Agnostic B cell selection approach identifies antibodies against K. pneumoniae that synergistically drive complement activation

Autor: Sjors P. A. van der Lans, Bart W. Bardoel, Maartje Ruyken, Carla J. C. de Haas, Stan Baijens, Remy M. Muts, Lisette M. Scheepmaker, Piet C. Aerts, Marije F. L. van ’t Wout, Johannes Preiner, Renoud J. Marijnissen, Janine Schuurman, Frank J. Beurskens, Priscilla F. Kerkman, Suzan H. M. Rooijakkers

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Antibody-dependent complement activation plays a key role in the natural human immune response to infections. Currently, the understanding of which antibody-antigen combinations drive a potent complement response on bacteria is limited. Here

Externí odkaz: https://doaj.org/article/a558f4acbc8844f0b4f524c388b29ef9

T-cell stimulating vaccines empower CD3 bispecific antibody therapy in solid tumors

Autor: Jim Middelburg, Marjolein Sluijter, Gaby Schaap, Büşra Göynük, Katy Lloyd, Vitalijs Ovcinnikovs, Gijs G. Zom, Renoud J. Marijnissen, Christianne Groeneveldt, Lisa Griffioen, Gerwin G. W. Sandker, Sandra Heskamp, Sjoerd H. van der Burg, Tsolere Arakelian, Ferry Ossendorp, Ramon Arens, Janine Schuurman, Kristel Kemper, Thorbald van Hall

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)

Abstract CD3 bispecific antibody (CD3 bsAb) therapy is clinically approved for refractory hematological malignancies, but responses in solid tumors have been limited so far. One of the main hurdles in solid tumors is the lack of sufficient T-cell inf

Externí odkaz: https://doaj.org/article/36795cab2cda485e96053669065dc63a

Bacillus Calmette–Guérin-Induced Trained Immunity Is Not Protective for Experimental Influenza A/Anhui/1/2013 (H7N9) Infection in Mice

Autor: L. Charlotte J. de Bree, Renoud J. Marijnissen, Junda M. Kel, Sietske K. Rosendahl Huber, Peter Aaby, Christine Stabell Benn, Marcel V. W. Wijnands, Dimitri A. Diavatopoulos, Reinout van Crevel, Leo A. B. Joosten, Mihai G. Netea, John Dulos

Publikováno v: J. de Bree, L C, Marijnissen, R J, Kel, J M, Huber, S K R, Aaby, P, Benn, C S, Wijnands, M V W, Diavatopoulos, D A, Crevel, R V, Joosten, L A B, Netea, M G & Dulos, J 2018, ' Bacillus Calmette-Guérin-Induced trained immunity is not protective for experimental influenza A/Anhui/1/2013 (H7N9) infection in mice ', Frontiers in Immunology, vol. 9, no. APR, 869 . https://doi.org/10.3389/fimmu.2018.00869
Frontiers in Immunology
Frontiers in Immunology, 9
Frontiers in Immunology, Vol 9 (2018)

Avian influenza A of the subtype H7N9 has been responsible for almost 1,600 confirmed human infections and more than 600 deaths since its first outbreak in 2013. Although sustained human-to-human transmission has not been reported yet, further adapta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6732cc381957e006d0ec2c6bb4d9a3c2
https://doi.org/10.3389/fimmu.2018.00869

Interleukin-21 Receptor Deficiency Increases the Initial Toll-like Receptor 2 Response but Protects Against Joint Pathology by Reducing Th1 and Th17 Cells During Streptococcal Cell Wall Arthritis

Autor: Wim B. van den Berg, Cheryl Nickerson-Nutter, Fons A. J. van de Loo, Renoud J. Marijnissen, Deborah Young, Sabrina Garcia de Aquino, Annemieke M. H. Boots, Debbie M. Roeleveld, Shahla Abdollahi-Roodsaz, Annemiek B. van Spriel, Marije I. Koenders

Publikováno v: Arthritis & Rheumatology. 66:886-895

OBJECTIVE: The cytokine interleukin-21 (IL-21) can have both proinflammatory and immunosuppressive effects. The purpose of this study was to investigate the potential dual role of IL-21 in experimental arthritis in relation to Th17 cells. METHODS: An

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6c34a2dee1ffb43c53e84d803aab10c
https://doi.org/10.1002/art.38312

Anti IL-17A therapy inhibits bone loss in TNF-α-mediated murine arthritis by modulation of the T-cell balance

Autor: Wim B. van den Berg, Mario M. Zaiss, Jochen Zwerina, Karin Zwerina, Renoud J. Marijnissen, Iain Mclnnes, Georg Schett, Leo A. B. Joosten, Axel J. Hueber, Marije I. Koenders, Gisela Ruiz Heiland, Wolfgang Baum

Publikováno v: European Journal of Immunology. 42:413-423

Tumour necrosis factor alpha (TNF-α) is a major inducer for inflammation and bone loss. Here, we investigated whether interleukin (IL)-17 plays a role in TNF-α-mediated inflammation and bone resorption. Human TNF-α transgenic (hTNFtg) mice were tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fa4668761e0bdfbb4266fbd3cad7ed4
https://doi.org/10.1002/eji.201141871