Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Renee Spencer"'
Autor:
Kristen Renee Spencer, Howard S. Hochster, Patrick M Boland, Lyudmyla Derby Berim, Timothy Kennedy, Miral Grandhi, Russell C Langan, Dirk F. Moore, Michael P. Kane, Smitha S. Krishnamurthi, Skye C. Mayo, Anup Kasi, Agustin Pimentel, Darren R. Carpizo
Publikováno v:
Journal of Clinical Oncology. 41:103-103
103 Background: Novel strategies to improve the efficacy of immune checkpoint inhibitors in microsatellite stable (MSS) mCRC are needed. CV301 is a vector-based vaccine that expresses carcinoembryonic antigen (CEA) and mucin 1 (MUC1), and in a phase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::616769a248a3a408df18a396542973ee
https://doi.org/10.1200/jco.2023.41.4_suppl.103
https://doi.org/10.1200/jco.2023.41.4_suppl.103
Autor:
Howard S. Hochster, Hao Liu, Lyudmyla Derby Berim, Kristen Renee Spencer, Pat Gulhati, Manda DiRubbo, Seth D. Cohen, Patrick Lee, Stuart P. Leitner, Delia Radovich, Christian Misdary, Christian Perez, Sutirtha Datta, Andrea Gonzalez, Tracie Saunders, Patrick M Boland
Publikováno v:
Journal of Clinical Oncology. 41:144-144
144 Background: TAS-102 (trifluridine/tipiracil) is a novel oral antimetabolite for late line metastatic colorectal cancer (CRC) approved in 2018. Many patients are treated early in their course with oxaliplatin (OX), particularly adjuvant, and may b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb95db16639d726f0274f8fccc089c3d
https://doi.org/10.1200/jco.2023.41.4_suppl.144
https://doi.org/10.1200/jco.2023.41.4_suppl.144
Publikováno v:
Journal of the Society for Social Work and Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91312602ef6576a9e465ca104857f11f
https://doi.org/10.1086/718516
https://doi.org/10.1086/718516
Autor:
Richard D. Kim, Mustapha Tehfe, Petr Kavan, Jorge Chaves, Jeremy S. Kortmansky, Eric Xueyu Chen, Christopher Hanyoung Lieu, Lucas Wong, Marwan Fakih, Kristen Renee Spencer, Qing Zhao, Raluca Predoiu, Chenxiang Li, David Carpenter, Pierre Leconte, E. Gabriela Chiorean
Publikováno v:
Journal of Clinical Oncology. 40:3521-3521
3521 Background: Response to antiPD-1 monotherapy is poor in patients (pts) with advanced microsatellite stable (MSS)/mismatch-repair proficient (pMMR) CRC. Combination of chemotherapy with antiPD-1 pembro may potentiate the antitumor immune response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36d1a082f388ac0ffd704b5fb492cfae
https://doi.org/10.1200/jco.2022.40.16_suppl.3521
https://doi.org/10.1200/jco.2022.40.16_suppl.3521
Autor:
Eric Xueyu Chen, Petr Kavan, Mustapha Tehfe, Jeremy S. Kortmansky, Michael B. Sawyer, E. Gabriela Chiorean, Christopher Hanyoung Lieu, Blase N. Polite, Lucas Wong, Marwan Fakih, Kristen Renee Spencer, Jorge Chaves, Chenxiang Li, David Carpenter, Pierre Leconte, Richard D. Kim
Publikováno v:
Journal of Clinical Oncology. 40:3573-3573
3573 Background: Response to antiPD-1 monotherapy is poor in microsatellite stable (MSS)/mismatch-repair proficient (pMMR) mCRC; the combination of antiPD-1 pembro + anti-MEK bini, with or without chemo, may improve upon this limited response. KEYNOT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b230cf4041a2c24c454e0e7f53cf8e5
https://doi.org/10.1200/jco.2022.40.16_suppl.3573
https://doi.org/10.1200/jco.2022.40.16_suppl.3573
Autor:
Patrick Fleming, Chunxia Chen, Dirk F. Moore, Howard S. Hochster, Salma K. Jabbour, Lyudmyla Derby Berim, Kristen Renee Spencer, Pat Gulhati, Kristen Donohue, Nell Maloney Patel, Patrick M Boland
Publikováno v:
Journal of Clinical Oncology. 40:e15587-e15587
e15587 Background: For resected stage II MSI-high (MSI-H) colorectal cancer (CRC) without high-risk features (HRF), standard of care recommendation per NCCN guidelines is observation. For tumors with HRF, the prognostic significance and impact of adj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b842d44f6f4cb0ebc63bf3fce692f125
https://doi.org/10.1200/jco.2022.40.16_suppl.e15587
https://doi.org/10.1200/jco.2022.40.16_suppl.e15587
Autor:
Jessica Caro, Christina Boatwright, Xiaochun Li, Constance Fiocco, Jessica M Stempel, James Hart Stoeckle, James W. Smithy, Allison Betof Warner, Elaine Shum, Joshua K. Sabari, Jyoti Malhotra, Nancy Chan, Kristen Renee Spencer, Pamela L. Kunz, Judith D. Goldberg, Janice M. Mehnert
Publikováno v:
Journal of Clinical Oncology. 40:11002-11002
11002 Background: Gender disparity is an important issue in medicine, as women occupy a minority of academic leadership positions despite increased representation in the physician workforce. One important aspect is the gender gap of speakers at acade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c46841f36c9dbf6803bb281c38605be
https://doi.org/10.1200/jco.2022.40.16_suppl.11002
https://doi.org/10.1200/jco.2022.40.16_suppl.11002
Autor:
Kristen Renee Spencer, Anita Ahmed Turk, Shikha Jain, Kelsey Klute, Sam Joseph Lubner, Dirk F. Moore, Howard S. Hochster
Publikováno v:
Journal of Clinical Oncology. 40:TPS493-TPS493
TPS493 Background: Both the incidence and death rate of hepatocellular carcinoma (HCC) are on the rise in the United States, and overall, the prognosis is grim. First-line treatment options for patients with advanced disease previously included tyros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e9aceb063278713a2398d24b91b0f00
https://doi.org/10.1200/jco.2022.40.4_suppl.tps493
https://doi.org/10.1200/jco.2022.40.4_suppl.tps493
Autor:
Vincent Leveque, Gloria Ao-Ieong, Sophie Le Pogam, Bamberg Joe Timothy, Javier de Vicente, Stengel Peter J, Stacey Renee Spencer, John P. Fischer, Todd R. Elworthy, Andrew J. Briggs, Jim Li, Peter Mohr, Michael Brandl, Sunil Sukhtankar, Ramona Hilgenkamp, Calvin Yee, Ludmila Alexandrova, Robinson John E, Fell Jay Bradford, Beihan Wang, April Wong, Robert Than Hendricks, Farrell Robert P, Isabel Najera, David Bernard Smith, Seth F. Harris, Sonal Rajyaguru, Susan Larrabee, James F. Blake, George Adjabeng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5652-5656
A series of benzo[d]isothiazole-1,1-dioxides were designed and evaluated as inhibitors of HCV polymerase NS5B. Structure-based design led to the incorporation of a high affinity methyl sulfonamide group. Structure-activity relationship (SAR) studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270693e52369b485d5d38536330a0ea0
https://doi.org/10.1016/j.bmcl.2009.08.022
https://doi.org/10.1016/j.bmcl.2009.08.022
Autor:
Elbert Chin, Manjiri Ghate, Vincent Leveque, Sonal Rajyaguru, Bill Fitch, Jahari Laurant Tracy, Michael Brandl, Steve A. de Keczer, Ramona Hilgenkamp, Fell Jay Bradford, Tatyana Voronin, Isabel Najera, Gloria Ao-Ieong, Javier de Vicente, Shao-Yong Wu, Beihan Wang, Stacey Renee Spencer, Stengel Peter J, Peter Mohr, Mohammad R. Masjedizadeh, James F. Blake, Robert Than Hendricks, Todd R. Elworthy, David Bernard Smith, Junping Zhao, Ludmila Alexandrova, Robinson John E, Al Lui, John P. Fischer, Seth F. Harris, Jim Li, Connie Oshiro, Calvin Yee, Sophie Le Pogam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5648-5651
Benzothiazine-substituted tetramic acids were discovered as highly potent non-nucleoside inhibitors of HCV NS5B polymerase. X-ray crystallography studies confirmed the binding mode of these inhibitors with HCV NS5B polymerase. Rational optimization o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7482cb6bce12ac0c2b982d6fc4cff88a
https://doi.org/10.1016/j.bmcl.2009.08.023
https://doi.org/10.1016/j.bmcl.2009.08.023