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A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models

Autor: Mattis, Aras, Spangler, B, Fontaine, SD, Shi, Y, Sambucetti, L, Mattis, AN, Hann, B, Wells, JA, Renslo, AR

Publikováno v: Mattis, Aras; Spangler, B; Fontaine, SD; Shi, Y; Sambucetti, L; Mattis, AN; et al.(2016). A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6wr857w4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::d41c545fa818daa80c8c844963a62e1b
http://www.escholarship.org/uc/item/6wr857w4

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A reactivity-based probe of the intracellular labile ferrous iron pool

Autor: Renslo, Adam, Spangler, B, Morgan, CW, Fontaine, SD, Vander, MN, Chang, CJ, Wells, JA, Renslo, AR

Publikováno v: Renslo, Adam; Spangler, B; Morgan, CW; Fontaine, SD; Vander, MN; Chang, CJ; et al.(2016). A reactivity-based probe of the intracellular labile ferrous iron pool. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/6cj9p4h2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::c71ee952ec7cfe953fb57f40a4229791
http://www.escholarship.org/uc/item/6cj9p4h2

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Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery

Autor: Renslo, Adam, Fontaine, SD, DiPasquale, AG, Renslo, AR

Publikováno v: Renslo, Adam; Fontaine, SD; DiPasquale, AG; & Renslo, AR. (2014). Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/42x1h7gc

© 2014 American Chemical Society.Ferrous iron-promoted reduction of a hindered peroxide bond underlies the antimalarial action of the 1,2,4-trioxane artemisinin and the 1,2,4-trioxolane arterolane. In appropriately designed systems, a 1,2,4-trioxola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::6a85a29b552f6b9974a30721fec6b799
http://www.escholarship.org/uc/item/42x1h7gc

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Broad-spectrum allosteric inhibition of herpesvirus proteases

Autor: Craik, Charles, Renslo, Adam, Gable, JE, Lee, GM, Jaishankar, P, Hearn, BR, Waddling, CA, Renslo, AR, Craik, CS

Publikováno v: Craik, Charles; Renslo, Adam; Gable, JE; Lee, GM; Jaishankar, P; Hearn, BR; et al.(2014). Broad-spectrum allosteric inhibition of herpesvirus proteases. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/4s26r3mk

Herpesviruses rely on a homodimeric protease for viral capsid maturation. A small molecule, DD2, previously shown to disrupt dimerization of Kaposis sarcoma-associated herpesvirus protease (KSHV Pr) by trapping an inactive monomeric conformation and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::33ccc1cda335b9083cf37b46fb39b7b5
http://www.escholarship.org/uc/item/4s26r3mk

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Successes and challenges in phenotype-based lead discovery for prion diseases

Autor: Renslo, Adam, Ghaemmaghami, S, Russo, M, Renslo, AR

Publikováno v: Renslo, Adam; Ghaemmaghami, S; Russo, M; & Renslo, AR. (2014). Successes and challenges in phenotype-based lead discovery for prion diseases. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/9mk3c012

Creutzfeldt-Jakob disease (CJD) is a rare but invariably fatal neurodegenerative disease caused by misfolding of an endogenous protein into an alternative pathogenic conformation. The details of protein misfolding and aggregation are not well underst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::bfc2a18d4c9b559c32196b55e15776c5
http://www.escholarship.org/uc/item/9mk3c012

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A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels

Autor: Minor, Daniel, Renslo, Adam, Arkin, Michelle, Bagriantsev, SN, Ang, KH, Gallardo-Godoy, A, Clark, KA, Arkin, MR, Renslo, AR, Minor, DL

Publikováno v: Minor, Daniel; Renslo, Adam; Arkin, Michelle; Bagriantsev, SN; Ang, KH; Gallardo-Godoy, A; et al.(2013). A high-throughput functional screen identifies small molecule regulators of temperature-and mechano-sensitive K2P channels. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/5jc0k9qr

K2P (KCNK) potassium channels generate "leak" potassium currents that strongly influence cellular excitability and contribute to pain, somatosensation, anesthesia, and mood. Despite their physiological importance, K2Ps lack specific pharmacology. Add

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::a00fa9123faa6890241244e04e6df793
http://www.escholarship.org/uc/item/5jc0k9qr

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