Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Renta Hutabarat"'
Autor:
Pachamuthu Kandasamy, Shohei Mori, Shigeo Matsuda, Namrata Erande, Dhrubajyoti Datta, Jennifer L. S. Willoughby, Nate Taneja, Jonathan O’Shea, Anna Bisbe, Rajar M. Manoharan, Kristina Yucius, Tuyen Nguyen, Ramesh Indrakanti, Swati Gupta, Jason A. Gilbert, Tim Racie, Amy Chan, Ju Liu, Renta Hutabarat, Jayaprakash K. Nair, Klaus Charisse, Martin A. Maier, Kallanthottathil G. Rajeev, Martin Egli, Muthiah Manoharan
Publikováno v:
Journal of Medicinal Chemistry. 66:2506-2523
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::815ae0fb669898f37b1e2ab925b10193
https://doi.org/10.1021/acs.jmedchem.2c01337
https://doi.org/10.1021/acs.jmedchem.2c01337
Autor:
Kallanthottathil G. Rajeev, Philip Kretschmer, Husain Attarwala, Krishna Aluri, Vasant Jadhav, Ju Liu, Klaus Charisse, Renta Hutabarat, Qianfan Wang, Julie A. Boshar, Ramesh Indrakanti, Muthiah Manoharan, Minggeng Gao, Kevin Fitzgerald, Swati Gupta, Jayaprakash K. Nair, Martin Maier, Jennifer L. S. Willoughby, Xuemei Zhang, Akin Akinc, Christopher R. Brown, Tracy Zimmermann, Sally Schofield, Alfica Sehgal
Publikováno v:
Nucleic Acids Research
Covalent attachment of a synthetic triantennary N-acetylagalactosamine (GalNAc) ligand to chemically modified siRNA has enabled asialoglycoprotein (ASGPR)-mediated targeted delivery of therapeutically active siRNAs to hepatocytes in vivo. This approa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::402f5b83ec7460c63cef2e95df011e1e
https://doi.org/10.1093/nar/gkx818
https://doi.org/10.1093/nar/gkx818
Autor:
Jared Gollob, Verena Karsten, Brian Bettencourt, Malcolm Boyce, Akshay Vaishnaw, Joseph Chiesa, Tracy Zimmermann, Saraswathy V. Nochur, Renta Hutabarat, Amy Chan
Publikováno v:
Molecular Therapy. 25:71-78
Advancement of RNAi-based therapeutics depends on effective delivery to the site of protein synthesis. Although intravenously administered, multi-component delivery vehicles have enabled small interfering RNA (siRNA) delivery and progression into cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842ce51f9dee2f966f951d04fb89269d
https://doi.org/10.1016/j.ymthe.2016.10.019
https://doi.org/10.1016/j.ymthe.2016.10.019
Autor:
Joseph Chiesa, Amy Simon, Jeffrey Cehelsky, Brian Bettencourt, Kevin Fitzgerald, Valerie A. Clausen, Jessica E. Sutherland, Maria Frank-Kamenetsky, Renta Hutabarat, Jay D. Horton, JM Ritter, Timothy Mant, Svetlana Shulga-Morskaya, Verena Karsten, Malathy Munisamy, Abigail Liebow, Akshay Vaishnaw, Jared Gollob, Victor Kotelianski, Saraswathy V. Nochur
Publikováno v:
The Lancet. 383:60-68
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL receptors, leading to their degradation. Genetics studies have shown that loss-of-function mutations in PCSK9 result in reduced plasma LDL cholesterol and decreased risk of coronary h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8c11c6c882cccf5c09317e25602966
https://doi.org/10.1016/s0140-6736(13)61914-5
https://doi.org/10.1016/s0140-6736(13)61914-5
Autor:
Thomas V. Holohan, Christopher J. Horvath, Tia DeFeo-Fraulini, H. Nicholas Marsh, Robert G. Schaub, Sleiman BouFakhreddine, James C. Gilbert, Judith M. Healy, Renta Hutabarat, Patricia G. Merlino
Publikováno v:
Circulation. 116:2678-2686
Background— ARC1779 is a therapeutic aptamer antagonist of the A1 domain of von Willebrand Factor (vWF), the ligand for receptor glycoprotein 1b on platelets. ARC1779 is being developed as a novel antithrombotic agent for use in patients with acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c290da4be7e22fd6f1cdee69273417
https://doi.org/10.1161/circulationaha.107.724864
https://doi.org/10.1161/circulationaha.107.724864
Autor:
K. Olson, N. Brosnan, W.D. Funk, J.R. Preiss, S.D. Lewis, A. Makim, S.R. Deitcher, B. Hussaini, P. Hatala, John L. Diener, J.B. Rottman, J. Wagner-Whyte, L. Cai, J.M. Fraone, T. McCauley, H. Thatte, Renta Hutabarat, P. Treanor, Jeffrey Kurz, R.M. Boomer, C. Horvath, S.F. Khuri
Publikováno v:
Journal of Thrombosis and Haemostasis. 5:P-S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44c245394c0905c9490d81cf982b7f68
https://doi.org/10.1111/j.1538-7836.2007.tb00166.x
https://doi.org/10.1111/j.1538-7836.2007.tb00166.x
Autor:
Tracy Zimmermann, Kallanthottathil G. Rajeev, Qianfan Wang, Michael E. Jung, Jonathan O'Shea, Pachamuthu Kandasamy, Stuart Milstein, Amy Chan, Nate Taneja, Alexander V Kel'in, Ronald J. van der Sluis, Renta Hutabarat, Akin Akinc, Md. Rowshon Alam, Ligang Zhang, Martin Maier, Kevin Fitzgerald, Satya Kuchimanchi, Klaus Charisse, Menno Hoekstra, Theo J.C. Van Berkel, Sarfraz Shaikh, Jennifer L. S. Willoughby, Muthiah Manoharan, Jayaprakash K. Nair
Publikováno v:
Journal of the American Chemical Society, vol 136, iss 49
Nair, JK; Willoughby, JLS; Chan, A; Charisse, K; Alam, MR; Wang, Q; et al.(2014). Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing. Journal of the American Chemical Society, 136(49), 16958-16961. doi: 10.1021/ja505986a. UCLA: Retrieved from: http://www.escholarship.org/uc/item/54c114pc
Nair, JK; Willoughby, JLS; Chan, A; Charisse, K; Alam, MR; Wang, Q; et al.(2014). Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing. Journal of the American Chemical Society, 136(49), 16958-16961. doi: 10.1021/ja505986a. UCLA: Retrieved from: http://www.escholarship.org/uc/item/54c114pc
© 2014 American Chemical Society. Conjugation of small interfering RNA (siRNA) to an asialoglycoprotein receptor ligand derived from N-acetylgalactosamine (GalNAc) facilitates targeted delivery of the siRNA to hepatocytes in vitro and in vivo. The l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6771db5f680b0df7e430efacf19d93
https://escholarship.org/uc/item/54c114pc
https://escholarship.org/uc/item/54c114pc
Autor:
Thomas J. Daly, Frank Lee, James P. Fandl, Xiaobing Xu, Renta Hutabarat, Kevin Bailey, Vivien Wong, Laura Rocco Carpenter, Ellen M. Koehler-Stec, Erica Pyles, Czeslaw Radziejewski, Christopher Hartnett, Jennifer McNay, John S. Rudge, Swayampakula Ramakanth, Scott Carver, George D. Yancopoulos, Tammy T. Huang, Aris N. Economides, Neil Stahl, Michael R. Young
Publikováno v:
Nature Medicine. 9:47-52
Cytokines can initiate and perpetuate human diseases, and are among the best-validated of therapeutic targets. Cytokines can be blocked by the use of soluble receptors; however, the use of this approach for cytokines such as interleukin (IL)-1, IL-4,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89296f15df5ca8c1615ff4f9cc7e38c4
https://doi.org/10.1038/nm811
https://doi.org/10.1038/nm811
Autor:
William Querbes, Satya Kuchimanchi, David Kallend, Kevin Fitzgerald, Kristina Yucius, Renta Hutabarat, Rajeev Kuchimanchi, Andrew Sprague, Jay D. Horton, Klaus Charisse, Stuart Milstein, Abigail Liebow, Martin Maier, Amy Simon, Anna Borodovsky, Jessica E. Sutherland
Publikováno v:
Circulation. 130
Introduction: Cardiovascular disease remains the top cause of mortality in the United States. We have developed, and validated in human trials, a platform for reducing the synthesis of genes expressed in the liver. The platform utilizes a GalNAc suga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad8fa2f423b4da95d425e667c4d72cb8
https://doi.org/10.1161/circ.130.suppl_2.11936
https://doi.org/10.1161/circ.130.suppl_2.11936
Autor:
Amy Simon, Brian C. Cooley, Akin Akinc, Julia Hettinger, Renta Hutabarat, Yongfeng Jiang, Rachel Meyers, June Qin, Mary Carioto, Martin Maier, Klaus Charisse, Harsha K. Prabhala, Husain Attarwala, Rodney M. Camire, Lubo Nechev, Pachamuthu Kandasamy, Lacramioara Ivanciu, Alexander V Kel'in, Muthiah Manoharan, Kallanthottathil G. Rajeev, Scott A Barros, Jayaprakash K. Nair, Don Foster, Satya Kuchimanchi, Yesim Dargaud, Xuemei Zhang, Benny Sørensen, Tim Racie, Stuart Milstein, Alfica Sehgal, Claude Negrier, Josh Brodsky
Publikováno v:
Nature medicine. 21(5)
Hemophilia A and B are inherited bleeding disorders characterized by deficiencies in procoagulant factor VIII (FVIII) or factor IX (FIX), respectively. There remains a substantial unmet medical need in hemophilia, especially in patients with inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4aa616e2a51cb586e3970c1386fe429
https://pubmed.ncbi.nlm.nih.gov/25849132
https://pubmed.ncbi.nlm.nih.gov/25849132