Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Renee R. Hukkanen"'
Autor:
Charles Mattis, Natalie Bratcher, Monika Burns, Christopher Carosino, Christina de Zafra, R. Marcus Fancher, Katrin Georgi, Candace Graff, Renee R. Hukkanen, Colena Johnson, Yanbin Lao, Amber Lange, Donna Lee, Michelle Lepherd, Sean Maguire, Mantas Malisauskas, Melinda Manuel, Sonia Miranda, Lori Reed, Rosemary Santos, Brian Sayers, David Shaw, David Shuster
Publikováno v:
International Journal of Toxicology. 41:291-296
The IQ Consortium NHP Reuse Working Group (WG) comprises members from 15 pharmaceutical and biotechnology companies. In 2020, the WG developed and distributed a detailed questionnaire on protein non-naïve NHP reuse to the WG member companies. The WG
Publikováno v:
Toxicologic Pathology. :019262332211469
The advancement of an investigational new drug in humans is a significant developmental milestone. In first-in-human (FIH)-enabling toxicology studies, the highest dose without a test article–related adverse effect (no-observed-adverse-effect-level
Opinion on Performing Pathology Peer-Review During the Global Pandemic: Challenges and Opportunities
Publikováno v:
Toxicologic Pathology. 48:944-948
The coronavirus disease 2019 pandemic has affected business on numerous fronts in unprecedented and abrupt ways. From site closures and local “stay-at-home orders” to travel advisories and restrictions, the day-to-day practice of toxicologic path
Publikováno v:
Toxicologic pathology. 47(7)
Pathologists are trained medical professionals with special expertise in diagnostics, research, and pathophysiology. In these roles, pathologists are well qualified and positioned to engage in conversations about animal use replacement, reduction, an
Autor:
Xingfeng Bao, Chi Zhang, Kuan-Chun Huang, Frank Fang, Dae-Shik Kim, Janna Hutz, Renee R. Hukkanen, Hyeong-Wook Choi, Vaishali Dixit, Kun Yu
Publikováno v:
Cancer Research. 80:592-592
Introduction: Calmette-Guerin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) is a significant unmet medical need. We report pharmacological, pharmacodynamic and pharmacogenomic characterization of E7766, a novel STING (stimulator of in
Autor:
Michael S. Thibodeau, Renee R. Hukkanen, Wendy G. Halpern, John Eighmy, Emily K. Meseck, James D Fikes, Daniel J. Patrick, Gerald G. Long, Sabine Francke, Charles E. Wood, Kenneth A Schafer
Publikováno v:
Toxicologic pathology. 46(3)
The severity grade is an important component of a histopathologic diagnosis in a nonclinical toxicity study that helps distinguish treatment-related effects from background findings and aids in determining adverse dose levels during hazard characteri
In mice, rats, and humans, there are three pairs of major salivary glands and numerous minor glands. Salivary secretions may be serous, mucous, or mixed, and they serve similar functions in mice and humans—to aid in digestion, taste, protection, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb574bf1dd268aafef86785abfd99082
https://doi.org/10.1016/b978-0-12-802900-8.00008-7
https://doi.org/10.1016/b978-0-12-802900-8.00008-7
Autor:
Mark J. Arends, Brad Bolon, Carmen J. Booth, Kelli L. Boyd, Cory F. Brayton, Bernard S. Buetow, Robert D. Cardiff, Stephan A. Carey, Cathy S. Carlson, Sindhu Cherian, Martha A. Delaney, Suzanne M. Dintzis, Renee Z. Dintzis, Philip Fleckman, Charles W. Frevert, Rochelle L. Garcia, Katherine N. Gibson-Corley, James J. Going, Paul C. Goodwin, Barry Gusterson, Catherine E. Hagan, Jack R. Harkema, Benjamin Hoch, Renee R. Hukkanen, Christopher Jerome, Sonali Jindal, Brian Johnson, C. Dirk Keene, Lloyd E. King, Sue E. Knoblaugh, Jolanta Kowalewska, Krista Marie DuBray La Perle, Michael A. Laflamme, Denny Liggitt, Michael A. Linden, David K. Meyerholz, Kathleen S. Montine, Thomas H. Morton, Atis Muehlenbachs, Lillian B. Nanney, Isabella Phan, Julie Randolph-Habecker, Mara H. Rendi, Arlin B. Rogers, Rani Sellers, Jessica M. Snyder, Carlos J. Suarez, John P. Sundberg, Henry J. Thompson, Maria Tretiakova, Piper M. Treuting, Lawrence True, Daniel C. Tu, Peter Vogel, James G. Wagner, Jerrold M. Ward, Rachel Wong, Caroline J. Zeiss, Alexander 'Sandy' D. Borowsky, Donna M. Bouley, Virginia L. Godfrey, Harm HogenEsch, Michael Leach, Dave Malarkey, Elisabeth McInnes, David Meyerholz, Alessandra Piersigilli, Cheryl Scudamore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c25a6417f6f6156e6cbc8d665a6bb00
https://doi.org/10.1016/b978-0-12-802900-8.00029-4
https://doi.org/10.1016/b978-0-12-802900-8.00029-4
Autor:
J. Craig Rowlands, Abraham Nyska, Robert A. Budinsky, Greg D. Martin, Marie Lawson, Russell S. Thomas, Renee R. Hukkanen, Debra K. Layko, Rosa Anna Manno, Andrea Grassetti, Joshua A. Harrill
Publikováno v:
Journal of Applied Toxicology. 36:802-814
Sustained activation of the aryl hydrocarbon receptor (AHR) is believed to be the initial key event in AHR receptor-mediated tumorigenesis in the rat liver. The role of AHR in mediating pathological changes in the liver prior to tumor formation was i