Kuntian Luo, Zhenkun Lou, Jian Yuan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The ATR pathway is active during DNA replication stress to maintain genome stability. Here the authors reveal the role of the zinc finger containing protein 161 (ZFP161) to facilitate replication fork stability by acting as a scaffold to facilitate t
Externí odkaz:
https://doaj.org/article/76873473e9a04e0794d2cfae1d18dfb3
Autor:
Aftab Amin, Rentian Wu, Man Hei Cheung, John F. Scott, Ziyi Wang, Zijing Zhou, Changdong Liu, Guang Zhu, Chris Kong-Chu Wong, Zhiling Yu, Chun Liang
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3323-3338.e6 (2020)
Summary: Eukaryotic DNA replication licensing is a prerequisite for, and plays a role in, regulating genome duplication that occurs exactly once per cell cycle. ORC (origin recognition complex) binds to and marks replication origins throughout the ce
Externí odkaz:
https://doaj.org/article/c768563c1c3e4ecdace2f8fdc333fcc6
Autor:
Robert B. Diasio, Steven M. Offer, Tarig A. Elraiyah, Shikshya Shrestha, Garrett S. Dunlap, Calvin R. Jerde, Erin E. Tapper, Qian Nie, Rentian Wu
Legend for Supplementary Figures S1-S6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::225398226812a5b78bc2aaa844f2c18c
https://doi.org/10.1158/0008-5472.22413035
https://doi.org/10.1158/0008-5472.22413035
Autor:
Robert B. Diasio, Steven M. Offer, Tarig A. Elraiyah, Shikshya Shrestha, Garrett S. Dunlap, Calvin R. Jerde, Erin E. Tapper, Qian Nie, Rentian Wu
Real-time PCR primers list.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1857acffd63e519101eb5f69816c2c
https://doi.org/10.1158/0008-5472.22413029
https://doi.org/10.1158/0008-5472.22413029
Autor:
Robert B. Diasio, Steven M. Offer, Tarig A. Elraiyah, Shikshya Shrestha, Garrett S. Dunlap, Calvin R. Jerde, Erin E. Tapper, Qian Nie, Rentian Wu
The antimetabolite 5-fluorouracil (5-FU) is one of the most widely used chemotherapy drugs. Dihydropyrimidine dehydrogenase (DPD) is a major determinant of 5-FU response and toxicity. Although DPYD variants may affect 5-FU metabolism, they do not com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4079b598d1e5755293fa849a9aaca91
https://doi.org/10.1158/0008-5472.c.6508592.v1
https://doi.org/10.1158/0008-5472.c.6508592.v1
Autor:
Robert B. Diasio, Steven M. Offer, Tarig A. Elraiyah, Shikshya Shrestha, Garrett S. Dunlap, Calvin R. Jerde, Erin E. Tapper, Qian Nie, Rentian Wu
Relationship between DPYD and EZH2 expression (S1); Inhibition of Ezh2 results in increased DPYD expression and desensitizes cells to 5-FU (S2); H3K27me3 demethylases UTX and Jmjd3 expression in various tissues (S3); H3K27 trimethylation prevented PU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e96baacb6e85db5e481c6f8f717413
https://doi.org/10.1158/0008-5472.22413032
https://doi.org/10.1158/0008-5472.22413032
Publikováno v:
Journal of the National Cancer Center, Vol 1, Iss 1, Pp 15-22 (2021)
The long-term effectiveness of targeted cancer therapies is limited by the development of resistance. Although epigenetic reprogramming has been implicated in resistance, the mechanisms remain elusive. Herein, we demonstrate that increased chromatin
Autor:
Amin, Aftab, Rentian Wu, Khan, Muhammad Ajmal, Man Hei Cheung, Yanting Liang, Changdong Liu, Guang Zhu, Zhi-Ling Yu, Chun Liang
Publikováno v:
Life Science Alliance; Mar2023, Vol. 6 Issue 3, p1-22, 22p
An essential Noc3p dimerization cycle mediates ORC double-hexamer formation in replication licensing
Autor:
Aftab Amin, Rentian Wu, Muhammad Ajmal Khan, Man Hei Cheung, Yanting Liang, Changdong Liu, Guang Zhu, Zhi-Ling Yu, Chun Liang
Publikováno v:
Life Science Alliance. 6:e202201594
Replication licensing, a prerequisite of DNA replication, helps to ensure once-per-cell-cycle genome duplication. Some DNA replication-initiation proteins are sequentially loaded onto replication origins to form pre-replicative complexes (pre-RCs). O