Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Renee L. Sears"'
Autor:
Binsheng Gong, Dan Li, Yifan Zhang, Rebecca Kusko, Samir Lababidi, Zehui Cao, Mingyang Chen, Ning Chen, Qiaochu Chen, Qingwang Chen, Jiacheng Dai, Qiang Gan, Yuechen Gao, Mingkun Guo, Gunjan Hariani, Yujie He, Wanwan Hou, He Jiang, Garima Kushwaha, Jian-Liang Li, Jianying Li, Yulan Li, Liang-Chun Liu, Ruimei Liu, Shiming Liu, Edwin Meriaux, Mengqing Mo, Mathew Moore, Tyler J. Moss, Quanne Niu, Ananddeep Patel, Luyao Ren, Nedda F. Saremi, Erfei Shang, Jun Shang, Ping Song, Siqi Sun, Brent J. Urban, Danke Wang, Shangzi Wang, Zhining Wen, Xiangyi Xiong, Jingcheng Yang, Lihui Yin, Chao Zhang, Ruolan Zhang, Ambica Bhandari, Wanshi Cai, Agda Karina Eterovic, Dalila B. Megherbi, Tieliu Shi, Chen Suo, Ying Yu, Yuanting Zheng, Natalia Novoradovskaya, Renee L. Sears, Leming Shi, Wendell Jones, Weida Tong, Joshua Xu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Accurate indel calling plays an important role in precision medicine. A benchmarking indel set is essential for thoroughly evaluating the indel calling performance of bioinformatics pipelines. A reference sample with a set of known-positive
Externí odkaz:
https://doaj.org/article/f6ac02a15b704d26872b588b34da0a59
Autor:
Jia Zhou, Renee L. Sears, Xiaoyun Xing, Bo Zhang, Daofeng Li, Nicole B. Rockweiler, Hyo Sik Jang, Mayank N.K. Choudhary, Hyung Joo Lee, Rebecca F. Lowdon, Jason Arand, Brianne Tabers, C. Charles Gu, Theodore J. Cicero, Ting Wang
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-17 (2017)
Abstract Background Uncovering mechanisms of epigenome evolution is an essential step towards understanding the evolution of different cellular phenotypes. While studies have confirmed DNA methylation as a conserved epigenetic mechanism in mammalian
Externí odkaz:
https://doaj.org/article/bed260852cb4434482217c71d676d779
Publikováno v:
Nucleic Acids Research
The WashU Epigenome Browser (https://epigenomegateway.wustl.edu/) provides visualization, integration and analysis tools for epigenomic datasets. Since 2010, it has provided the scientific community with data from large consortia including the Roadma
Autor:
Yun Li, Jason A Chen, Renee L Sears, Fuying Gao, Eric D Klein, Anna Karydas, Michael D Geschwind, Howard J Rosen, Adam L Boxer, Weilong Guo, Matteo Pellegrini, Steve Horvath, Bruce L Miller, Daniel H Geschwind, Giovanni Coppola
Publikováno v:
PLoS Genetics, Vol 10, Iss 3, p e1004211 (2014)
Little is known about how changes in DNA methylation mediate risk for human diseases including dementia. Analysis of genome-wide methylation patterns in patients with two forms of tau-related dementia--progressive supranuclear palsy (PSP) and frontot
Externí odkaz:
https://doaj.org/article/be5330c2212d48809959e1b4a1261f1c
Autor:
Daniel Nachun, Deepika Dokuru, Zhongan Yang, Fying Gao, A. Boxer, Renee L. Sears, Joel H. Kramer, Anna Karydas, Eliana Marisa Ramos, V. Van Berlo, Giovanni Coppola, Howard H. Rosen, Bruce L. Miller
The role of peripheral inflammation in dementia is an important but complex topic. We present here the largest cohort of peripheral blood gene expression data ever assembled from patients with dementia and matching controls. Importantly, this cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4251e5f05bbbeac14b22642235098c4c
https://doi.org/10.1101/2019.12.13.875112
https://doi.org/10.1101/2019.12.13.875112
Autor:
Renee L. Sears, Jia Zhou
Publikováno v:
Current Pharmacology Reports. 4:314-325
This review article provides an overview of the bioinformatics frameworks developed in recent years that will facilitate analysis and promote the application of stem cells to medical research. High-throughput profiling techniques at the transcript, e
Autor:
Giovanni Coppola, Fuying Gao, Susan Perlman, Jennifer M. Farmer, Deepika Dokuru, Charles J. Isaacs, Zhongan Yang, Cassandra J Strawser, Daniel Nachun, David A. Lynch, Victoria Van Berlo, Renee L. Sears
Publikováno v:
Human Molecular Genetics
Human molecular genetics, vol 27, iss 17
Human molecular genetics, vol 27, iss 17
Transcriptional changes in Friedreich’s ataxia (FRDA), a rare and debilitating recessive Mendelian neurodegenerative disorder, have been studied in affected but inaccessible tissues—such as dorsal root ganglia, sensory neurons and cerebellum—in
Autor:
Ting Wang, Theodore J. Cicero, Daofeng Li, Rebecca F. Lowdon, Hyung Joo Lee, Jia Zhou, Nicole B. Rockweiler, Mayank N. K. Choudhary, Hyo Sik Jang, C. Charles Gu, Bo Zhang, Renee L. Sears, Xiaoyun Xing, Brianne Tabers, Jason Arand
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-17 (2017)
BMC Genomics
BMC Genomics
Background Uncovering mechanisms of epigenome evolution is an essential step towards understanding the evolution of different cellular phenotypes. While studies have confirmed DNA methylation as a conserved epigenetic mechanism in mammalian developme
Autor:
Bo Zhang, Renee L. Sears, Susan J. Fisher, Martin Hirst, Guangfeng Zhao, Joshua F. Robinson, Michael T. McMaster, Ting Wang, Joseph F. Costello, Steven J.M. Jones, Marco A. Marra, M. Yvonne Kim, Gi Nell Elliot, Mirhan Kapidzic, Rebecca F. Lowdon, Emily G. Hamilton, Yan Zhou, Chibo Hong, Matthew Gormley, Tali Mazor, Erica C. Pehrsson, Misha Bilenky, Daofeng Li
Publikováno v:
Developmental cell, vol 56, iss 9
The human placenta and its specialized cytotrophoblasts rapidly develop, have a compressed lifespan, govern pregnancy outcomes, and program the offspring's health. Understanding the molecular underpinnings of these behaviors informs development and d
Autor:
Shai Porat, Eric Klein, Naira Goukasian, Jennifer Eastman, Nouchee Vang, Liana G. Apostolova, Sona Hurtz, Renee L. Sears, Kristy S. Hwang, Giovanni Coppola, Benjamin Wang, Leslie Ramirez
Publikováno v:
Neurobiology of Aging. 39:82-89
The precise physiologic function of many of the recently discovered Alzheimer's disease risk variants remains unknown. The downstream effects of genetic variants remain largely unexplored. We studied the relationship between the top 10 non-APOE genes