Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Renger G. Tiessen"'
Autor:
Renger G. Tiessen, Ciara A. Kennedy, Bradley T. Keller, Nancy Levin, Lisette Acevedo, Bronislava Gedulin, Andre A. van Vliet, Alejandro Dorenbaum, Melissa Palmer
Publikováno v:
BMC Gastroenterology, Vol 18, Iss 1, Pp 1-17 (2018)
Abstract Background Pathogenesis in non-alcoholic steatohepatitis (NASH) involves abnormal cholesterol metabolism and hepatic accumulation of toxic free cholesterol. Apical sodium-dependent bile acid transporter (ASBT) inhibition in the terminal ileu
Externí odkaz:
https://doaj.org/article/3d128a07b8274c4e9e7f28c5bb378c0b
Autor:
Gerhard Arold, Joanne B.L. Tan, Manmohan Reddy Leleti, Jenna L. Jeffrey, Devika Ashok, Renger G. Tiessen, Aimee Rieger, Lisa Seitz, Matthew J. Walters, Jay P. Powers, Joyson Joseph Karakunnel, Lixia Jin
Publikováno v:
Investigational new drugs. 37(4)
Adenosine suppresses antitumor immune responses via A2a and A2b receptors expressed on intratumoral immune cells. This effect is mediated by increased cyclic adenosine 5′-monophosphate (AMP) levels and phosphorylation of cyclic AMP response element
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac27a0011b98f6e166801e63c4ccdae
https://pubmed.ncbi.nlm.nih.gov/30569245
https://pubmed.ncbi.nlm.nih.gov/30569245
Autor:
Cornelius F. Waller, Catherine E. Micales, Gopinath Ranganna, Renger G. Tiessen, Mark Liu, Andrew D. Shaw, Rajiv Sharma, Mark Baczkowski, Eduardo J. Pennella, Mudgal Kothekar, Abhijit Barve, Tracey E. Lawrence
Publikováno v:
Journal of cancer research and clinical oncology. 144(6)
Pegfilgrastim is a long-acting granulocyte colony-stimulating factor indicated for prevention of febrile neutropenia in patients receiving myelosuppressive chemotherapy by promoting neutrophil recovery. This phase 1, randomized, double-blind, three-w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c790622b95619f01125f34843a35f6
https://pubmed.ncbi.nlm.nih.gov/29671069
https://pubmed.ncbi.nlm.nih.gov/29671069
Autor:
Andre van Vliet, Bradley T. Keller, Melissa Palmer, Alejandro Dorenbaum, Ciara Kennedy, Renger G. Tiessen, Lisette Acevedo, Bronislava Gedulin, Nancy Levin
Publikováno v:
BMC Gastroenterology
BMC Gastroenterology, Vol 18, Iss 1, Pp 1-17 (2018)
BMC Gastroenterology, Vol 18, Iss 1, Pp 1-17 (2018)
Background Pathogenesis in non-alcoholic steatohepatitis (NASH) involves abnormal cholesterol metabolism and hepatic accumulation of toxic free cholesterol. Apical sodium-dependent bile acid transporter (ASBT) inhibition in the terminal ileum may fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bccbc1bd1d43bb9965c0709ba31ffdf0
https://pubmed.ncbi.nlm.nih.gov/29304731
https://pubmed.ncbi.nlm.nih.gov/29304731
Autor:
Jay C. Strum, Rajesh K. Malik, Patrick J. Roberts, Ewoud Jan Van Hoogdalem, Henko Tadema, Hannah Storrie-White, Renger G. Tiessen, William A. Wargin, John E. Bisi, Shenghui He, Karenann M. Makhuli, Jessica A. Sorrentino, Norman E. Sharpless
Publikováno v:
Science Translational Medicine. 9
Conventional cytotoxic chemotherapy is highly effective in certain cancers, but causes dose-limiting damage to normal proliferating cells, especially hematopoietic stem and progenitor cells (HSPCs). Serial exposure to cytotoxics causes a long-term he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5e89799557bc758029edc7a9d9a4f3f
https://doi.org/10.1126/scitranslmed.aal3986
https://doi.org/10.1126/scitranslmed.aal3986
Autor:
André M. M. Miltenburg, Marita Prohn, Renger G. Tiessen, Jacqueline H. M. van Kuijk, Martin de Kort, Rob J. W. Berg
Publikováno v:
British Journal of Clinical Pharmacology. 75:1221-1230
Aim Conjugation to antithrombin III ATIII-binding pentasaccharides has been proposed as a novel method to extend the half-life of therapeutic proteins. We aim to validate this technological concept in man by performing a first-in-human study using Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::703d7d259ebd386b1f009a31a8f4a9c6
https://doi.org/10.1111/j.1365-2125.2012.04460.x
https://doi.org/10.1111/j.1365-2125.2012.04460.x
Autor:
Bo Yang, Teddy Kosoglou, Robert R. Fales, Robert Keller, David L. Cutler, Larisa Reyderman, Renger G. Tiessen, Andre van Vliet
Publikováno v:
European Journal of Clinical Pharmacology. 68:249-258
The aim of our study was to evaluate the pharmacology of vorapaxar (SCH 530348), an oral PAR-1 antagonist, in healthy volunteers.In two randomized, placebo-controlled studies, subjects received either single ascending doses of vorapaxar (0.25, 1, 5,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011414384346f95534b550fb55aa1fec
https://doi.org/10.1007/s00228-011-1120-6
https://doi.org/10.1007/s00228-011-1120-6
Autor:
Yali Zhu, Tanya Boutros, Stephen E. Maxwell, Renger G. Tiessen, Teddy Kosoglou, Paul Statkevich, David L. Cutler, Ramachandran Suresh, Bo Yang
Publikováno v:
Current Medical Research and Opinion. 20:1185-1195
Ezetimibe is a lipid-lowering drug indicated for the treatment of hypercholesterolemia as co-administration with HMG-CoA reductase inhibitors (statins) or as monotherapy. The primary objectives of this study were to evaluate the pharmacodynamic effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8fa527b019ca766ade3ee497316627
https://doi.org/10.1185/030079904125004213
https://doi.org/10.1185/030079904125004213
Publikováno v:
Clinica chimica acta, 316(1-2), 1-10. ELSEVIER SCIENCE BV
Background: Tight regulation of blood glucose levels from patients suffering from diabetes mellitus can significantly reduce the complications associated with this disease. For this reason, elaborate research efforts have been devoted to the developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a9a981ef4716c092c90f9ff08a23e71
https://doi.org/10.1016/s0009-8981(01)00574-5
https://doi.org/10.1016/s0009-8981(01)00574-5
Publikováno v:
Analytica Chimica Acta. 379:327-335
Background: An ultrafiltration (UF) technique was developed for continuous subcutaneous (s.c.) sampling and on-line analysis of absolute glucose and lactate concentrations in tissue. The relation between subcutaneous and blood concentrations was stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb1f0b845c6aa6991ca3c8a1e4efcd9e
https://doi.org/10.1016/s0003-2670(98)00601-1
https://doi.org/10.1016/s0003-2670(98)00601-1