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pro vyhledávání: '"Renee M. Buchanan"'
IL-12-mediated increases in protection elicited by pneumococcal and meningococcal conjugate vaccines
Autor:
David E. Briles, Dennis W. Metzger, Bernard P. Arulanandam, M. A. Julie Westerink, Roberta Raeder, Renee M. Buchanan
Publikováno v:
Vaccine. 19:2020-2028
Interleukin-12 (IL-12) may be a beneficial adjuvant for augmenting vaccine efficacy against encapsulated bacteria such as Streptococcus pneumoniae and Neisseria meningitidis since it can stimulate production of interferon-gamma (IFN-gamma) and secret
Publikováno v:
The Journal of Immunology. 161:5525-5533
Polysaccharide vaccines to encapsulated bacteria such as Neisseria meningitidis and Streptococcus pneumoniae are weakly immunogenic due to their T-independent (TI) nature. Even when converted to T-dependent forms through conjugation to foreign protei