Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Renske Erion"'
Publikováno v:
eLife, Vol 5 (2016)
Metabolic homeostasis requires coordination between circadian clocks in different tissues. Also, systemic signals appear to be required for some transcriptional rhythms in the mammalian liver and the Drosophila fat body. Here we show that free-runnin
Externí odkaz:
https://doaj.org/article/f23e450441cc48e4824c6984251cf773
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19921 (2011)
A proper balance of lipid breakdown and synthesis is essential for achieving energy homeostasis as alterations in either of these processes can lead to pathological states such as obesity. The regulation of lipid metabolism is quite complex with mult
Externí odkaz:
https://doaj.org/article/8022c84b58ed412b82d17c94191c3f85
Publikováno v:
Genes & development, vol 30, iss 23
Circadian clocks regulate much of behavior and physiology, but the mechanisms by which they do so remain poorly understood. While cyclic gene expression is thought to underlie metabolic rhythms, little is known about cycles in cellular physiology. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bc9a2901e748b63bbf10c6db32e4c1
https://doi.org/10.1101/gad.288258.116
https://doi.org/10.1101/gad.288258.116
Publikováno v:
eLife, Vol 5 (2016)
eLife
eLife
Metabolic homeostasis requires coordination between circadian clocks in different tissues. Also, systemic signals appear to be required for some transcriptional rhythms in the mammalian liver and the Drosophila fat body. Here we show that free-runnin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194d2da4b23ff47febec6d06fe3fc41e
https://doi.org/10.7554/elife.13552
https://doi.org/10.7554/elife.13552
Publikováno v:
Journal of Biological Chemistry. 287:32406-32414
Sleep length and metabolic dysfunction are correlated, but the causal relationship between these processes is unclear. Octopamine promotes wakefulness in the fly by acting through the insulin-producing cells (IPCs) in the fly brain. To determine if i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80485f5ef6fec76f10ef0c86c049c234
https://doi.org/10.1074/jbc.m112.360875
https://doi.org/10.1074/jbc.m112.360875
Autor:
Amita Sehgal, Renske Erion
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 4 (2013)
Frontiers in Physiology, Vol 4 (2013)
The insulin/insulin-like growth factor signaling (IIS) pathway is well established as a critical regulator of growth and metabolic homeostasis across the animal kingdom. Insulin-like peptides (ILPs), the functional analogs of mammalian insulin, were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ced9d7c7175bb1b1d85c1cac480085
https://pubmed.ncbi.nlm.nih.gov/24348428
https://pubmed.ncbi.nlm.nih.gov/24348428
Autor:
Kelly L. Williams, Tadashi Nakaya, Aaron D. Gitler, Jennifer A. Solski, Nancy M. Bonini, Michael P. Hart, Zamia Diaz, Oliver D. King, Robert W. Greene, James Shorter, Julien Couthouis, John Q. Trojanowski, Dana Clay-Falcone, Lauren Elman, Zissimos Mourelatos, Jelena Mojsilovic-Petrovic, Leo McCluskey, Fadia Ibrahim, Garth A. Nicholson, Robert G. Kalb, Hakon Hakonarson, Vivianna M. Van Deerlin, Hyung-Jun Kim, Saarene Panossian, Edward C. Frackelton, Renske Erion, Virginia M.-Y. Lee, Ian P. Blair, Cecilia E. Kim
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting motor neurons. Mutations in related RNA-binding proteins TDP-43, FUS/TLS and TAF15 have been connected to ALS. These three proteins share several features, including t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12308c1b55cc98dc46b51252b1d018dc
https://europepmc.org/articles/PMC3373238/
https://europepmc.org/articles/PMC3373238/
Autor:
Neill R. Graff-Radford, Jelena Mojsilovic-Petrovic, Fadia Ibrahim, Zamia Diaz, Kelly L. Williams, Garth A. Nicholson, Ashley Chiang, John Q. Trojanowski, Lauren Elman, Nancy M. Bonini, Oliver D. King, Dennis W. Dickson, James Epstein, Rosa Rademakers, Hyung-Jun Kim, Robert G. Kalb, Rachel Oristano, Dana Clay-Falcone, Jennifer A. Solski, Tadashi Nakaya, Leo McCluskey, Ian P. Blair, Divya Hosangadi, Caroline Ingre, Michael P. Hart, Albert C. Ludolph, Zissimos Mourelatos, Robert W. Greene, Annie X. Liu, Virginia M.-Y. Lee, Aaron D. Gitler, Daniel M. Ramos, Julien Couthouis, Renske Erion, Kevin B. Boylan, Niti Jethava, Mariely DeJesus-Hernandez, Peter M. Andersen, James Shorter, Wim Robberecht, Vivianna M. Van Deerlin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Amyotrophic lateral sclerosis (ALS) is a devastating and universally fatal neurodegenerative disease. Mutations in two related RNA-binding proteins, TDP-43 and FUS, that harbor prion-like domains, cause some forms of ALS. There are at least 213 human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c131698869d98f8c7094d2b3784d7fb
https://pubmed.ncbi.nlm.nih.gov/36577079
https://pubmed.ncbi.nlm.nih.gov/36577079
Autor:
Renske Erion, James S. Fraser, Sheena C. Degnan, Dorothee Kern, Michael W. Clarkson, Tom Alber
Publikováno v:
Nature, vol 462, iss 7273
Nature
Nature
A long-standing challenge is to understand at the atomic level how protein dynamics contribute to enzyme catalysis. X-ray crystallography can provide snapshots of conformational substates sampled during enzymatic reactions, while NMR relaxation metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29799aaa1ce723c001adccca390c2f7
https://escholarship.org/uc/item/4rq0j99x
https://escholarship.org/uc/item/4rq0j99x