Examination of candidate exonic variants for association to Alzheimer disease in the Amish.

Autor: Laura N D'Aoust, Anna C Cummings, Renee Laux, Denise Fuzzell, Laura Caywood, Lori Reinhart-Mercer, William K Scott, Margaret A Pericak-Vance, Jonathan L Haines

Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0118043 (2015)

Alzheimer disease (AD) is the most common cause of dementia. As with many complex diseases, the identified variants do not explain the total expected genetic risk that is based on heritability estimates for AD. Isolated founder populations, such as t

Externí odkaz: https://doaj.org/article/4dace607999c4f86a08e2b68a2b16735

The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish

Autor: Sharlene D. Herington, Jonathan L. Haines, Sherri D Hochstetler, Jeffery M. Vance, Renee Laux, Yeunjoo E. Song, Jason E. Clouse, Michael D. Osterman, Leighanne R. Main, William K. Scott, Alan J. Lerner, Daniel A. Dorfsman, Sarada Fuzzell, Susan Slifer, Paula Ogrocki, Laura Caywood, Kristy Miskimen, Jairo Ramos, Audrey Lynn, Michael L. Cuccaro, Margaret A. Pericak-Vance, Michael Prough, Larry D. Adams, M. Denise Fuzzell

Publikováno v: HGG advances. 3(3)

Alzheimer disease (AD) is the most common type of dementia and is currently estimated to affect 6.2 million Americans. It ranks as the sixth leading cause of death in the United States and the proportion of deaths due to AD has been increasing since

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34a30bc204258560fee1bfdd7c83030
https://pubmed.ncbi.nlm.nih.gov/35599847

Genetic variants in the SHISA6 gene are associated with delayed cognitive impairment in two family datasets

Autor: Jeffery M. Vance, Larry D. Adams, St.George-Hyslop Ph, Yq Song, Sharlene D. Herington, Laura Caywood, Michael L. Cuccaro, Fuzzell, Jairo Ramos, Zaman Af, Leighanne R. Main, Laframboise O, Sarada Fuzzell, Tatiana Foroud, Michael Prough, Patrice L. Whitehead, Haines Jl, Hochstetler Sd, Jason E. Clouse, Renee Laux, Osterman, Paula Ogrocki, Richard Mayeux, Susan Slifer, Margaret A. Pericak-Vance, Alan J. Lerner, William K. Scott, Kristy Miskimen

BackgroundStudies of cognitive impairment (CI) in Amish communities have identified sibships containing multiple CI and cognitively unimpaired (CU; unaffected after age 75) individuals. We hypothesize that these CU individuals may carry protective al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22b5e7300b5091bf6bfab6c6d3b9a024
https://doi.org/10.1101/2021.07.02.21259940

The GGLEAM Study: Understanding Glaucoma in the Ohio Amish

Autor: Andrea R. Waksmunski, Sherri D. Miller, Jonathan M. Skarie, Jessica N. Cooke Bailey, Sarada Fuzzell, Tyler G. Kinzy, Jonathan L. Haines, Louis R. Pasquale, Yeunjoo E. Song, Renee Laux, Jane L. Sewell, Denise Fuzzell, Janey L. Wiggs

Publikováno v: International Journal of Environmental Research and Public Health, Vol 18, Iss 1551, p 1551 (2021)
International Journal of Environmental Research and Public Health
Volume 18
Issue 4

Glaucoma leads to millions of cases of visual impairment and blindness around the world. Its susceptibility is shaped by both environmental and genetic risk factors. Although over 120 risk loci have been identified for glaucoma, a large portion of it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdeb2933419735ab5180e309ee86dc6b
https://www.mdpi.com/1660-4601/18/4/1551

Search for protective genetic variants in Alzheimer disease in the U.S. Midwestern Amish

Autor: M. Denise Fuzzell, Michael Prough, Renee Laux, Laura Caywood, Kristy Miskimen, Audrey Lynn, Jason E. Clouse, Alan J. Lerner, Jane L. Sewell, Sharlene D. Herington, Jonathan L. Haines, Margaret A. Pericak-Vance, Michael L. Cuccaro, Paula Ogrocki, Leighanne R. Main, Sarada Fuzzell, Jeffery M. Vance, Yeunjoo E. Song, Bill Scott, Larry D. Adams

Publikováno v: Alzheimer's & Dementia. 16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ff551978dba75ebca24e880aa0b784c
https://doi.org/10.1002/alz.045350