Výsledky vyhledávání - "Renee C. Bremer"

Uptake and timing of bilateral and contralateral risk-reducing mastectomy in women with Li–Fraumeni syndrome

Autor: Sharon A. Savage, Renee C. Bremer, Atara Siegel, William M. P. Klein, Payal P. Khincha, Jennifer T. Loud

Publikováno v: Breast Cancer Research and Treatment. 191:159-167

Women with Li–Fraumeni Syndrome (LFS) often consider risk-reducing mastectomy (RRM) due to extremely high risk of breast cancer at early ages. Data on uptake of RRM in LFS are scarce, and are inferred from experience in women with pathogenic varian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf44952a8cf7435af00e9c364d53187d
https://doi.org/10.1007/s10549-021-06410-5

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Family Health Leaders: Lessons on Living with Li‐Fraumeni Syndrome across Generations

Autor: Mark H. Greene, Allison Werner-Lin, Kevin Roy, Mae Carlson, Ashley Pantaleao, Maria Isabel Achatz, Sharon A. Savage, Jennifer L. Young, Payal P. Khincha, June A. Peters, Renee C. Bremer, Norman B. Epstein

Publikováno v: Fam Process

Li-Fraumeni Syndrome (LFS) is a hereditary disorder that confers an approximately 90% lifetime risk of cancer and requires comprehensive lifetime cancer screening. We explored healthcare roles for managing LFS-related cancer risks and treatments that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539b44f334394748ff8be2b30e274525
https://doi.org/10.1111/famp.12497

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Uptake and timing of bilateral and contralateral risk-reducing mastectomy in women with Li-Fraumeni syndrome

Autor: Atara, Siegel, Renee C, Bremer, William M P, Klein, Sharon A, Savage, Jennifer T, Loud, Payal P, Khincha

Publikováno v: Breast cancer research and treatment. 191(1)

Women with Li-Fraumeni Syndrome (LFS) often consider risk-reducing mastectomy (RRM) due to extremely high risk of breast cancer at early ages. Data on uptake of RRM in LFS are scarce, and are inferred from experience in women with pathogenic variants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc464fbe1f907697467697096c04f8b4
https://pubmed.ncbi.nlm.nih.gov/34652547

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Risk of skin cancer among patients with myotonic dystrophy type 1 based on primary care physician data from the U.K. Clinical Practice Research Datalink

Autor: Hanns Lochmüller, Lesley A. Anderson, Wilhelmine Meeraus, Rotana Alsaggaf, Nikoletta Nikolenko, Mark H. Greene, Ruth M. Pfeiffer, Youjin Wang, Shahinaz M. Gadalla, Julia C. Gage, Renee C. Bremer

Publikováno v: International Journal of Cancer. 142:1174-1181

Myotonic dystrophy type 1 (DM1) is an inherited multisystem neuromuscular disorder caused by a CTG trinucleotide repeat expansion in the DMPK gene. Recent evidence documents that DM1 patients have an increased risk of certain cancers, but whether ski

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d51dadd93773f0a008fdfebfbdb623d
https://doi.org/10.1002/ijc.31143

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Risks of first and subsequent cancers amongTP53mutation carriers in the National Cancer Institute Li-Fraumeni syndrome cohort

Autor: Sharon A. Savage, Renee C. Bremer, Philip S. Rosenberg, June A. Peters, Ana F. Best, Phuong L. Mai, Jennifer T. Loud, Payal P. Khincha, Rosamma DeCastro

Publikováno v: Cancer. 122:3673-3681

BACKGROUND Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition syndrome characterized by a very high lifetime cancer risk and an early age at diagnosis of a wide cancer spectrum. Precise estimates for the risk of first and subse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::583e5ac4e2d5f05010e02dae1220bdaf
https://doi.org/10.1002/cncr.30248

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Abstract 2036: The Bull's Eye: A research tool to characterize family, friends and social networks within a Li-Fraumeni Syndrome family

Autor: Renee C. Bremer, Megan N. Frone, Allison Werner-Lin, Jessica Bayer, Radhika Srivastava, Payal P. Khincha, Sharon A. Savage, Jennifer T. Loud

Publikováno v: Cancer Research. 80:2036-2036

Background:Li-Fraumeni Syndrome (LFS) is a rare autosomal dominant cancer predisposition syndrome associated with early age of onset and high lifetime risk of multiple malignancies. Pathogenic germline variants (PV) in TP53 cause ~70% of LFS. Our pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f59dfff33477798ef98675e13c3dd28
https://doi.org/10.1158/1538-7445.am2020-2036

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Easing the Burden: Describing the Role of Social, Emotional and Spiritual Support in Research Families with Li-Fraumeni Syndrome

Autor: Shannon Givens, Phuong L. Mai, Renee C. Bremer, Regina Kenen, Sharon A. Savage, June A. Peters

Publikováno v: Journal of Genetic Counseling. 25:529-542

This study presents findings of a mixed-method descriptive exploration of the role of friends and spirituality/religiosity in easing the burden of families with the rare inherited disorder, Li-Fraumeni Syndrome (LFS). LFS is caused by germline mutati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538218d0e42d8673d7ee6c020b62b7ab
https://doi.org/10.1007/s10897-015-9905-x

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Clinical Evaluation of Human Papillomavirus Screening With p16/Ki-67 Dual Stain Triage in a Large Organized Cervical Cancer Screening Program

Autor: Diane Tokugawa, Thomas Lorey, Kiranjit K. Grewal, Julie D. Kingery, Megan A. Clarke, Nancy Poitras, Patricia E. Goldhoff, Philip E. Castle, Nicolas Wentzensen, Renee C. Bremer, Alex Locke, Mark Schiffman, Walter Kinney

Publikováno v: JAMA Internal Medicine
JAMA Intern Med

Key Points Question What are efficient approaches for triage of human papillomavirus–positive women in cervical cancer screening? Findings This cohort study of 3225 women found that p16/Ki-67 dual stain, alone or in combination with human papilloma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3568f68dfb5efd850760103c52ba7ab8
https://doi.org/10.1001/jamainternmed.2019.0306

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Abstract 5296: Evaluation of p16/Ki-67 dual stain, cytology, and HPV16/18 genotyping for triage of HPV-positive women in a large screening population

Autor: Renee C. Bremer, Mark Schiffman, Thomas Lorey, Walter Kinney, Philip E. Castle, Barbara Fetterman, Diane Tokugawa, Nancy Poitras, Elizabeth M. Hosfield, Nicolas Wentzensen

Publikováno v: Cancer Research. 77:5296-5296

Objectives: Primary HPV testing has been approved in the United States. Screening intervals can be safely extended for HPV-negative women, but the challenge lies in discriminating transient HPV infections from precancers among HPV-positives. In a lar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79f54c20bedfab2dddd04cf5ce10353b
https://doi.org/10.1158/1538-7445.am2017-5296

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Abstract 3473: Psychosocial functioning in research participants at enrollment in a Li-Fraumeni syndrome study

Autor: Jennifer T. Loud, Renee C. Bremer, Rosamma DeCastro, Sharon A. Savage, Phuong L. Mai, June A. Peters

Publikováno v: Cancer Research. 76:3473-3473

Background: Li Fraumeni Syndrome (LFS) is an autosomal dominant cancer predisposition syndrome in which about 90% of individuals develop cancer by age 60. Approximately 70% of individuals with LFS have germline TP53 mutation. We hypothesized that thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbb7026ac7d43d27bfbb19b12a5dc700
https://doi.org/10.1158/1538-7445.am2016-3473

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