SARS-CoV-2 spike-based virus-like particles incorporate influenza H1/N1 antigens and induce dual immunity in mice.

Autor: Sanchez-Martinez ZV; Human Health Therapeutics Research Centre, National Research Council of Canada, Montreal, QC H4P 2R2, Canada.; Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada., Alpuche-Lazcano SP; Human Health Therapeutics Research Centre, National Research Council of Canada, Montreal, QC H4P 2R2, Canada.; Current address: Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), A.P. 510-3, Cuernavaca Morelos (CP 62250), Mexico., Stuible M; Human Health Therapeutics Research Centre, National Research Council of Canada, Montreal, QC H4P 2R2, Canada., Akache B; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON K1A 0R6, Canada., Renner TM; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON K1A 0R6, Canada., Deschatelets L; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON K1A 0R6, Canada., Dudani R; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON K1A 0R6, Canada., Harrison BA; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON K1A 0R6, Canada., McCluskie MJ; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON K1A 0R6, Canada., Hrapovic S; Aquatic and Crop Resources Development Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC H4P 2R2, Canada., Blouin J; Human Health Therapeutics Research Centre, National Research Council of Canada, Montreal, QC H4P 2R2, Canada., Wang X; Quantum and Nanotechnologies Research Centre, National Research Council Canada, 11421 Saskatchewan Drive, Edmonton, AB T6G 2M9, Canada., Schuller M; Quantum and Nanotechnologies Research Centre, National Research Council Canada, 11421 Saskatchewan Drive, Edmonton, AB T6G 2M9, Canada., Cui K; Quantum and Nanotechnologies Research Centre, National Research Council Canada, 11421 Saskatchewan Drive, Edmonton, AB T6G 2M9, Canada., Cho JY; Quantum and Nanotechnologies Research Centre, National Research Council Canada, 11421 Saskatchewan Drive, Edmonton, AB T6G 2M9, Canada., Durocher Y; Human Health Therapeutics Research Centre, National Research Council of Canada, Montreal, QC H4P 2R2, Canada.; Department of Biochemistry and Molecular Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada.. Electronic address: yves.durocher@nrc.gc.ca.

Publikováno v: Vaccine [Vaccine] 2024 Oct 30; Vol. 42 (26), pp. 126463. Date of Electronic Publication: 2024 Oct 30.

Preclinical evaluation of manufacturable SARS-CoV-2 spike virus-like particles produced in Chinese Hamster Ovary cells.

Autor: Alpuche-Lazcano SP; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada., Stuible M; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada., Akache B; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Tran A; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Kelly J; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Dr, Ottawa, ON, K1A 0R6, Canada., Hrapovic S; Aquatic and Crop Resources Development Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada., Robotham A; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Dr, Ottawa, ON, K1A 0R6, Canada., Haqqani A; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Dr, Ottawa, ON, K1A 0R6, Canada., Star A; Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Dr, Ottawa, ON, K1A 0R6, Canada., Renner TM; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Blouin J; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada., Maltais JS; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada., Cass B; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada., Cui K; Nanotechnology Research Centre, National Research Council Canada, 11421 Saskatchewan Drive, Edmonton, AB, T6G 2M9, Canada., Cho JY; Nanotechnology Research Centre, National Research Council Canada, 11421 Saskatchewan Drive, Edmonton, AB, T6G 2M9, Canada., Wang X; Nanotechnology Research Centre, National Research Council Canada, 11421 Saskatchewan Drive, Edmonton, AB, T6G 2M9, Canada., Zoubchenok D; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada., Dudani R; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Duque D; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., McCluskie MJ; Human Health Therapeutics Research Centre, National Research Council Canada, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Durocher Y; Human Health Therapeutics Research Centre, National Research Council Canada, 6100 Royalmount Avenue, Montreal, QC, H4P 2R2, Canada. yves.durocher@cnrc-nrc.gc.ca.

Publikováno v: Communications medicine [Commun Med (Lond)] 2023 Aug 23; Vol. 3 (1), pp. 116. Date of Electronic Publication: 2023 Aug 23.

Antiretroviral APOBEC3 cytidine deaminases alter HIV-1 provirus integration site profiles.

Autor: Ajoge HO; Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, London, ON, Canada., Renner TM; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Bélanger K; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Greig M; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Dankar S; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada., Kohio HP; Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, London, ON, Canada., Coleman MD; Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, London, ON, Canada., Ndashimye E; Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, London, ON, Canada., Arts EJ; Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, London, ON, Canada., Langlois MA; Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. langlois@uottawa.ca.; Ottawa Center for Infection, Immunity and Inflammation (CI3), Ottawa, ON, Canada. langlois@uottawa.ca., Barr SD; Western University, Schulich School of Medicine and Dentistry, Department of Microbiology and Immunology, London, ON, Canada. stephen.barr@uwo.ca.

Publikováno v: Nature communications [Nat Commun] 2023 Jan 10; Vol. 14 (1), pp. 16. Date of Electronic Publication: 2023 Jan 10.

Characterization of Systemic and Mucosal Humoral Immune Responses to an Adjuvanted Intranasal SARS-CoV-2 Protein Subunit Vaccine Candidate in Mice.

Autor: Maltseva M; Department of Biochemistry, Microbiology & Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Galipeau Y; Department of Biochemistry, Microbiology & Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada., Renner TM; National Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada., Deschatelets L; National Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada., Durocher Y; National Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada., Akache B; National Research Council Canada, Human Health Therapeutics, Ottawa, ON K1A 0R6, Canada., Langlois MA; Department of Biochemistry, Microbiology & Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.; Ottawa Center for Infection, Immunity and Inflammation (CI3), Ottawa, ON K1H 8N5, Canada.

Publikováno v: Vaccines [Vaccines (Basel)] 2022 Dec 23; Vol. 11 (1). Date of Electronic Publication: 2022 Dec 23.

Intranasal immunization with a proteosome-adjuvanted SARS-CoV-2 spike protein-based vaccine is immunogenic and efficacious in mice and hamsters.

Autor: Stark FC; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Akache B; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada. Bassel.akache@nrc-cnrc.gc.ca., Deschatelets L; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Tran A; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Stuible M; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Durocher Y; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., McCluskie MJ; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Agbayani G; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Dudani R; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Harrison BA; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Renner TM; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Makinen SR; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Bavananthasivam J; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Duque D; National Research Council Canada, Human Health Therapeutics, 1200 Montreal Road, Ottawa, ON, K1A 0R6, Canada., Gagne M; Biodextris Inc., 525 boul. Cartier West, Laval, QC, H7V 3S8, Canada., Zimmermann J; Inspirevax Inc., 46 rue de Saint-Tropez, Kirkland, QC, H9J 2K6, Canada., Zarley CD; Oragenics, Inc., 13700 Progress Blvd, Alachua, FL, 32608, USA.; CDZarley LLC., 133 Butternut Dr, Pottstown, PA, 19464, USA., Cochrane TR; Oragenics, Inc., 13700 Progress Blvd, Alachua, FL, 32608, USA.; BrevisRefero Corporation, 295 Alliance Road Suite 1B/C, Milton, ON, L9T 2X7, Canada., Handfield M; Oragenics, Inc., 13700 Progress Blvd, Alachua, FL, 32608, USA.

Publikováno v: Scientific reports [Sci Rep] 2022 Jun 13; Vol. 12 (1), pp. 9772. Date of Electronic Publication: 2022 Jun 13.