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CREEPING FAT-DERIVED FREE FATTY ACIDS INDUCE HYPERPLASIA OF INTESTINAL MUSCULARIS PROPRIA MUSCLE CELLS - A NOVEL LINK BETWEEN FAT AND INTESTINAL STRICTURE FORMATION IN CROHN'S DISEASE.

Autor: Liu W; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Mao R; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Nga Le TH; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., West G; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Varadharajan V; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Banerjee R; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Doyon G; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Mukherjee P; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Nguyen QT; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Mulya A; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Rennison JH; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Gordon IO; Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic Foundation, Cleveland, USA., Cruise M; Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic Foundation, Cleveland, USA., Hu S; Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic Foundation, Cleveland, USA., Czarnecki D; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Plesec T; Department of Pathology, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic Foundation, Cleveland, USA., Chandra J; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Banerjee S; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Wang J; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Xinxiang Key Laboratory of Inflammation and Immunology, Xinxiang Medical University, Xinxiang, China., Massey WJ; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Goren I; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Lin SN; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Kurada S; Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, USA., Cohen BL; Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute; Cleveland Clinic Foundation, Cleveland, USA., Qazi T; Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute; Cleveland Clinic Foundation, Cleveland, USA., Holubar SD; Department of Colorectal Surgery, Digestive Diseases Institute; Cleveland Clinic Foundation, Cleveland, USA., Lipman J; Department of Colorectal Surgery, Digestive Diseases Institute; Cleveland Clinic Foundation, Cleveland, USA., Kanters A; Department of Colorectal Surgery, Digestive Diseases Institute; Cleveland Clinic Foundation, Cleveland, USA., Gliniak CM; Touchstone Diabetes Center, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA., Scherer PE; Touchstone Diabetes Center, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA., Chen MH; Department of Gastroenterology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China., Siegmund B; Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Gastroenterology, Infectious Diseases and Rheumatology, 12203 Berlin, Germany., Ivanov AI; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA., Fiocchi C; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute; Cleveland Clinic Foundation, Cleveland, USA., Van Wagoner DR; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Brown JM; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Rieder F; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA; Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases Institute; Cleveland Clinic Foundation, Cleveland, USA; Cleveland Clinic Program for Global Translational Inflammatory Bowel Diseases (GRID). Electronic address: riederf@ccf.org.

Publikováno v: Gastroenterology [Gastroenterology] 2024 Nov 08. Date of Electronic Publication: 2024 Nov 08.

Novel functional atrial fibrillation risk genes and pathways identified from coexpression analyses in human left atria.

Autor: Wass SY; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio., Offerman EJ; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio., Sun H; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio., Hsu J; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio., Rennison JH; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio., Cantlay CC; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio., McHale ML; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio., Gillinov AM; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio; Department of Cardiothoracic Surgery, Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, Ohio., Moravec C; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio., Smith JD; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio; Department of Cardiovascular Medicine, Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, Ohio., Van Wagoner DR; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio., Barnard J; Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio., Chung MK; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio; Department of Cardiovascular Medicine, Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, Ohio. Electronic address: chungm@ccf.org.

Publikováno v: Heart rhythm [Heart Rhythm] 2023 Sep; Vol. 20 (9), pp. 1219-1226. Date of Electronic Publication: 2023 Jun 16.

Transcriptomics-based network medicine approach identifies metformin as a repurposable drug for atrial fibrillation.

Autor: Lal JC; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., NE5-305, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA., Mao C; Division of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA., Zhou Y; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., NE5-305, Cleveland, OH 44195, USA., Gore-Panter SR; Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Biological, Geological, and Environmental Sciences, Cleveland State University, Cleveland, OH 44115, USA., Rennison JH; Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Lovano BS; Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Castel L; Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Shin J; Division of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA., Gillinov AM; Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH 44195, USA., Smith JD; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA; Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Barnard J; Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA., Van Wagoner DR; Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Luo Y; Division of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: yuan.luo@northwestern.edu., Cheng F; Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave., NE5-305, Cleveland, OH 44195, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: chengf@ccf.org., Chung MK; Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA; Cardiovascular Medicine, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, 9500 Euclid Ave., J2-2, OH 44195, USA. Electronic address: chungm@ccf.org.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2022 Oct 18; Vol. 3 (10), pp. 100749. Date of Electronic Publication: 2022 Oct 11.

Genetic-Genomic Insights Into the Metabolic Determinants of Spontaneous Atrial Fibrillation.

Autor: Gore-Panter SR; From the Department of Molecular Cardiology, Cleveland Clinic, OH., Rennison JH; From the Department of Molecular Cardiology, Cleveland Clinic, OH., Van Wagoner DR; From the Department of Molecular Cardiology, Cleveland Clinic, OH. vanwagd@ccf.org.

Publikováno v: Circulation. Arrhythmia and electrophysiology [Circ Arrhythm Electrophysiol] 2017 Aug; Vol. 10 (8).