Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Renquan Ruan"'
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125746 (2015)
In this work, the mechanism of cell bleb formation upon the addition of cryoprotectants (CPAs) was investigated, and the role of cell blebs in protecting cells was determined. The results show that after adding CPAs, the hyperosmotic stress results i
Externí odkaz:
https://doaj.org/article/b3a58ddbe9f04a29a19d481d04679a67
Autor:
Shaohui Cheng, Yuanyuan Zhang, Weiping Ding, Lili Zou, Renquan Ruan, Bensheng Qiu, Pengfei Wei, Fenfen Li
Publikováno v:
Biomaterials. 182:1-12
Vemurafenib is a chemotherapeutic drug recently approved by the FDA to treat melanoma. Because the drug is usually delivered orally, the route of administration readily causes damage to major organs with limited antitumor efficacy and bioavailability
Autor:
Jiqian Zhang, Jun Lin, Chitta Ranjan Patra, Li Zhang, Renquan Ruan, Peipei Jin, Ayan Kumar Barui, Yi Hu, Shan-shan Shi, Wei Zhou, Pengfei Wei, Yunjiao Zhang, Longping Wen, Hou-Rui Zhang
Publikováno v:
Biomaterials. 73:160-174
Accelerating the clearance of intracellular protein aggregates through elevation of autophagy represents a viable approach for the treatment of neurodegenerative diseases. In our earlier report, we have demonstrated the enhanced degradation of mutant
Publikováno v:
Annals of biomedical engineering. 45(6)
Melanoma is a potentially lethal skin cancer with high mortality rate. Recently, the peptide-mediated transdermal delivery of small interference RNA (siRNA) emerges as a promising strategy to treat melanoma by inducing the apoptosis of tumor cells, b
Autor:
Weiping Ding, Dayong Gao, Jing Liu, Renquan Ruan, Pengfei Wei, Sijie Sun, Longping Wen, Ming Chen, Lili Zou
Publikováno v:
Scientific Reports
Topical application of siRNAs through the skin is a potentially effective strategy for the treatment of melanoma tumors. In this study, we designed a new and safe fusion peptide carrier SPACE-EGF to improve the skin and cell penetration function of t
Publikováno v:
Therapeutic delivery. 7(2)
Transdermal delivery of drugs, a compelling route of systemic drug delivery, provides painless, reliable, targeted, efficient and cost effective therapeutic regimen for patients. However, its use is limited by skin barrier especially the stratum corn
Autor:
Renquan Ruan, Wei Zhou, Longping Wen, Jun Lin, Yunjiao Zhang, Weiping Ding, Changli Wang, Li Zhang
Publikováno v:
Molecular pharmaceutics. 12(4)
In this work, we discovered that the Na(+)/K(+)-ATPase beta-subunit (ATP1B1) on epidermal cells plays a key role in the peptide-mediated transdermal delivery of macromolecular drugs. First, using a yeast two-hybrid assay, we screened candidate protei
Publikováno v:
Molecular pharmaceutics. 11(11)
The biologically inspired transdermal enhanced peptide TD1 has been discovered to specifically facilitate transdermal delivery of biological macromolecules. However, the biological behavior of TD1 has not been fully defined. In this study, we find th
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 4, p e0125746 (2015)
PLoS ONE, Vol 10, Iss 4, p e0125746 (2015)
In this work, the mechanism of cell bleb formation upon the addition of cryoprotectants (CPAs) was investigated, and the role of cell blebs in protecting cells was determined. The results show that after adding CPAs, the hyperosmotic stress results i
Publikováno v:
Protein and peptide letters. 21(6)
TD1, a peptide chaperone consisting of the sequence ACSSSPHKHCG, has been shown to facilitate transdermal delivery for protein molecules via either co-administration or the fusion approach. We previously reported that a single TD1 motif, fused to the