Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Renren Wen"'
Autor:
Yuhong Chen, Mei Yu, Yongwei Zheng, Guoping Fu, Gang Xin, Wen Zhu, Lan Luo, Robert Burns, Quan-Zhen Li, Alexander L. Dent, Nan Zhu, Weiguo Cui, Laurent Malherbe, Renren Wen, Demin Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
B cell response and antibody production are generally facilitated by CD4+ follicular helper (Tfh) cells. Here the authors identify a subset of CXCR5+PD1+CD8+ Tfh cells that is normally suppressed by STAT5 signaling, so that STAT5 deficiency in mice i
Externí odkaz:
https://doaj.org/article/3b58b83ee76b4ab8925812d290639692
Autor:
Mei Yu, Yuhong Chen, Hu Zeng, Yongwei Zheng, Guoping Fu, Wen Zhu, Ulrich Broeckel, Praful Aggarwal, Amy Turner, Geoffrey Neale, Cliff Guy, Nan Zhu, Hongbo Chi, Renren Wen, Demin Wang
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
IL-7R activation drives early B cell development, but the signalling is unclear. Here the authors show PLCγ is involved in IL-7R-induced mTOR activation via a DAG/PKC-dependent pathway, and that double deficiency of the two PLCγ isoforms arrests B
Externí odkaz:
https://doaj.org/article/c452dfc952154a9d82178c4541f18fa3
Autor:
Zhengqi Wang, Tamisha Y. Vaughan, Wandi Zhu, Yuhong Chen, Guoping Fu, Magdalena Medrzycki, Hikaru Nishio, Silvia T. Bunting, Pamela A. Hankey-Giblin, Asma Nusrat, Charles A. Parkos, Demin Wang, Renren Wen, Kevin D. Bunting
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Inflammatory Bowel Disease (IBD) is a multi-factorial chronic inflammation of the gastrointestinal tract prognostically linked to CD8+ T-cells, but little is known about their mechanism of activation during initiation of colitis. Here, Grb2-associate
Externí odkaz:
https://doaj.org/article/2a6344e317274854947962fedcc832e3
Autor:
Gang Xin, David M. Schauder, Begoña Lainez, Jason S. Weinstein, Zhengxi Dai, Yuhong Chen, Enric Esplugues, Renren Wen, Demin Wang, Ian A. Parish, Allan J. Zajac, Joe Craft, Weiguo Cui
Publikováno v:
Cell Reports, Vol 13, Iss 6, Pp 1118-1124 (2015)
Control of chronic viral infections by CD8 T cells is critically dependent on CD4 help. In particular, helper-derived IL-21 plays a key role in sustaining the CD8 T cell response; however, the molecular pathways by which IL-21 sustains CD8 T cell imm
Externí odkaz:
https://doaj.org/article/031268850da540dc86f2ac3d68847235
Autor:
Yongwei Zheng, Tamara Adams, Huiying Zhi, Mei Yu, Renren Wen, Peter J Newman, Demin Wang, Debra K Newman
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119739 (2015)
Receptor-mediated platelet activation requires phospholipase C (PLC) activity to elevate intracellular calcium and induce actin cytoskeleton reorganization. PLCs are classified into structurally distinct β, γ, δ, ε, ζ, and η isoforms. There are
Externí odkaz:
https://doaj.org/article/ee6d8127081545fd81da6f3bbe186adc
Autor:
Adam J. Kanack, Jordan K. Schaefer, Meera Sridharan, Noah P. Splinter, Mindy C. Kohlhagen, Bandana Singh, Silvana B. De Lorenzo, Emily E. Mauch, Maen A. Hussein, Marwan Shaikh, Shaji Kumar, Renren Wen, Demin Wang, David Murray, Anand Padmanabhan
Publikováno v:
Blood. 141:1772-1776
Autor:
Yongwei Zheng, Mei Yu, Yuhong Chen, Liquan Xue, Wen Zhu, Guoping Fu, Stephan W. Morris, Renren Wen, Demin Wang
Publikováno v:
The Journal of Immunology. 210:1222-1235
The caspase recruitment domain family member (CARD)11-Bcl10-Malt1 signalosome controls TGF-β–activated kinase 1 (TAK1) activation and regulates BCR-induced NF-κB activation. In this study, we discovered that CARD19 interacted with TAK1 and inhibi
Autor:
Adam J. Kanack, Antonios Bayas, Gemlyn George, Mouhamed Yazan Abou-Ismail, Bandana Singh, Mindy C. Kohlhagen, Noah P. Splinter, Monika Christ, Markus Naumann, Karen A. Moser, Kristi J. Smock, Alison Grazioli, Renren Wen, Demin Wang, David L. Murray, Anand Padmanabhan
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Background COVID-19 vaccines have been associated with a rare thrombotic and thrombocytopenic reaction, Vaccine-induced immune thrombotic thrombocytopenia (VITT) characterized by platelet-activating anti-PF4 antibodies. This study sought to assess cl
Autor:
Zhi Wen, Remington Finn, Xin Gao, Lin Li, Alexander Hebert, Erik A. Ranheim, Yun Zhou, Grant Yun, Jeroen P. Roose, Joshua J. Coon, Rita Shiang, Renren Wen, Menggang Yu, Demin Wang, Jing Zhang
Publikováno v:
Leukemia. 36:1167-1170
Autor:
Wen, Zhu, Yongwei, Zheng, Mei, Yu, Yaling, Wu, Jianhui, Wei, Lu, Zhou, Guoping, Fu, Nicholas, Schneider, Curtis, Jones, Mehraboon, Irani, Anand, Padmanabhan, Richard H, Aster, Demin, Wang, Renren, Wen
Publikováno v:
Blood.
Heparin-induced thrombocytopenia (HIT) is a serious adverse drug reaction characterized by antibodies that recognize platelet factor 4/heparin complexes (PF4/H) and activate platelets to create a pro-thrombotic state. While a high percentage of hepar