Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer

Autor: Renee Vermeij, Toos Daemen, Geertruida H. de Bock, Pauline de Graeff, Ninke Leffers, Annechien Lambeck, Klaske A. ten Hoor, Harry Hollema, Ate G. J. van der Zee, Hans W. Nijman

Publikováno v: Clinical and Developmental Immunology, Vol 2010 (2010)

The prognosis of epithelial ovarian cancer (EOC), the primary cause of death from gynaecological malignancies, has only modestly improved over the last decades. Immunotherapeutic treatment using a cocktail of antigens has been proposed as a “univer

Externí odkaz: https://doaj.org/article/3a3d1eab845a458bb2b9a343d0185062

Supplementary Materials from Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response

Autor: Sjoerd H. van der Burg, Cornelis J.M. Melief, Hans W. Nijman, Theo Stijnen, Gemma G. Kenter, Tjalling Bosse, Gertjan J. Fleuren, J. Hanneke N.G. Oude Elberink, Jaap Oostendorp, A. Rob P.M. Valentijn, Harry Hollema, Toos Daemen, Lorraine M. Fathers, J. Baptist M.Z. Trimbos, Marjolein J. Kagie, Henk W. Schreuder, Marc van Beurden, Bart W.J. Hellebrekers, Edith M.G. van Esch, Ineke L.E. Hamming, Margriet J.G. Löwik, Dorien M.A. Berends-van der Meer, Nikki M. Loof, Linda F.M. Stynenbosch, Renee Vermeij, Marij J.P. Welters, Mariëtte I.E. van Poelgeest

supplementary material and methods Table S1. Reasons for exclusion of patients from outcome analysis Table S2. Summary statistics of patient groups according to linear mixed model analysis Table S3. All related systemic adverse events by study group

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b8a6677f65bf9841f179d57ec0aef3
https://doi.org/10.1158/1078-0432.22459244.v1

Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response

Autor: J Hanneke N G Oude Elberink, Marij J. P. Welters, Marjolein J. Kagie, Nikki M. Loof, Theo Stijnen, Linda F. M. Stynenbosch, Bart W. J. Hellebrekers, Marc van Beurden, Margriet J. G. Löwik, A. Rob P. M. Valentijn, Ineke E. Hamming, Sjoerd H. van der Burg, Tjalling Bosse, Henk W.R. Schreuder, Dorien M A Berends-van der Meer, Hans W. Nijman, Mariëtte I.E. van Poelgeest, Edith M G van Esch, Renee Vermeij, Gert Jan Fleuren, Toos Daemen, J. Baptist Trimbos, Cornelis J. M. Melief, Harry Hollema, Lorraine M. Fathers, Gemma G. Kenter, Jaap Oostendorp

Publikováno v: Clinical cancer research, 22(10), 2342-2350. American Association for Cancer Research Inc.
Clinical Cancer Research, 22(10), 2342-2350. AMER ASSOC CANCER RESEARCH
van Poelgeest, M I E, Welters, M J P, Vermeij, R, Stynenbosch, L F M, Loof, N M, Berends-van der Meer, D M A, Lowik, M J G, Hamming, I L E, van Esch, E M G, Hellebrekers, B W J, van Beurden, M, Schreuder, H W, Kagie, M J, Trimbos, J B M Z, Fathers, L M, Daemen, T, Hollema, H, Valentijn, A R P M, Oostendorp, J, Oude Elberink, H N G, Fleuren, G J, Bosse, T, Kenter, G G, Stijnen, T, Nijman, H W, Melief, C J M & van der Burg, S H 2016, ' Vaccination against Oncoproteins of HPV16 for Noninvasive Vulvar/Vaginal Lesions: Lesion Clearance Is Related to the Strength of the T-Cell Response ', Clinical Cancer Research, vol. 22, no. 10, pp. 2342-2350 . https://doi.org/10.1158/1078-0432.CCR-15-2594
Clinical Cancer Research, 22(10), 2342. American Association for Cancer Research Inc.
Clinical Cancer Research, 22(10), 2342-2350. American Association for Cancer Research Inc.

Purpose: Therapeutic vaccination with human papillomavirus type 16 (HPV16) E6 and E7 synthetic long peptides (SLP) is effective against HPV16-induced high-grade vulvar and vaginal intraepithelial neoplasia (VIN/VaIN). However, clinical nonresponders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0019df04b3e776a79539df40f209528
https://doi.org/10.1158/1078-0432.ccr-15-2594

Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer: A single-arm phase II study

Autor: Anna K.L. Reyners, Ninke Leffers, Harry Hollema, Ineke E. Hamming, Baukje Nynke Hoogeboom, Toos Daemen, Hans W. Nijman, Joost Bart, Cornelis J. M. Melief, Renee Vermeij, Jan W. Drijfhout, Jaap Oostendorp, Sjoerd H. van der Burg, Ate G.J. van der Zee, Rinze Wolf, Barbara H. W. Molmans

Publikováno v: International Journal of Cancer, 131(5), E670-E680. Wiley
University of Groningen
International Journal of Gynecological Cancer, 21(12). LIPPINCOTT WILLIAMS & WILKINS

Introduction: In view of the poor prognosis of ovarian cancer, new treatment modalities such as immunotherapy are under investigation. We have shown that a p53-SLP vaccine induces p53-specific T-cell responses. Yet, no clinical responses were observe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7d779b205ad37e2b4cf95a52d2dc5d8
https://research.rug.nl/en/publications/76494b48-9215-4657-9f01-f53e2fd9cbb5

Long-term clinical and immunological effects of p53-SLP (R) vaccine in patients with ovarian cancer

Autor: Toos Daemen, Hans W. Nijman, Ninke Leffers, Rinze Wolf, Kees J. M. Melief, Ute Schulze, Ineke E. Hamming, Sjoerd H. van der Burg, Baukje Nynke Hoogeboom, Ate G. van der Zee, Renee Vermeij

Publikováno v: International Journal of Cancer, 130(1), 105-112. Wiley

Vaccine-induced p53-specific immune responses were previously reported to be associated with improved response to secondary chemotherapy in patients with small cell lung cancer. We investigated long-term clinical and immunological effects of the p53-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855bf00b1cf4256fb7609f7b81872c45
http://hdl.handle.net/1887/106285