Výsledky vyhledávání

Akademický článek

Using shRNA experiments to validate gene regulatory networks

Autor: Catharina Olsen, Kathleen Fleming, Niall Prendergast, Renee Rubio, Frank Emmert-Streib, Gianluca Bontempi, John Quackenbush, Benjamin Haibe-Kains

Publikováno v: Genomics Data, Vol 4, Iss C, Pp 123-126 (2015)

Quantitative validation of gene regulatory networks (GRNs) inferred from observational expression data is a difficult task usually involving time intensive and costly laboratory experiments. We were able to show that gene knock-down experiments can b

Externí odkaz: https://doaj.org/article/8967cfc2aaf746ea84dcd33facda8890

Zobrazit plný text záznamu

Akademický článek

High Throughput Sequencing of Extracellular RNA from Human Plasma.

Autor: Kirsty M Danielson, Renee Rubio, Fieda Abderazzaq, Saumya Das, Yaoyu E Wang

Publikováno v: PLoS ONE, Vol 12, Iss 1, p e0164644 (2017)

The presence and relative stability of extracellular RNAs (exRNAs) in biofluids has led to an emerging recognition of their promise as 'liquid biopsies' for diseases. Most prior studies on discovery of exRNAs as disease-specific biomarkers have focus

Externí odkaz: https://doaj.org/article/890281031cf24bd08f011e7ec4c1e3e2

Zobrazit plný text záznamu

Akademický článek

Viral perturbations of host networks reflect disease etiology.

Publikováno v: PLoS Computational Biology, Vol 8, Iss 6, p e1002531 (2012)

Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations. Here we examine w

Externí odkaz: https://doaj.org/article/799864a4ab4c4db9b486151cf21f32a5

Zobrazit plný text záznamu

Akademický článek

Angiogenic mRNA and microRNA gene expression signature predicts a novel subtype of serous ovarian cancer.

Autor: Stefan Bentink, Benjamin Haibe-Kains, Thomas Risch, Jian-Bing Fan, Michelle S Hirsch, Kristina Holton, Renee Rubio, Craig April, Jing Chen, Eliza Wickham-Garcia, Joyce Liu, Aedin Culhane, Ronny Drapkin, John Quackenbush, Ursula A Matulonis

Publikováno v: PLoS ONE, Vol 7, Iss 2, p e30269 (2012)

Ovarian cancer is the fifth leading cause of cancer death for women in the U.S. and the seventh most fatal worldwide. Although ovarian cancer is notable for its initial sensitivity to platinum-based therapies, the vast majority of patients eventually

Externí odkaz: https://doaj.org/article/882777890708423181fff7a4cf12a1ab

Zobrazit plný text záznamu

Akademický článek

Therapeutic implications of GIPC1 silencing in cancer.

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e15581 (2010)

GIPC1 is a cytoplasmic scaffold protein that interacts with numerous receptor signaling complexes, and emerging evidence suggests that it plays a role in tumorigenesis. GIPC1 is highly expressed in a number of human malignancies, including breast, ov

Externí odkaz: https://doaj.org/article/6d1b85371e1d4a2e868189e325035379

Zobrazit plný text záznamu

Akademický článek

Whole-genome gene expression profiling of formalin-fixed, paraffin-embedded tissue samples.

Autor: Craig April, Brandy Klotzle, Thomas Royce, Eliza Wickham-Garcia, Tanya Boyaniwsky, John Izzo, Donald Cox, Wendell Jones, Renee Rubio, Kristina Holton, Ursula Matulonis, John Quackenbush, Jian-Bing Fan

Publikováno v: PLoS ONE, Vol 4, Iss 12, p e8162 (2009)

We have developed a gene expression assay (Whole-Genome DASL), capable of generating whole-genome gene expression profiles from degraded samples such as formalin-fixed, paraffin-embedded (FFPE) specimens.We demonstrated a similar level of sensitivity

Externí odkaz: https://doaj.org/article/0735bd5dd3434e959c37db5983211d2e

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání