Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Renee C. Roemmele"'
Autor:
Linli He, Melanie Marguerit, Roger P. Bakale, Shawn P. Allwein, Jason Rossi, James J. Reif, Yi Wang, Renee C. Roemmele, Gill Little
Publikováno v:
European Journal of Organic Chemistry. 2015:8003-8010
A total synthesis of enantiomerically pure [14C]-labelled (–)-homoharringtonine in 17 steps is reported. This synthetic process enabled the production of Good Manufacturing Practice (GMP) compliant (–)-[14C]homoharringtonine that was used in a hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ae56591f1fc2c09acd4501f446347e8
https://doi.org/10.1002/ejoc.201500906
https://doi.org/10.1002/ejoc.201500906
Publikováno v:
Organic Process Research & Development. 18:1427-1433
In the development of a new route to bendamustine hydrochloride, the API in Treanda, the key benzimidazole intermediate 5 was generated via catalytic heterogeneous hydrogenation of an aromatic nitro compound using a batch reactor. Because of safety c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf918b33bbe09c6281ffaf2c0fa4cb19
https://doi.org/10.1021/op400179f
https://doi.org/10.1021/op400179f
Publikováno v:
Organic Process Research & Development. 17:846-853
The evolution of the process to prepare CEP-32215, 3-(1′-cyclobutylspiro[4H-1,3-benzodioxine-2,4′-piperidine]-6-yl)-5,5-dimethyl-1,4-dihydropyridazine-6-one, is presented. Two routes detailing preparation of supplies for biological screening are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::731ff01148066e9b7b2f74f66ebfbe95
https://doi.org/10.1021/op400039d
https://doi.org/10.1021/op400039d
Autor:
Christie Michael, Renee C. Roemmele
Publikováno v:
Organic Process Research & Development. 17:422-426
CEP-18770 is an unstable peptide boronic acid and an amorphous solid, making it a challenging synthetic target. Process R&D led to a new process that avoided chromatography through crystalline inte...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dccbd9c74436caaa8b39c8019d46dc7f
https://doi.org/10.1021/op400010u
https://doi.org/10.1021/op400010u
Autor:
Shawn P. Allwein, Dale R. Mowrey, Renee C. Roemmele, Diane E. Gingrich, Roger P. Bakale, Daniel E. Petrillo, James J. Haley, James J. Reif
Publikováno v:
Organic Process Research & Development. 16:148-155
Evolution of the process strategies to prepare CEP-28122, an anaplastic lymphoma kinase (ALK) inhibitor, is presented. The initial medicinal chemistry route, used for the preparation of key supplie...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87652bb6c8d2133a00f6705e1d407d35
https://doi.org/10.1021/op200313v
https://doi.org/10.1021/op200313v
Publikováno v:
Organic Process Research & Development. 15:1063-1072
Process Research and Development activities leading to a new and efficient route to bendamustine hydrochloride, 1, the active ingredient in Treanda, a treatment for blood cancers, are disclosed. Two key features of this new process include a one-pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9999135a0416e82a5192df0be00daa7
https://doi.org/10.1021/op200176f
https://doi.org/10.1021/op200176f
Autor:
Linda Weinberg, Ted L. Underiner, Mark S. Albom, Craig A. Zificsak, Arup K. Ghose, Renee C. Roemmele, Mangeng Cheng, Karen L. Milkiewicz, Jay P. Theroff, Bruce D. Dorsey, Thelma S. Angeles
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:4351-4362
Dysregulation of the anaplastic lymphoma kinase (ALK) is implicated in a variety of cancers. A series of tetrahydropyrido[2,3-b]pyrazines was constructed as ring-constrained analogs of a known aminopyridine kinase scaffold. Chemistry was developed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1bddc45e141f6cd00dccf8a2e98b12a
https://doi.org/10.1016/j.bmc.2010.04.087
https://doi.org/10.1016/j.bmc.2010.04.087
Autor:
Don R. Baker, Joseph G. Fenyes, George P. Lahm, Thomas P. Selby, Thomas M. Stevenson, Karl J. Fisher, Ray A. Felix, Robert M. Oliver, Glynn Mitchell, Nigel J. Barnes, John M. Cox, Ian R. Matthews, David R. Parry, David P. J. Pearson, Stephen C. Smith, Gary M. Karp, A. Don Crews, Mark C. Manfredi, Axel Kleemann, Robert L. Arotin, Matthew L. Crawley, Brian Dahlke, Roger Baerg, Colin M. Tice, Adam C-T. Hsu, Lois M. Bryman, Renee C. Roemmele, Edward C. Taylor, Ping Zhou, Janusz Jurczak, Artur Jezewski, D. R. James, R. A. Felix, W. J. Michaely, C. J. Mathews, D. R. Baker, C. G. Knudsen, F. M. Pallos, J. M. Gerdes, S. Fitzjohn, T. H. Cromartie, S. W. Howard, D. P. Dagarin, M. Broadhurst, Joseph E. Drumm, Reed A. Coats, Frank T. Coppo, Stephen K. Gee, James V. Hay, Robert J. Pasteris, Gerard M. Koether, Xian J. Meng, M. P. Moon, Tho V. Thieu, Albert E. Casalnuovo, Rafael Shapiro, George Theodoridis, James T. Bahr, Scott Crawford, Benjamin Dugan, Frederick W. Hotzman, Lester L. Maravetz, Saroj Sehgel, Dominic P. Suarez, Charles R. Harrison, John P. Daub, Jef
Autor:
Henry Rapoport, Renee C. Roemmele
Publikováno v:
The Journal of Organic Chemistry. 53:2367-2371
Deprotection par reduction chimique: soit par le sodium dans l'ammoniac liquide, soit par l'acide bromhydrique dans l'acide acetique soit par electrolyse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a71326ed10fa2cae785787813b745c2
https://doi.org/10.1021/jo00245a049
https://doi.org/10.1021/jo00245a049