Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Renjian Xiao"'
Publikováno v:
Nucleic Acids Research
Cas12f, also known as Cas14, is an exceptionally small type V-F CRISPR–Cas nuclease that is roughly half the size of comparable nucleases of this type. To reveal the mechanisms underlying substrate recognition and cleavage, we determined the cryo-E
Publikováno v:
Nat Chem Biol
Cas12g, the type V–G CRISPR–Cas effector, is an RNA-guided ribonuclease that targets single-stranded RNA substrate. The CRISPR–Cas12g system offers a potential platform for transcriptome engineering and diagnostic applications. We determined th
Dissertation/ Thesis
Autor:
Renjian Xiao (8992832)
The CRISPR-Cas systems, originally evolved as bacterial and archaeal adaptive immune systems against viral infections, have been ingeniously repurposed for genome editing. The ongoing evolutionary competition between bacteria and phages has given ris
Autor:
Shukun Wang, Zhuang Li, Ruijie Han, Indranil Mukherjee, Clinton Gabel, Leifu Chang, Renjian Xiao
Publikováno v:
Mol Cell
The type V-K CRISPR-Cas system, featured by Cas12k effector with a naturally inactivated RuvC domain and associated with Tn7-like transposon for RNA-guided DNA transposition, is a promising tool for precise DNA insertion. To reveal the mechanism unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6e1dd0b67550ac2699169884ca1132
https://doi.org/10.1101/2021.07.07.451486
https://doi.org/10.1101/2021.07.07.451486
Publikováno v:
Cell Res
Cas12f, also known as Cas14, is an exceptionally small type V-F CRISPR-Cas nuclease that is roughly half the size of comparable nucleases of this type. To reveal the mechanisms underlying substrate recognition and cleavage, we determined the cryo-EM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97923819c59d2909236853adb2bda0bd
https://doi.org/10.1101/2020.12.22.424058
https://doi.org/10.1101/2020.12.22.424058
Publikováno v:
Nat Struct Mol Biol
Cas12i is a recently identified type V CRISPR-Cas endonuclease that predominantly cleaves the non-target strand of a double-stranded DNA substrate. This nicking activity of Cas12i could potentially be used for genome editing with high specificity. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5609321575526d37b3a44b01214957ae
https://europepmc.org/articles/PMC8256696/
https://europepmc.org/articles/PMC8256696/