De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria† †Electronic supplementary information (ESI) available: Synthetic procedures and analytical data for all new compounds. Supporting schemes, figures, and tables. Description of phage-selection and analysis, biochemical and biological assays. See DOI: 10.1039/c7sc03413j

Autor: 't Hart, Peter, Wood, Thomas M., Tehrani, Kamaleddin Haj Mohammad Ebrahim, van Harten, Roel M., Śleszyńska, Małgorzata, Rentero Rebollo, Inmaculada, Hendrickx, Antoni P. A., Willems, Rob J. L., Breukink, Eefjan, Martin, Nathaniel I.

Publikováno v: Chemical Science

Lipid II binding lipopeptides discovered via bicyclic peptide phage display exhibit promising antibacterial activity.
Creative strategies for identifying new antibiotics are essential to addressing the looming threat of a post-antibiotic era. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dfe0caa4d9ea4ab194fdbae14c15674d
http://europepmc.org/articles/PMC5853558

Bicyclic Peptide Ligands Pulled out of Cysteine-Rich Peptide Libraries.

Autor: Shiyu Chen, Rentero Rebollo, Inmaculada, Buth, Sergey A., Morales-Sanfrutos, Julia, Touati, Jeremy, Leiman, Petr G., Heinis, Christian

Publikováno v: Journal of the American Chemical Society; 5/1/2013, Vol. 135 Issue 17, p6562-6569, 8p

Development of Potent and Selective S. aureus Sortase A Inhibitors Based on Peptide Macrocycles.

Autor: Rentero Rebollo I; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , CH-1015 Lausanne, Switzerland., McCallin S; Department of Fundamental Microbiology, University of Lausanne , CH-1015 Lausanne, Switzerland., Bertoldo D; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , CH-1015 Lausanne, Switzerland., Entenza JM; Department of Fundamental Microbiology, University of Lausanne , CH-1015 Lausanne, Switzerland., Moreillon P; Department of Fundamental Microbiology, University of Lausanne , CH-1015 Lausanne, Switzerland., Heinis C; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , CH-1015 Lausanne, Switzerland.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2016 Apr 14; Vol. 7 (6), pp. 606-11. Date of Electronic Publication: 2016 Apr 14 (Print Publication: 2016).

Phage selection of photoswitchable peptide ligands.

Autor: Bellotto S; Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne , CH-1015 Lausanne, Switzerland., Chen S, Rentero Rebollo I, Wegner HA, Heinis C

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2014 Apr 23; Vol. 136 (16), pp. 5880-3. Date of Electronic Publication: 2014 Apr 11.

Boosting the sensitivity of ligand-protein screening by NMR of long-lived states.

Autor: Salvi N; Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland., Buratto R, Bornet A, Ulzega S, Rentero Rebollo I, Angelini A, Heinis C, Bodenhausen G

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2012 Jul 11; Vol. 134 (27), pp. 11076-9. Date of Electronic Publication: 2012 Jun 27.