Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Renee C Ryals"'
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0241006 (2020)
Gene therapy is now an effective approach to treat many forms of retinal degeneration. Delivery agents that are cell-specific, allow for multiple dosing regimens, and have low immunogenicity are needed to expand the utility of gene therapy for the re
Externí odkaz:
https://doaj.org/article/791914c6d78048899fc0ed11685569cb
Autor:
Aaron S Coyner, Renee C Ryals, Cristy A Ku, Cody M Fischer, Rachel C Patel, Shreya Datta, Paul Yang, Yuquan Wen, René Hen, Mark E Pennesi
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159776 (2016)
To assess the neuroprotective effects of flibanserin (formerly BIMT-17), a dual 5-HT1A agonist and 5-HT2A antagonist, in a light-induced retinopathy model.Albino BALB/c mice were injected intraperitoneally with either vehicle or increasing doses of f
Externí odkaz:
https://doaj.org/article/58b04a535e554b66a5804b6129cfa245
Autor:
Shannon E Boye, Wei-Chieh Huang, Alejandro J Roman, Alexander Sumaroka, Sanford L Boye, Renee C Ryals, Melani B Olivares, Qing Ruan, Budd A Tucker, Edwin M Stone, Anand Swaroop, Artur V Cideciyan, William W Hauswirth, Samuel G Jacobson
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92928 (2014)
Mutations in the CEP290 (cilia-centrosomal protein 290 kDa) gene in Leber congenital amaurosis (LCA) cause early onset visual loss but retained cone photoreceptors in the fovea, which is the potential therapeutic target. A cone-only mouse model carry
Externí odkaz:
https://doaj.org/article/9bceffafe04b4e8ba21a5c75da5683f4
Autor:
Christine N Kay, Renee C Ryals, George V Aslanidi, Seok Hong Min, Qing Ruan, Jingfen Sun, Frank M Dyka, Daniel Kasuga, Andrea E Ayala, Kim Van Vliet, Mavis Agbandje-McKenna, William W Hauswirth, Sanford L Boye, Shannon E Boye
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62097 (2013)
Development of viral vectors capable of transducing photoreceptors by less invasive methods than subretinal injection would provide a major advancement in retinal gene therapy. We sought to develop novel AAV vectors optimized for photoreceptor transd
Externí odkaz:
https://doaj.org/article/acb82117f6a642269cce77147bb4a790
Autor:
Marco Herrera-Barrera, Renee C. Ryals, Milan Gautam, Antony Jozic, Madeleine Landry, Tetiana Korzun, Mohit Gupta, Chris Acosta, Jonathan Stoddard, Rene Reynaga, Wayne Tschetter, Nick Jacomino, Oleh Taratula, Conroy Sun, Andreas K. Lauer, Martha Neuringer, Gaurav Sahay
Publikováno v:
Science Advances. 9
Lipid nanoparticle (LNP)–based mRNA delivery holds promise for the treatment of inherited retinal degenerations. Currently, LNP-mediated mRNA delivery is restricted to the retinal pigment epithelium (RPE) and Müller glia. LNPs must overcome ocular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca7c9a4101372a54cbefd1669c6323a
https://doi.org/10.1126/sciadv.add4623
https://doi.org/10.1126/sciadv.add4623
Autor:
Harshini Surendran, Lalitha Soundararajan, Vijay Bhaskar Reddy K, Janavi Subramani, Jonathan Stoddard, Rene Reynaga, Wayne Tschetter, Renee C. Ryals, Rajarshi Pal
Publikováno v:
STAR protocols. 3(4)
We present an optimized protocol for guided differentiation of retinal pigment epithelium (RPE) cells from human-induced pluripotent stem cells (iPSC). De novo-generated RPE cells are mature, polarized, and mimic the cellular and molecular profile of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57bfe200667d6c7134ef2b29ce17704c
https://pubmed.ncbi.nlm.nih.gov/36386870
https://pubmed.ncbi.nlm.nih.gov/36386870
Publikováno v:
J Control Release
Retinal gene therapy has had unprecedented success in generating treatments that can halt vision loss. However, immunogenic response and long-term toxicity with the use of viral vectors remain a concern. Non-viral vectors are relatively non-immunogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d72ae9c0900e33826d7aabcfcd76095
https://doi.org/10.1016/j.jconrel.2019.04.015
https://doi.org/10.1016/j.jconrel.2019.04.015
Autor:
Chris Acosta, Renee C. Ryals, Madison McKinney, Siddharth Patel, Gaurav Sahay, Mark E. Pennesi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 10, p e0241006 (2020)
PLoS ONE, Vol 15, Iss 10, p e0241006 (2020)
Gene therapy is now an effective approach to treat many forms of retinal degeneration. Delivery agents that are cell-specific, allow for multiple dosing regimens, and have low immunogenicity are needed to expand the utility of gene therapy for the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234d7f580ade51d18751259e6a141a40
https://pubmed.ncbi.nlm.nih.gov/33119640
https://pubmed.ncbi.nlm.nih.gov/33119640
Autor:
Mark E. Pennesi, Dan Jiang, Bryan M. Robb, Renee C. Ryals, Daniel L. Marks, Hope Titus, Ribal A. Salam, Firas W. Saad, Kyle K. Weller, Paul Yang, Samuel J. Huang, Hytham Hammad
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose We determine if monomethyl fumarate (MMF) can protect the retina in mice subjected to light-induced retinopathy (LIR). Methods Albino BALB/c mice were intraperitoneally injected with 50 to 100 mg/kg MMF before or after exposure to bright whit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a370f6fd05b459942cf45b4af5cf43
https://pubmed.ncbi.nlm.nih.gov/30924852
https://pubmed.ncbi.nlm.nih.gov/30924852
Autor:
Paul Yang, Melanie B. Gillingham, William Steele, Shasank Bonthala, Mark E. Pennesi, Samuel J. Huang, Dahlia Wafai, Hope Titus, Renee C. Ryals, Makayla Six, Claire Bernert
Publikováno v:
Translational Vision Science & Technology
Purpose Treatments that delay retinal cell death regardless of genetic causation are needed for inherited retinal degeneration (IRD) patients. The ketogenic diet is a high-fat, low-carbohydrate diet, used to treat epilepsy, and has beneficial effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdbd98acd1a38ee755a88ff389fa059
https://doi.org/10.1167/tvst.9.11.18
https://doi.org/10.1167/tvst.9.11.18