The Improved Antineoplastic Activity of Thermophilic L-Asparaginase Tli10209 via Site-Directed Mutagenesis

Autor: Lijuan Zhang, Simeng Ding, Xiuhui Tang, Renjun Gao, Rui Huo, Guiqiu Xie

Publikováno v: Biomolecules, Vol 14, Iss 6, p 686 (2024)

Amino acid deprivation therapy (AADT) is a novel anticancer therapy, considered nontoxic and selective. Thermophilic L-asparaginase enzymes display high stability and activity at elevated temperatures. However, they are of limited use in clinical app

Externí odkaz: https://doaj.org/article/a38ef83e68ab4884996a561c9395fc7e

Site-Specific, Covalent Immobilization of Dehalogenase ST2570 Catalyzed by Formylglycine-Generating Enzymes and Its Application in Batch and Semi-Continuous Flow Reactors

Autor: Hui Jian, Yingwu Wang, Yan Bai, Rong Li, Renjun Gao

Publikováno v: Molecules, Vol 21, Iss 7, p 895 (2016)

Formylglycine-generating enzymes can selectively recognize and oxidize cysteine residues within the sulfatase sub motif at the terminus of proteins to form aldehyde-bearing formylglycine (FGly) residues, and are normally used in protein labeling. In

Externí odkaz: https://doaj.org/article/682d7dee37a64fe7bd71138305f85ef5

Superanionic Solvent-Free Liquid Enzymes Exhibit Enhanced Structures and Activities

Autor: Ye Zhou, Jannik Nedergaard Pedersen, Jacob Nedergaard Pedersen, Nykola C. Jones, Søren Vrønning Hoffmann, Steen Vang Petersen, Jan Skov Pedersen, Adam Perriman, Renjun Gao, Zheng Guo

Publikováno v: Zhou, Y, Pedersen, J N, Pedersen, J N, Jones, N C, Hoffmann, S V, Petersen, S V, Pedersen, J S, Perriman, A, Gao, R & Guo, Z 2022, ' Superanionic Solvent-Free Liquid Enzymes Exhibit Enhanced Structures and Activities ', Advanced Science, vol. 9, no. 32, 2202359 . https://doi.org/10.1002/advs.202202359

The surface of a carboxylate-enriched octuple mutant of Bacillus subtilis lipase A (8M) is chemically anionized to produce core (8M)-shell (cationic polymer surfactants) bionanoconjugates in protein liquid form, which are termed anion-type biofluids.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a21cdc64bf58ad03ffe3dbb056e732
https://pure.au.dk/portal/da/publications/superanionic-solventfree-liquid-enzymes-exhibit-enhanced-structures-and-activities(8db27454-53aa-41a2-b258-401116d4de19).html

Mild Hypothermia Therapy Lowers the Inflammatory Level and Apoptosis Rate of Myocardial Cells of Rats with Myocardial Ischemia-Reperfusion Injury via the NLRP3 Inflammasome Pathway

Autor: Yitong Li, Xinrui Zhang, Yanli Wang, Yu Cai, Renjun Gao, Xianyan Wang, Hongye Zhao, Hao Zong, Bo Tang

Publikováno v: Computational and Mathematical Methods in Medicine
Computational and Mathematical Methods in Medicine, Vol 2021 (2021)

Objective. To explore the protective effects and mechanism of mild hypothermia treatment in the treatment of myocardial ischemia-reperfusion injury. Material and Methods. A total of 20 Sprague-Dawley (SD) rats were assigned to 4 groups: the blank con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a85c9cacf25d14c3fae4437d4d29752b
https://doi.org/10.1155/2021/6415275

Galactosyldiacylglycerols: From a Photosynthesis-Associated Apparatus to Structure-Defined In Vitro Assembling

Autor: Jiabao Lyu, Renjun Gao, Zheng Guo

Publikováno v: Lyu, J, Gao, R & Guo, Z 2021, ' Galactosyldiacylglycerols : From a Photosynthesis-Associated Apparatus to Structure-Defined In Vitro Assembling ', Journal of Agricultural and Food Chemistry, vol. 69, no. 32, pp. 8910–8928 . https://doi.org/10.1021/acs.jafc.1c00204

Being ubiquitously present in plants, microalgae, and cyanobacteria and as the major constituents of thylakoid membranes, monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG) make up approximately 52 and 26%, respectively, of chl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155afd9640486c007f3a5325d45b6eca
https://doi.org/10.1021/acs.jafc.1c00204