Výsledky vyhledávání - "Renee R. Handley"

Isolated nuclei from frozen tissue are the superior source for single cell RNA-seq compared with whole cells

Autor: Andrew Jiang, Klaus Lehnert, Suzanne J. Reid, Renee R. Handley, Jessie C. Jacobsen, Syke R. Rudiger, Clive J. McLaughlan, Paul J. Verma, C. Simon Bawden, Russell G. Snell

The isolation of intact single cells from frozen tissue is a challenge due to the mechanical and physical stress inflicted upon the cell during the freeze-thaw process. Ruptured cells release ambient RNA into the cell suspension, which can become enc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c9e89c452923eaa61b43761ee8c053c
https://doi.org/10.1101/2023.02.19.529150

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A new mechanism for a familiar mutation – bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement

Autor: Stephen R. Davis, Russell G. Snell, Thomas Lopdell, Mathew Littlejohn, Richard J. Spelman, Renee R. Handley, Tania Fink, Kathryn Tiplady, Thomas Johnson

Publikováno v: BMC Genomics, Vol 21, Iss 1, Pp 1-13 (2020)
BMC Genomics

Background The DGAT1 gene encodes an enzyme responsible for catalysing the terminal reaction in mammary triglyceride synthesis, and underpins a well-known pleiotropic quantitative trait locus (QTL) with a large influence on milk composition phenotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e33f18280894b7f2d00779b9ea4fb44
https://doi.org/10.1186/s12864-020-07004-z

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PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

Autor: Peter Heppner, Mike Dragunow, Thomas I. H. Park, Patrick Schweder, Miranda Aalderink, Natacha Coppieters, Richard L.M. Faull, Molly E. V. Swanson, Amy M. Smith, Pritika Narayan, Maurice A. Curtis, Deidre Jansson, Emma L. Scotter, Christopher C. Overall, Justin Rustenhoven, Leon Smyth, Renee R. Handley

Publikováno v: Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-16 (2018)
Molecular Neurodegeneration

Background Microglia play critical roles in the brain during homeostasis and pathological conditions. Understanding the molecular events underpinning microglial functions and activation states will further enable us to target these cells for the trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e489d865d7fb8a41ad0c877cee2b68
http://link.springer.com/article/10.1186/s13024-018-0277-1

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Once-daily milking during late lactation in pasture-fed dairy cows has minor effects on feed intake, body condition score gain, and hepatic gene expression

Autor: T.M. Grala, Jane K. Kay, C.V.C. Phyn, John R Roche, Renee R. Handley, Caroline G. Walker

Publikováno v: Journal of Dairy Science. 99:3041-3055

Milking cows once daily (1×) is a management practice occasionally used during mid/late lactation in pasture-based systems. It has been postulated that 1× milking will reduce dry matter intake (DMI) and increase body condition score (BCS) gain; how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72430c9a999aa74a23db1caaef9f205
https://doi.org/10.3168/jds.2015-10412

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A quantitative case study assessment of changes to hepatic metabolism from nonlactating grazing dairy cows consuming a large proportion of their diet as fodder beet

Autor: T.M. Grala, C.V.C. Phyn, D.E. Dalley, Renee R. Handley, John R Roche

Publikováno v: Journal of dairy science. 102(9)

Because of its high yield and the ability of cows to graze it in situ, fodder beet (FB) has become a popular crop in grazing systems, particularly for nonlactating cows. Due to its high sugar content, however, the transition to FB must be managed car

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b8741a0390f9a8752f738621338b13
https://pubmed.ncbi.nlm.nih.gov/31301843

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Brain urea increase is an early Huntington's disease pathogenic event observed in a prodromal transgenic sheep model and HD cases

Autor: Renee R, Handley, Suzanne J, Reid, Rudiger, Brauning, Paul, Maclean, Emily R, Mears, Imche, Fourie, Stefano, Patassini, Garth J S, Cooper, Skye R, Rudiger, Clive J, McLaughlan, Paul J, Verma, James F, Gusella, Marcy E, MacDonald, Henry J, Waldvogel, C Simon, Bawden, Richard L M, Faull, Russell G, Snell

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 114(52)

We present evidence for the presymptomatic dysregulation of urea metabolism in Huntington’s disease (HD). We identified increased levels of a urea transporter transcript and other osmotic regulators in the striatum of our prodromal sheep model of H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca11c89799110a8c1298c3a591fb000c
https://pubmed.ncbi.nlm.nih.gov/29229845

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Potential molecular consequences of transgene integration: The R6/2 mouse example

Autor: Alex Stortchevoi, Serkan Erdin, Colby Chiang, Carrie Hanscom, Jessie C. Jacobsen, Marcy E. MacDonald, Suzanne J. Reid, Carl Ernst, Russell G. Snell, James F. Gusella, Ian Blumenthal, Douglas Barker, Michael E. Talkowski, Renee R. Handley, A. Jennifer Morton

Publikováno v: Scientific Reports

Integration of exogenous DNA into a host genome represents an important route to generate animal and cellular models for exploration into human disease and therapeutic development. In most models, little is known concerning structural integrity of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce295a3e3cdd0af1ffe28b61d11ded7
http://europepmc.org/articles/PMC5264158

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Further Molecular Characterisation of the OVT73 Transgenic Sheep Model of Huntington's Disease Identifies Cortical Aggregates

Autor: Russell G. Snell, A. Jennifer Morton, Clive J. McLaughlan, Suzanne J. Reid, Marcy E. MacDonald, Richard L.M. Faull, Stefano Patassini, Henry J. Waldvogel, Jessie C Jacobsen, Renee R. Handley, Andreas Weiss, Alexander P. Osmand, James F. Gusella, C. Simon Bawden, Skye R. Rudiger

Publikováno v: Journal of Huntington's Disease. 2:279-295

Background: Huntington’s disease is a neurodegenerative disorder, typically with clinical manifestations in adult years, caused by an expanded polyglutamine-coding repeat in HTT. There are no treatments that delay or prevent the onset or progressio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa599777fb3a69f64f0d4fb4645e0f60
https://doi.org/10.3233/jhd-130067

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Metabolic disruption identified in the Huntington’s disease transgenic sheep model

Autor: Marcy E. MacDonald, Vladimir Obolonkin, Stefano Patassini, Henry J. Waldvogel, Russell G. Snell, Renee R. Handley, Richard L.M. Faull, Suzanne J. Reid, James F. Gusella, Jessie C. Jacobsen, Clive J. McLaughlan, C. Simon Bawden, Skye R. Rudiger

Publikováno v: Scientific Reports

Huntington’s disease (HD) is a dominantly inherited, progressive neurodegenerative disorder caused by a CAG repeat expansion within exon 1 of HTT, encoding huntingtin. There are no therapies that can delay the progression of this devastating diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b887b8b89ebba8f9973b4b17930457
https://doi.org/10.1038/srep20681

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