Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Renee L, DesJarlais"'
Autor:
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael P. Maher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. ASIC gating is modulated by divalent cations as well as small molecules; however, the molecular determinants of gating modulation by d
Externí odkaz:
https://doaj.org/article/7532453b22314d01ada9b275f434a0b8
Autor:
Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, David Lin, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael Maher
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Liu et al study the molecular and structural mechanism of the modulation of ASIC1 channel gating using functional, crystallographic, computational and mutational approaches. They identify small molecules that allosterically stabilize the closed state
Externí odkaz:
https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a
Autor:
Guozhang Xu, Zhijie Liu, Xinkang Wang, Tianbao Lu, Renee L. DesJarlais, Tho Thieu, Jing Zhang, Zheng Huang Devine, Fuyong Du, Qiu Li, Cynthia M. Milligan, Paul Shaffer, Peder E. Cedervall, John C. Spurlino, Christopher F. Stratton, Beth Pietrak, Lawrence M. Szewczuk, Victoria Wong, Ruth A. Steele, Wouter Bruinzeel, Madhu Chintala, Jose Silva, Michael D. Gaul, Mark J. Macielag, Ravi Nargund
Publikováno v:
Journal of medicinal chemistry. 65(15)
Activated factor XI (FXIa) inhibitors are promising novel anticoagulants with low bleeding risk compared with current anticoagulants. The discovery of potent FXIa inhibitors with good oral bioavailability has been challenging. Herein, we describe our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97b97b82cd74e1de0878b0437d2311e
https://pubmed.ncbi.nlm.nih.gov/35862732
https://pubmed.ncbi.nlm.nih.gov/35862732
Autor:
Jason C. Rech, Bruce L. Grasberger, Michael A. Letavic, Jinquan Luo, Changlu Liu, Jichun Ma, Michael P. Maher, Renee L. DesJarlais, Jeffrey Schoellerman, Rebecca Hagan, Yi Liu, Robyn L. Miller, David Lin
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology
Communications Biology
Acid-sensing ion channels (ASICs) are proton-gated cation channels critical for neuronal functions. Studies of ASIC1, a major ASIC isoform and proton sensor, have identified acidic pocket, an extracellular region enriched in acidic residues, as a key
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcb9a64556aa30386ccae13fe0c1e06
https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a
https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a
Autor:
Edward C. Lawson, Kiran Kumar, Renee L. DesJarlais, Soyon S Hwang, Scott D. Kuduk, Lindsey G. DeRatt
Publikováno v:
Organic Letters. 22:5828-5832
A tandem one-pot reaction featuring a cross-coupling followed by an intramolecular oxetane ring opening by mild nucleophiles is reported. The overall transformation comprises a carbon-carbon bond formation along with a carbon-heteroatom bond construc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82bd011e69c2b16c957139505a218427
https://doi.org/10.1021/acs.orglett.0c01899
https://doi.org/10.1021/acs.orglett.0c01899
Autor:
Renee L. DesJarlais, Sebastian Salentin, Klavs F. Jensen, Tommi S. Jaakkola, Daniel J. Griffin, Daniel Rodriguez Greve, Li Xing, Richard I. Robinson, Justin S. Cisar, Xinjun Hou, Constantine Kreatsoulas, Jeffrey W. Johannes, Andrew Palmer, Christos A. Nicolaou, Juan C. Alvarez, Regina Barzilay, William H. Green, Thomas J. Struble, Connor W. Coley, Ola Engkvist, Brian R. Lahue, Milan Chytil, Scott P. Brown, Scott Alan Frank, Daniel J. Price, Georg Mogk, Miriam Mathea
Publikováno v:
Journal of Medicinal Chemistry
Artificial intelligence and machine learning have demonstrated their potential role in predictive chemistry and synthetic planning of small molecules; there are at least a few reports of companies employing in silico synthetic planning into their ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43527bb6f8e5a5f497ea36b932a4df7
https://doi.org/10.1021/acs.jmedchem.9b02120
https://doi.org/10.1021/acs.jmedchem.9b02120
Autor:
Renee L. DesJarlais, Tami Marrone, Jamie M. Schiffer, Amy Y. Shih, Taraneh Mirzadegan, Kelly L. Damm-Ganamet, Laura Pérez-Benito
Publikováno v:
Journal of Medicinal Chemistry. 63:1929-1936
The topic of gender equality within the United States workforce is receiving a great deal of attention. The field of chemistry is no exception and is increasingly focused on taking steps to achieve gender diversity within the chemistry workforce. Ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::714622272a902f3d98fc482c6a5dad2e
https://doi.org/10.1021/acs.jmedchem.9b01512
https://doi.org/10.1021/acs.jmedchem.9b01512
Autor:
Eduardo V. Mercado-Marin, Jim Na, Renee L. DesJarlais, Helena C. Steffens, Genesis M. Bacani, Mark Seierstad, De Michael Chung, Taraneh Mirzadegan, Mark S. Tichenor
Publikováno v:
ACS Med Chem Lett
[Image: see text] Drug discovery building blocks available commercially or within an internal inventory cover a diverse range of chemical space and yet describe only a tiny fraction of all chemically feasible reagents. Vendors will eagerly provide to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e8eae69e6bffcbc5c1849a0bd619e3
https://europepmc.org/articles/PMC8591720/
https://europepmc.org/articles/PMC8591720/
Autor:
Hugo Ceulemans, Martin J Dellwo, Renee L. DesJarlais, Ann Vos, Kiran Kumar, Keith McCormick, Denise Morrison, Dmitrii Rassokhin, Vladimir Chupakhin, Eric Paternoster
Publikováno v:
Future medicinal chemistry. 13(19)
Background: Accurate prediction of absorption, distribution, metabolism and excretion (ADME) properties can facilitate the identification of promising drug candidates. Methodology & Results: The authors present the Janssen generic Target Product Prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e976378d5a2549de6a8fde1b1723f5
https://pubmed.ncbi.nlm.nih.gov/34528444
https://pubmed.ncbi.nlm.nih.gov/34528444
Autor:
Hua-Rong Lu, Ioanna Petrounia, Zhijie Liu, Daniel Jason Krosky, Devine Zheng Huang, Guozhang Xu, John Spurlino, Michael David Gaul, Weixue Wang, An Hermans, June Zhi Xu, Cynthia M. Milligan, Jenson Qi, Renee L. DesJarlais
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(23)
G-protein coupled receptor kinase 2 (GRK2), which is upregulated in the failing heart, appears to play a critical role in heart failure (HF) progression in part because enhanced GRK2 activity promotes dysfunction of β-adrenergic signaling and myocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52110a2ca5137d576a970f201881f77
https://pubmed.ncbi.nlm.nih.gov/33038544
https://pubmed.ncbi.nlm.nih.gov/33038544