Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Renee Doyle"'
Mechanisms regulating the loss of Tregs in HUPO mice that develop spontaneous inflammatory arthritis
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106734- (2023)
Summary: T regulatory cells (Tregs) are a potential therapeutic target in many autoimmune diseases including rheumatoid arthritis (RA). The mechanisms responsible for the maintenance of Tregs in chronic inflammatory conditions such as RA are poorly u
Externí odkaz:
https://doaj.org/article/e8297047994749859429bae8fb61939d
Autor:
Richard M. Pope, Qicong Sheng, Qi Quan Huang, Alexander V. Misharin, Renee Doyle, Shang Yang Chen, Qinwen Mao, Deborah R. Winter
Publikováno v:
Science Advances
Using a novel model of rheumatoid arthritis, we identified a critical role for reduced tissue-resident macrophages.
Little is known about the mechanisms regulating the transition of circulating monocytes into pro- or anti-inflammatory macrophage
Little is known about the mechanisms regulating the transition of circulating monocytes into pro- or anti-inflammatory macrophage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c04862da83e1effc53e707795db3dfd
https://doi.org/10.1126/sciadv.abd0515
https://doi.org/10.1126/sciadv.abd0515
Autor:
Bo Shi, Robert Birkett, Philip J. Homan, G. Kenneth Haines, Qi Quan Huang, Harris Perlman, Renee Doyle, Lianping Xing, Richard M. Pope
Publikováno v:
Arthritis & Rheumatology. 69:1762-1771
Objective: Macrophages are critical in the pathogenesis of rheumatoid arthritis (RA). We recently demonstrated that FLIP (FLICE-like inhibitory protein) is necessary for the differentiation and/or survival of macrophages. We also identified that FLIP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd2a40c756d7c81baa8170f6c79bff13
https://doi.org/10.1002/art.40151
https://doi.org/10.1002/art.40151
Autor:
Elyssa L. Roberts, Robert Birkett, Renee Doyle, Qinwen Mao, Bo Shi, Qi Quan Huang, Richard M. Pope
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(1)
The reduction of synovial tissue macrophages is a reliable biomarker for clinical improvement in patients with rheumatoid arthritis (RA), and macrophages are reduced in synovial tissue shortly after initiation of TNF inhibitors. The mechanism for thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52c52c11916fac2304b23349e4085de
https://pubmed.ncbi.nlm.nih.gov/29362465
https://pubmed.ncbi.nlm.nih.gov/29362465
Autor:
Bo Shi, Christian Stehlik, Robert Birkett, Qi Quan Huang, Richard M. Pope, Andrea Dorfleutner, Congcong He, Renee Doyle
We previously observed that SNAPIN, which is an adaptor protein in the SNARE core complex, was highly expressed in rheumatoid arthritis synovial tissue macrophages, but its role in macrophages and autoimmunity is unknown. To identify SNAPIN's role in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdd80952533f9ad66131a20c66a82cc
Autor:
Zan Huang, Qi Quan Huang, Renee Doyle, Deyu Fang, Syamal K. Datta, Quan Zhen Li, Hyewon Phee, Robert Birkett, Harris Perlman, Richard M. Pope, William H. Robinson, G. Kenneth Haines
Publikováno v:
Nature Communications
Dendritic cells (DCs) are critical for immune homeostasis. To target DCs, we generated a mouse line with Flip deficiency in cells that express cre under the CD11c promoter (CD11c-Flip-KO). CD11c-Flip-KO mice spontaneously develop erosive, inflammator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d65006242aacf4a0a0afd06191e223f9
https://doi.org/10.1038/ncomms8086
https://doi.org/10.1038/ncomms8086