Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Renee J. Primus"'
Autor:
Hutchison Alan J, Kover Renata X, Robbin Brodbeck, Xiao-Shu He, Andrew Thurkauf, Kevin J. Hodgetts, Andrzej Kieltyka, Stanislaw Rachwal, Xiaoyan Zhang, John R. Peterson, Jan W. F. Wasley, Renee J. Primus, He Zhao
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3105-3109
Optimization of the lead compound 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 by systematic structure-activity relation (SAR) studies lead to two potent compounds 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb02ce198fbc302c0f8d14590d286292
https://doi.org/10.1016/s0960-894x(02)00655-8
https://doi.org/10.1016/s0960-894x(02)00655-8
Autor:
Xiao-Shu He, Andrew Thurkauf, Andrzej Kieltyka, Jan W. F. Wasley, Robbin Brodbeck, He Zhao, Diane C. Hoffman, Renee J. Primus
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3111-3115
A series of chiral benzylpiperazinyl-1-(2,3-dihydro-indol-1-yl)ethanone derivatives were prepared and examined for their affinity at dopamine D2 and D4 receptors. Three compounds having D2/D4 affinity ratios approximating that found for the atypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e0fd275bd4e4a19ae2bd12af99f435
https://doi.org/10.1016/s0960-894x(02)00656-x
https://doi.org/10.1016/s0960-894x(02)00656-x
Publikováno v:
Molecular Brain Research. 58:74-82
Guanylyl 5′-[γ[ 35 S ]thio]-triphosphate (GTPγ[ 35 S ]) binding to NPY receptor-activated G-proteins was measured in adult rat brain sections in order to determine the neuroanatomical distribution of NPY receptor subtypes. Using the pharmacologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cab6bea02b6ae1633bb1855be8e376f
https://doi.org/10.1016/s0169-328x(98)00083-7
https://doi.org/10.1016/s0169-328x(98)00083-7
Autor:
Renee J. Primus, Robbin Brodbeck, Andrew Thurkauf, Xi Chen, Jan W. F. Wasley, Julia Braun, Jun Yuan
Publikováno v:
ChemInform. 30
N-(4-[4-{2,3-dichlorophenyl}-1-piperazinyl]butyl)-3-fluorenylcarboxamide and N-(4-[4-{2,3-dichlorophenyl}-1-piperazinyl]butyl)-2-biphenylenylcarboxamide were prepared in several steps from 2,3-dichloroaniline. These compounds were identified as highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::936aab51f14787f50c76c467a323b921
https://doi.org/10.1002/chin.199905137
https://doi.org/10.1002/chin.199905137
Publikováno v:
Molecular Brain Research. 14:179-185
The ratio of mRNA not selected for polyadenylation (non-poly(A)+ selected) to mRNA selected for polyadenylation (poly(A)+) for the β1, α1 and γ2 subunits of the GABAA receptor complex was examined in rats as a function of age. RNA was extracted fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771253faef81923f786a792c9badf08f
https://doi.org/10.1016/0169-328x(92)90172-8
https://doi.org/10.1016/0169-328x(92)90172-8
Autor:
Dorothy W. Gallager, Renee J. Primus
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 226:21-28
Levels of mRNA for the alpha 1, gamma 2 and beta 1 subunits of the GABAA receptor complex were examined in rats maintained on a chronic, continuous schedule of exposure to the benzodiazepine inverse agonist FG 7142. The effect of chronic exposure to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb0180eb01cf2924abe53941c9629ce
https://doi.org/10.1016/0922-4106(92)90078-a
https://doi.org/10.1016/0922-4106(92)90078-a
Publikováno v:
European Journal of Pharmacology. 196:223-231
Experiments examining seizure sensitivity were conducted on adult male offspring exposed to diazepam at 1.0 or 2.5 mg/kg per day in utero over gestational days 14-20. Threshold dosages to facial clonus, myoclonic jerk, clonic seizure, and extensor to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d25781241ebdd005512e1468282c8a6
https://doi.org/10.1016/0014-2999(91)90434-r
https://doi.org/10.1016/0014-2999(91)90434-r
Autor:
Renee J. Primus, Robbin Brodbeck, Julia Braun, Jun Yuan, Jan W. F. Wasley, Andrew Thurkauf, Xi Chen
Publikováno v:
Bioorganicmedicinal chemistry letters. 8(19)
N-(4-[4-{2,3-dichlorophenyl}-1-piperazinyl]butyl)-3-fluorenylcarboxamide and N-(4-[4-{2,3-dichlorophenyl}-1-piperazinyl]butyl)-2-biphenylenylcarboxamide were prepared in several steps from 2,3-dichloroaniline. These compounds were identified as highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e38c7a64ce09420dabcfef4391f28b7
https://pubmed.ncbi.nlm.nih.gov/9873609
https://pubmed.ncbi.nlm.nih.gov/9873609
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 17(5)
The regional distribution of corticotropin-releasing factor1 (CRF1) and CRF2 binding sites was assessed autoradiographically in adult rat brain. The differential pharmacological profiles of the CRF1 and CRF2 receptor subtypes were used for the discri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da04bb37b658aa8a6965de607a36cc0f
https://pubmed.ncbi.nlm.nih.gov/9348546
https://pubmed.ncbi.nlm.nih.gov/9348546
Autor:
Kevin A. Sevarino, Renee J. Primus
Publikováno v:
Journal of neurochemistry. 60(3)
Clinical and preclinical evidence supports a possible role for thyrotropin-releasing hormone (TRH) in cocaine action. However, the interaction between cocaine and TRH has not been directly examined. In the following report we describe a solution hybr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3293bc307b41205c164771c55fb2746e
https://pubmed.ncbi.nlm.nih.gov/8436966
https://pubmed.ncbi.nlm.nih.gov/8436966