Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Renee Neades"'
Autor:
Flávia C. Costa, Halyna Fedosyuk, Renee Neades, Johana Bravo de Los Rios, Carlos F. Barbas, Kenneth R. Peterson
Publikováno v:
Anemia, Vol 2012 (2012)
Sickle cell disease (SCD) and β-thalassemia patients are phenotypically normal if they carry compensatory hereditary persistence of fetal hemoglobin (HPFH) mutations that result in increased levels of fetal hemoglobin (HbF, γ-globin chains) in adul
Externí odkaz:
https://doaj.org/article/d9636320f60e4fb4a162a69b6bcfb4d5
Autor:
Lesya Novikova, Flavia C. Costa, Halyna Fedosyuk, Kenneth R. Peterson, Matthew P Parker, Robert D. Winefield, Carolina A. Braghini, Renee Neades
Publikováno v:
Experimental biology and medicine (Maywood, N.J.). 241(7)
Fetal hemoglobin is a major genetic modifier of the phenotypic heterogeneity in patients with sickle cell disease and certain β-thalassemias. Normal levels of fetal hemoglobin postnatally are approximately 1% of total hemoglobin. Patients who have h
Publikováno v:
Blood. 114:2315-2322
When successful, human leukocyte antigen (HLA)–matched bone marrow transplantation with reduced-intensity conditioning is a cure for several nonmalignant hematologic disorders that require chronic transfusion, such as sickle cell disease and aplast
Publikováno v:
Molecular Carcinogenesis. 23:159-167
Exposure to solar ultraviolet (UV) radiation is believed to cause most human skin carcinomas. Despite the large body of evidence connecting UV exposure with skin cancer, the frequency and level of human exposure to repetitive doses of UV light will m
Publikováno v:
PLoS Genetics, Vol 8, Iss 12, p e1003155 (2012)
PLoS Genetics
PLoS Genetics
Activation of γ-globin gene expression in adults is known to be therapeutic for sickle cell disease. Thus, it follows that the converse, alleviation of repression, would be equally effective, since the net result would be the same: an increase in fe
Autor:
Renee Neades, Kenneth R. Peterson, Flávia C. Costa, Halyna Fedosyuk, Johana Bravo de los Rios, Carlos F. Barbas
Publikováno v:
Anemia
Anemia, Vol 2012 (2012)
Anemia, Vol 2012 (2012)
Sickle cell disease (SCD) andβ-thalassemia patients are phenotypically normal if they carry compensatory hereditary persistence of fetal hemoglobin (HPFH) mutations that result in increased levels of fetal hemoglobin (HbF,γ-globin chains) in adulth
Publikováno v:
Molecular and cellular biology. 28(10)
Autonomous silencing of -globin transcription is an important developmental regulatory mechanism controlling globin gene switching. An adult stage-specific silencer of the A -globin gene was identified between 730 and 378 relative to the mRNA start s
Autor:
Renee Neades, Kenneth R. Peterson, James Yan, C. Anthony Blau, Anna L. Bomhoff, Patrick A. Navas, Carlos F. Barbas
Publikováno v:
The Journal of biological chemistry. 280(44)
Identification of trans-acting factors or drugs capable of reactivating gamma-globin gene expression is complicated by the lack of suitable cell lines. Human K562 cells co-express epsilon- and gamma-globin but not beta-globin; transgenic mouse erythr
Autor:
Anuradha Roy, Betty S. Pace, Parmita Dalal, Flávia C. Costa, Lesya Zelenchuk, Renee Neades, Rathnam Chaguturu, Allen M. Chazelle, Halyna Fedosyuk, Kenneth R. Peterson, Andrea H. Fonteles, Biaoru Li
Publikováno v:
PLoS ONE
PLoS ONE, Vol 9, Iss 9, p e107006 (2014)
PLoS ONE, Vol 9, Iss 9, p e107006 (2014)
Decades of research have established that the most effective treatment for sickle cell disease (SCD) is increased fetal hemoglobin (HbF). Identification of a drug specific for inducing γ-globin expression in pediatric and adult patients, with minima
Autor:
Betty S. Pace, Anuradha Roy, Andrea H. Fonteles, Allen M. Chazelle, Rathnam Chaguturu, Melvin Reichman, Renee Neades, Kenneth R. Peterson, Preston S. Donover, Halyna Fedosyuk, Li Biaoru, Lesya Zelenchuk, Parmita Dalal, Flavia C Costa
Publikováno v:
Blood. 122:925-925
Decades of research has established that the most effective treatment for sickle cell disease (SCD) and Cooley’s anemia is increased fetal hemoglobin (HbF). Certain β-thalassemias may also benefit from fetal hemoglobin induction. Fetal hemoglobin