Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Renske de Korte-Grimmerink"'
Autor:
Leonie Ratz, Chiara Brambillasca, Leandra Bartke, Maxim A. Huetzen, Jonas Goergens, Orsolya Leidecker, Ron D. Jachimowicz, Marieke van de Ven, Natalie Proost, Bjørn Siteur, Renske de Korte-Grimmerink, Peter Bouwman, Emilia M. Pulver, Roebi de Bruijn, Jörg Isensee, Tim Hucho, Gaurav Pandey, Maarten van Lohuizen, Peter Mallmann, Hans Christian Reinhardt, Jos Jonkers, Julian Puppe
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-19 (2022)
Abstract Background The majority of BRCA1-mutant breast cancers are characterized by a triple-negative phenotype and a basal-like molecular subtype, associated with aggressive clinical behavior. Current treatment options are limited, highlighting the
Externí odkaz:
https://doaj.org/article/9766126bd94646d0abb634dc3e2d1caa
Autor:
Paola Francica, Merve Mutlu, Vincent A. Blomen, Catarina Oliveira, Zuzanna Nowicka, Anika Trenner, Nora M. Gerhards, Peter Bouwman, Elmer Stickel, Maarten L. Hekkelman, Lea Lingg, Ismar Klebic, Marieke van de Ven, Renske de Korte-Grimmerink, Denise Howald, Jos Jonkers, Alessandro A. Sartori, Wojciech Fendler, J. Ross Chapman, Thijn Brummelkamp, Sven Rottenberg
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108068- (2020)
Summary: Using genome-wide radiogenetic profiling, we functionally dissect vulnerabilities of cancer cells to ionizing radiation (IR). We identify ERCC6L2 as a major determinant of IR response, together with classical DNA damage response genes and me
Externí odkaz:
https://doaj.org/article/c1546da443224518b9a9ceeee619ab96
Autor:
Aldo Spanjaard, Ronak Shah, Daniël de Groot, Olimpia Alessandra Buoninfante, Ben Morris, Cor Lieftink, Colin Pritchard, Lisa M Zürcher, Shirley Ormel, Joyce J I Catsman, Renske de Korte-Grimmerink, Bjørn Siteur, Natalie Proost, Terry Boadum, Marieke van de Ven, Ji-Ying Song, Maaike Kreft, Paul C M van den Berk, Roderick L Beijersbergen, Heinz Jacobs
Publikováno v:
Nucleic Acids Research. 50:7420-7435
Crosslink repair depends on the Fanconi anemia pathway and translesion synthesis polymerases that replicate over unhooked crosslinks. Translesion synthesis is regulated via ubiquitination of PCNA, and independently via translesion synthesis polymeras
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d9c57af872ef1699819a71b23deb58
https://doi.org/10.1093/nar/gkac545
https://doi.org/10.1093/nar/gkac545
Autor:
Carmen A, Widmer, Ismar, Klebic, Natalya, Domanitskaya, Morgane, Decollogny, Denise, Howald, Myriam, Siffert, Paul, Essers, Zuzanna, Nowicka, Nadine, Stokar-Regenscheit, Marieke, van de Ven, Renske, de Korte-Grimmerink, José A, Galván, Colin E J, Pritchard, Ivo J, Huijbers, Wojciech, Fendler, Conchita, Vens, Sven, Rottenberg
Publikováno v:
Cancer research communications. 2(10)
In recent years platinum (Pt) drugs have been found to be especially efficient to treat patients with cancers that lack a proper DNA damage response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b3ae48feead58acc9625a899980606f
https://pubmed.ncbi.nlm.nih.gov/36467895
https://pubmed.ncbi.nlm.nih.gov/36467895
Autor:
Sven Rottenberg, Conchita Vens, Wojciech Fendler, Ivo J. Huijbers, Colin E.J. Pritchard, José A. Galván, Renske de Korte-Grimmerink, Marieke van de Ven, Nadine Stokar-Regenscheit, Zuzanna Nowicka, Paul Essers, Myriam Siffert, Denise Howald, Morgane Decollogny, Natalya Domanitskaya, Ismar Klebic, Carmen A. Widmer
In recent years, platinum (Pt) drugs have been found to be especially efficient to treat patients with cancers that lack a proper DNA damage response, for example, due to dysfunctional BRCA1. Despite this knowledge, we are still missing helpful marke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f298b83d5f8eaac3e632f9259a7bf3b
https://doi.org/10.1158/2767-9764.c.6550914.v1
https://doi.org/10.1158/2767-9764.c.6550914.v1
Autor:
Sven Rottenberg, Conchita Vens, Wojciech Fendler, Ivo J. Huijbers, Colin E.J. Pritchard, José A. Galván, Renske de Korte-Grimmerink, Marieke van de Ven, Nadine Stokar-Regenscheit, Zuzanna Nowicka, Paul Essers, Myriam Siffert, Denise Howald, Morgane Decollogny, Natalya Domanitskaya, Ismar Klebic, Carmen A. Widmer
gRNA oligos used for the generation of Lrrc8a or Lrrc8d-knockout cell lines, organoids and tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8fab8ff46482b5da388cda400e92e7
https://doi.org/10.1158/2767-9764.22545336
https://doi.org/10.1158/2767-9764.22545336
Autor:
Sven Rottenberg, Conchita Vens, Wojciech Fendler, Ivo J. Huijbers, Colin E.J. Pritchard, José A. Galván, Renske de Korte-Grimmerink, Marieke van de Ven, Nadine Stokar-Regenscheit, Zuzanna Nowicka, Paul Essers, Myriam Siffert, Denise Howald, Morgane Decollogny, Natalya Domanitskaya, Ismar Klebic, Carmen A. Widmer
TIDE analysis and tumor growth curves of Kaplan Meyer survival graphs shown in main Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a79cb2411409008734ed6096065899b
https://doi.org/10.1158/2767-9764.22545345
https://doi.org/10.1158/2767-9764.22545345
Autor:
Jos Jonkers, Lodewyk F.A. Wessels, Anton Berns, Koen van de Wetering, Sjoerd Klarenbeek, Paul D. Smith, Christopher Phillips, Sunny Mahakena, Renske de Korte-Grimmerink, Anne Paulien Drenth, Ellen Wientjens, Lorenzo Bombardelli, Eva Schut, Koen Schipper, Julian R. de Ruiter, Sjors M. Kas
Overview of the sequenced tumor samples, including sample IDs, treatment information and the type of transplanted material.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063d7df9f07a1fa8d3aa0403c939654b
https://doi.org/10.1158/0008-5472.22419534.v1
https://doi.org/10.1158/0008-5472.22419534.v1
Autor:
Sven Rottenberg, Gerben R. Borst, Jos Jonkers, Marieke van de Ven, Renske de Korte-Grimmerink, Natalie Proost, Ariena Kersbergen, Wendy Sol, Peter Bouwman, Stefano Annunziato, Asli Küçükosmanoğlu, Yike Huang, Alessia Gasparini, Marco Barazas
The defect in homologous recombination (HR) found in BRCA1-associated cancers can be therapeutically exploited by treatment with DNA-damaging agents and PARP inhibitors. We and others previously reported that BRCA1-deficient tumors are initially hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc2d9738c4d07bbf685c25726e6a961
https://doi.org/10.1158/0008-5472.c.6511359
https://doi.org/10.1158/0008-5472.c.6511359
Autor:
Sven Rottenberg, Gerben R. Borst, Jos Jonkers, Marieke van de Ven, Renske de Korte-Grimmerink, Natalie Proost, Ariena Kersbergen, Wendy Sol, Peter Bouwman, Stefano Annunziato, Asli Küçükosmanoğlu, Yike Huang, Alessia Gasparini, Marco Barazas
Supplementary Figure S6. Acquired inactivation of 53BP1 in KB1PM5 tumor-derived cell lines enhances radiosensitivity. Related to Figure 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dffd12f03aa28ac21755dd89d059b9f
https://doi.org/10.1158/0008-5472.22422855.v1
https://doi.org/10.1158/0008-5472.22422855.v1