Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Renee Gloury"'
Autor:
Mayura V. Wagle, Stephin J. Vervoort, Madison J. Kelly, Willem Van Der Byl, Timothy J. Peters, Ben P. Martin, Luciano G. Martelotto, Simone Nüssing, Kelly M. Ramsbottom, James R. Torpy, Deborah Knight, Sinead Reading, Kevin Thia, Lisa A. Miosge, Debbie R. Howard, Renee Gloury, Sarah S. Gabriel, Daniel T. Utzschneider, Jane Oliaro, Jonathan D. Powell, Fabio Luciani, Joseph A. Trapani, Ricky W. Johnstone, Axel Kallies, Christopher C. Goodnow, Ian A. Parish
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Exhausted T cells arise when chronic activation triggers functional defects. Here the authors show that chronic antigenic stimulation in both tumour and infection models induces the expression of EGR2, which drives and stabilises exhausted cell epige
Externí odkaz:
https://doaj.org/article/835402bfc1a5448994d0c742c77cfabd
Autor:
Tom Sidwell, Yang Liao, Alexandra L. Garnham, Ajithkumar Vasanthakumar, Renee Gloury, Jonas Blume, Peggy P. Teh, David Chisanga, Christoph Thelemann, Fabian de Labastida Rivera, Christian R. Engwerda, Lynn Corcoran, Kohei Kometani, Tomohiro Kurosaki, Gordon K. Smyth, Wei Shi, Axel Kallies
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
The transcription factor Bach2 is critical for T cell differentiation, but how it functions in Treg cells is unclear. Here the authors use a Treg-specific mouse model to show that Bach2 controls homeostasis and function of Treg cells by limiting DNA
Externí odkaz:
https://doaj.org/article/603dfe4ffed14153a4ca1bede6c41d3e
Autor:
Christina Lückel, Felix Picard, Hartmann Raifer, Lucia Campos Carrascosa, Anna Guralnik, Yajuan Zhang, Matthias Klein, Stefan Bittner, Falk Steffen, Sonja Moos, Federico Marini, Renee Gloury, Florian C. Kurschus, Ying-Yin Chao, Wilhelm Bertrams, Veronika Sexl, Bernd Schmeck, Lynn Bonetti, Melanie Grusdat, Michael Lohoff, Christina E. Zielinski, Frauke Zipp, Axel Kallies, Dirk Brenner, Michael Berger, Tobias Bopp, Björn Tackenberg, Magdalena Huber
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Dimethyl fumarate (DMF) is a therapy for multiple sclerosis (MS) with undetermined mechanism of action. Here the authors find that clinical response to DMF associates with decrease in IL-17-producing CD8+ T cells (Tc17), delineate molecular pathways
Externí odkaz:
https://doaj.org/article/2e2f0c2356834c5db881aabfe09b997c
Autor:
Ann Ly, Yang Liao, Halina Pietrzak, Lisa J. Ioannidis, Tom Sidwell, Renee Gloury, Marcel Doerflinger, Tony Triglia, Raymond Z. Qin, Joanna R. Groom, Gabrielle T. Belz, Kim L. Good-Jacobson, Wei Shi, Axel Kallies, Diana S. Hansen
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2257-2269.e6 (2019)
Summary: Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity against malaria are not fully understood. Using an infection model of severe malaria, we find that germinal center
Externí odkaz:
https://doaj.org/article/6f67331c6da645a1a983b3853dcaa0bf
Autor:
Ajithkumar Vasanthakumar, Yang Liao, Peggy Teh, Maria F. Pascutti, Anna E. Oja, Alexandra L. Garnham, Renee Gloury, Jessica C. Tempany, Tom Sidwell, Eloy Cuadrado, Paul Tuijnenburg, Taco W. Kuijpers, Najoua Lalaoui, Lisa A. Mielke, Vanessa L. Bryant, Philip D. Hodgkin, John Silke, Gordon K. Smyth, Martijn A. Nolte, Wei Shi, Axel Kallies
Publikováno v:
Cell Reports, Vol 20, Iss 12, Pp 2906-2920 (2017)
After exiting the thymus, Foxp3+ regulatory T (Treg) cells undergo further differentiation in the periphery, resulting in the generation of mature, fully suppressive effector (e)Treg cells in a process dependent on TCR signaling and the transcription
Externí odkaz:
https://doaj.org/article/a6158e2926c7412c92b606577bc61e39
Autor:
Axel Kallies, Wei Shi, Daniel T. Utzschneider, Sarah S. Gabriel, Renee Gloury, Ajithkumar Vasanthakumar, David Chisanga, Patrick M Gubser
Publikováno v:
Nature Immunology. 21:1256-1266
CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibitory receptors, including PD-1, and impaired cytokine production. Exhausted T cells are continuously replenished by T ce
Autor:
Alexandra L. Garnham, Christoph Thelemann, Lynn M. Corcoran, Kohei Kometani, Tom Sidwell, Wei Shi, David Chisanga, Christian R. Engwerda, Ajithkumar Vasanthakumar, Renee Gloury, Peggy P Teh, Gordon K. Smyth, Fabian de Labastida Rivera, Jonas Blume, Yang Liao, Tomohiro Kurosaki, Axel Kallies
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
Differentiation and homeostasis of Foxp3+ regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; however, molecular mechanisms that govern these processes are incompletely understood. Here we show that Bach2 is an importa
Autor:
Raymond Z. Qin, Joanna R Groom, Halina M. Pietrzak, Kim L. Good-Jacobson, Lisa J Ioannidis, Tom Sidwell, Ann Ly, Diana S. Hansen, Marcel Doerflinger, Axel Kallies, Wei Shi, Gabrielle T. Belz, Renee Gloury, Tony Triglia, Yang Liao
Publikováno v:
Cell Reports, Vol 29, Iss 8, Pp 2257-2269.e6 (2019)
Summary: Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity against malaria are not fully understood. Using an infection model of severe malaria, we find that germinal center
Autor:
Axel Kallies, Christopher C. Goodnow, Fabio Luciani, Ian A. Parish, Willem Van Der Byl, Ben P. Martin, Joseph A. Trapani, Simone Nüssing, Sarah S. Gabriel, Timothy J. Peters, Luciano G. Martelotto, Deborah A. Knight, James R. Torpy, Jane Oliaro, Debbie R. Howard, Kevin Y. T. Thia, Sinead Reading, Jonathan D. Powell, Ricky W. Johnstone, Renee Gloury, Daniel T. Utzschneider, Mayura V Wagle, Madison J. Kelly, Lisa A. Miosge, Kelly M Ramsbottom, Stephin J. Vervoort
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Chronic stimulation of CD8+ T cells triggers exhaustion, a distinct differentiation state with diminished effector function. Exhausted cells exist in multiple differentiation states, from stem-like progenitors that are the key mediators of the respon
Autor:
Mayura V, Wagle, Stephin J, Vervoort, Madison J, Kelly, Willem, Van Der Byl, Timothy J, Peters, Ben P, Martin, Luciano G, Martelotto, Simone, Nüssing, Kelly M, Ramsbottom, James R, Torpy, Deborah, Knight, Sinead, Reading, Kevin, Thia, Lisa A, Miosge, Debbie R, Howard, Renee, Gloury, Sarah S, Gabriel, Daniel T, Utzschneider, Jane, Oliaro, Jonathan D, Powell, Fabio, Luciani, Joseph A, Trapani, Ricky W, Johnstone, Axel, Kallies, Christopher C, Goodnow, Ian A, Parish
Publikováno v:
Nature communications. 12(1)
Chronic stimulation of CD8