Výsledky vyhledávání - "Renee L. Greer"

Akademický článek

Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

Autor: Renee L. Greer, Xiaoxi Dong, Ana Carolina F. Moraes, Ryszard A. Zielke, Gabriel R. Fernandes, Ekaterina Peremyslova, Stephany Vasquez-Perez, Alexi A. Schoenborn, Everton P. Gomes, Alexandre C. Pereira, Sandra R. G. Ferreira, Michael Yao, Ivan J. Fuss, Warren Strober, Aleksandra E. Sikora, Gregory A. Taylor, Ajay S. Gulati, Andrey Morgun, Natalia Shulzhenko

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

Mice deficient in the pro-inflammatory cytokine IFNγ have improved glucose tolerance. Here, the authors show that this effect depends on the gut microbeAkkermansia muciniphila, whose abundance increases in the absence IFNγ, and which is known to ha

Externí odkaz: https://doaj.org/article/61494a965e404846a44ae00fc93376f4

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Akademický článek

Antibiotic-Induced Alterations in Gut Microbiota Are Associated with Changes in Glucose Metabolism in Healthy Mice

Autor: Richard R. Rodrigues, Renee L. Greer, Xiaoxi Dong, Karen N. DSouza, Manoj Gurung, Jia Y. Wu, Andrey Morgun, Natalia Shulzhenko

Publikováno v: Frontiers in Microbiology, Vol 8 (2017)

The gut microbiome plays an important role in health and disease. Antibiotics are known to alter gut microbiota, yet their effects on glucose tolerance in lean, normoglycemic mice have not been widely investigated. In this study, we aimed to explore

Externí odkaz: https://doaj.org/article/48e44a872c3f4404be6ce779d6adc358

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Akademický článek

Dynamic Proteomic Analysis of Pancreatic Mesenchyme Reveals Novel Factors That Enhance Human Embryonic Stem Cell to Pancreatic Cell Differentiation

Autor: Holger A. Russ, Limor Landsman, Christopher L. Moss, Roger Higdon, Renee L. Greer, Kelly Kaihara, Randy Salamon, Eugene Kolker, Matthias Hebrok

Publikováno v: Stem Cells International, Vol 2016 (2016)

Current approaches in human embryonic stem cell (hESC) to pancreatic beta cell differentiation have largely been based on knowledge gained from developmental studies of the epithelial pancreas, while the potential roles of other supporting tissue com

Externí odkaz: https://doaj.org/article/5cffcfe0ec4f4e7591dee537d4620c0d

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Microbiota and adipocyte mitochondrial damage in type 2 diabetes are linked by Mmp12+ macrophages

Autor: Zhipeng Li, Manoj Gurung, Richard R. Rodrigues, Jyothi Padiadpu, Nolan K. Newman, Nathan P. Manes, Jacob W. Pederson, Renee L. Greer, Stephany Vasquez-Perez, Hyekyoung You, Kaito A. Hioki, Zoe Moulton, Anna Fel, Dominic De Nardo, Amiran K. Dzutsev, Aleksandra Nita-Lazar, Giorgio Trinchieri, Natalia Shulzhenko, Andrey Morgun

Publikováno v: Journal of Experimental Medicine. 219

Microbiota contribute to the induction of type 2 diabetes by high-fat/high-sugar (HFHS) diet, but which organs/pathways are impacted by microbiota remain unknown. Using multiorgan network and transkingdom analyses, we found that microbiota-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a11cd6fa816170bef5fceb54e756739
https://doi.org/10.1084/jem.20220017

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CVID enteropathy is characterized by exceeding low mucosal IgA levels and interferon-driven inflammation possibly related to the presence of a pathobiont

Autor: Stanislav V. Sosnovtsev, Natalia Shulzhenko, Manoj Gurung, Michael Yao, Dariia Vyshenska, Xiaoxi Dong, Stephany Vasquez-Perez, Ivan J. Fuss, Ekaterina Peremyslova, Martha Quezado, Warren Strober, Kim Montgomery-Recht, Andrey Morgun, Renee L. Greer

Publikováno v: Clinical Immunology. 197:139-153

Common variable immunodeficiency (CVID), the most common symptomatic primary antibody deficiency, is accompanied in some patients by a duodenal inflammation and malabsorption syndrome known as CVID enteropathy (E-CVID). The goal of this study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5881e2c9e08d12215f9d63a9cc2be84a
https://doi.org/10.1016/j.clim.2018.09.008

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Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes

Publikováno v: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Western diet (WD) is one of the major culprits of metabolic disease including type 2 diabetes (T2D) with gut microbiota playing an important role in modulating effects of the diet. Herein, we use a data-driven approach (Transkingdom Network analysis)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e03fa55283ea7d673dd57953cbc41c
https://doi.org/10.1038/s41467-020-20313-x

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Host response to cholestyramine can be mediated by the gut microbiota

Autor: Philip M. Monnier, Andrey Morgun, Nolan K. Newman, Stephany Vasquez-Perez, Manoj Gurung, Natalia Shulzhenko, Kaito A. Hioki, Kevin K. Brown, Renee L. Greer, Richard R. Rodrigues

The gut microbiome has been implicated as a major factor contributing to metabolic diseases as well as being contributors to the response to drugs used for the treatment of such diseases. In this study, using a diet-induced obesity mouse model, we te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1641d6ab96c83f6d5218a614874a2fd9
https://doi.org/10.1101/2020.12.08.416487

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Investigating a holobiont: Microbiota perturbations and transkingdom networks

Autor: Xiaoxi Dong, Renee L. Greer, Natalia Shulzhenko, Andrey Morgun

Publikováno v: Gut Microbes. 7:126-135

The scientific community has recently come to appreciate that, rather than existing as independent organisms, multicellular hosts and their microbiota comprise a complex evolving superorganism or metaorganism, termed a holobiont. This point of view l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b429c84a73762b512b7be0481b2fbed
https://doi.org/10.1080/19490976.2015.1128625

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Antibiotic-Induced Alterations in Gut Microbiota Are Associated with Changes in Glucose Metabolism in Healthy Mice

Autor: Manoj Gurung, Xiaoxi Dong, Andrey Morgun, Natalia Shulzhenko, Karen N. DSouza, Renee L. Greer, Jia Y. Wu, Richard R. Rodrigues

Publikováno v: Frontiers in Microbiology, Vol 8 (2017)
Frontiers in Microbiology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40dce127dd4f0b116a60f351d11a76ea

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Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

Autor: Ekaterina Peremyslova, Aleksandra E. Sikora, Stephany Vasquez-Perez, Xiaoxi Dong, Alexi A. Schoenborn, Gabriel Fernandes, Everton Padilha Gomes, Alexandre C. Pereira, Natalia Shulzhenko, Warren Strober, Gregory A. Taylor, Renee L. Greer, Andrey Morgun, Ajay S. Gulati, Ivan J. Fuss, Ana Carolina Franco de Moraes, Sandra Roberta Gouvea Ferreira, Ryszard A. Zielke, Michael Yao

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Cross-talk between the gut microbiota and the host immune system regulates host metabolism, and its dysregulation can cause metabolic disease. Here, we show that the gut microbe Akkermansia muciniphila can mediate negative effects of IFNγ on glucose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09833a821730f6b358ac497d25f264d
https://pubmed.ncbi.nlm.nih.gov/27910881

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