Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Renren, Bai"'
Discovery of dibenzyl amide derivatives as novel CXCR4 modulators against inflammatory bowel disease
Publikováno v:
European Journal of Medicinal Chemistry Reports, Vol 10, Iss , Pp 100134- (2024)
The CXCR4/CXCL12 chemokine axis demonstrates significant potential in the treatment of inflammatory bowel disease (IBD) due to its crucial roles in inflammatory and immune responses. Modulating the CXCR4/CXCL12 pathway can be an effective therapeutic
Externí odkaz:
https://doaj.org/article/50d75d3d886e4d9eb6536b9a8ab59689
Autor:
Yuan Gao, Jilong Duan, Xiawen Dang, Yinghui Yuan, Yu Wang, Xingrui He, Renren Bai, Xiang-Yang Ye, Tian Xie
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
β-Elemene is the major active ingredient of TCM anticancer drug elemene extracts. To further improve its antitumor activity and poor solubility, a polar HDACi pharmacophore was incorporated its scaffold. Systematic SAR studies led to the discovery o
Externí odkaz:
https://doaj.org/article/93747a8a7ef34340a0b60fac772009c2
Autor:
Renren Bai, Junlong Zhu, Ziqiang Bai, Qing Mao, Yingqian Zhang, Zi Hui, Xinyu Luo, Xiang-Yang Ye, Tian Xie
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 379-385 (2022)
Elemene is a second-line broad-spectrum anti-tumour drug that has been used in China for more than two decades. However, its main anti-tumour ingredient, β-elemene, has disadvantages, including excessive lipophilicity and relatively weak anti-tumour
Externí odkaz:
https://doaj.org/article/c8330425afe34b52a41b54be2d86ebaf
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2403-2416 (2022)
A series of novel N-alkyl-N-hydroxyl carboximates derived from β-elemene were fortuitously discovered. Most of them showed more potent anti-proliferative activities than their lead compound β-elemene (1). Notably, compound 11i exhibited significant
Externí odkaz:
https://doaj.org/article/707aa9ee081e4afea07d1d5c814c1b9d
Autor:
Xinqiao Wang, Chuansheng Yao, Yun Zhang, Jiahui Yu, Haoran Qiao, Chengyun Zhang, Yejian Wu, Renren Bai, Hongliang Duan
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-14 (2022)
Abstract Deep learning methods, such as reaction prediction and retrosynthesis analysis, have demonstrated their significance in the chemical field. However, the de novo generation of novel reactions using artificial intelligence technology requires
Externí odkaz:
https://doaj.org/article/9e2a1c9d4f1740c38e2c95c6e9862792
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 2045-2054 (2021)
A novel class of benzamide-hydroxypyridinone (HPO) derivatives were innovatively designed, synthesised, and biologically evaluated as potential multitargeting candidates for the treatment of Alzheimer's disease (AD) through pharmacophores-merged appr
Externí odkaz:
https://doaj.org/article/640824b2d8a2492790e75bd68f7d9f22
Autor:
Hang Zhang, Zheyi Jiang, Chuanbin Shen, Han Zou, Zhiping Zhang, Kaitao Wang, Renren Bai, Yanhua Kang, Xiang-Yang Ye, Tian Xie
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
5-Hydroxymethylfurfural (5-HMF) is a common reaction product during heat processing and the preparation of many types of foods and Traditional Chinese Medicine formulations. The aim of this study was to evaluate the protective effect of 5-HMF on endo
Externí odkaz:
https://doaj.org/article/677f623fc0164569b1050ccd91ae2635
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1080-1099 (2020)
With the development of photodynamic therapy (PDT), remarkable studies have been conducted to generate photosensitisers (PSs), especially porphyrin PSs. A variety of chemical modifications of the porphyrin skeleton have been introduced to improve cel
Externí odkaz:
https://doaj.org/article/694bd2a66198449da1cd596880f47bcb
Akademický článek
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Publikováno v:
Royal Society Open Science, Vol 7, Iss 5 (2020)
Herein, we report the first access of β-elemene derivatives through the SeO2-mediated oxidation reaction. Several new compounds were isolated through such a one-step reaction, and their structures were elucidated using various 2D-NMR techniques. Thi
Externí odkaz:
https://doaj.org/article/220fadb490834420bfcc3faa68170cd8