Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Renee C Geck"'
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0232072 (2020)
The vasculature within a tumor is highly disordered both structurally and functionally. Endothelial cells that comprise the vasculature are poorly connected causing vessel leakage and exposing the endothelium to a hypoxic microenvironment. Therefore,
Externí odkaz:
https://doaj.org/article/28cef05febf0425997ec867350d5fbff
Publikováno v:
The American Journal of Human Genetics. 110:228-239
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83ebd5ff71c369675c7732832f40ae45
https://doi.org/10.1016/j.ajhg.2023.01.003
https://doi.org/10.1016/j.ajhg.2023.01.003
Autor:
Laura E. Stevens, Guillermo Peluffo, Xintao Qiu, Daniel Temko, Anne Fassl, Zheqi Li, Anne Trinh, Marco Seehawer, Bojana Jovanović, Maša Alečković, Callahan M. Wilde, Renee C. Geck, Shaokun Shu, Natalie L. Kingston, Nicholas W. Harper, Vanessa Almendro, Alanna L. Pyke, Shawn B. Egri, Malvina Papanastasiou, Kendell Clement, Ningxuan Zhou, Sarah Walker, Jacqueline Salas, So Yeon Park, David A. Frank, Alexander Meissner, Jacob D. Jaffe, Piotr Sicinski, Alex Toker, Franziska Michor, Henry W. Long, Beth A. Overmoyer, Kornelia Polyak
Publikováno v:
Cancer research : an official organ of the American Association for Cancer Research
Inflammatory breast cancer (IBC) is a difficult-to-treat disease with poor clinical outcomes due to high risk of metastasis and resistance to treatment. In breast cancer, CD44+CD24− cells possess stem cell-like features and contribute to disease pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5459b92ee82eba543f6d270b212317
https://doi.org/10.1158/0008-5472.can-22-0423
https://doi.org/10.1158/0008-5472.can-22-0423
Autor:
Christian C. Dibble, Samuel A. Barritt, Grace E. Perry, Evan C. Lien, Renee C. Geck, Sarah E. DuBois-Coyne, David Bartee, Thomas T. Zengeya, Emily B. Cohen, Min Yuan, Benjamin D. Hopkins, Jordan L. Meier, John G. Clohessy, John M. Asara, Lewis C. Cantley, Alex Toker
Publikováno v:
Nature. 608:192-198
In response to hormones and growth factors, the class I phosphoinositide-3-kinase (PI3K) signalling network functions as a major regulator of metabolism and growth, governing cellular nutrient uptake, energy generation, reducing cofactor production a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a671b67118b568aca77aca5b34c77ee1
https://doi.org/10.1038/s41586-022-04984-8
https://doi.org/10.1038/s41586-022-04984-8
Autor:
Alex Toker, Lewis C. Cantley, Volker Haucke, Olivier Elemento, Gerburg M. Wulf, Adrija J. Navarro, Renee C. Geck, Charles J. Murphy, Haibin Wang, Marcia N. Paddock, Hui Liu
Inactivation of the tumor suppressor lipid phosphatase INPP4B is common in triple-negative breast cancer (TNBC). We generated a genetically engineered TNBC mouse model deficient in INPP4B. We found a dose-dependent increase in tumor incidence in INPP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::357bcca46e2c93f3e33e1375b8c98521
https://doi.org/10.1158/2159-8290.c.6547936.v1
https://doi.org/10.1158/2159-8290.c.6547936.v1
Autor:
Alex Toker, Lewis C. Cantley, Volker Haucke, Olivier Elemento, Gerburg M. Wulf, Adrija J. Navarro, Renee C. Geck, Charles J. Murphy, Haibin Wang, Marcia N. Paddock, Hui Liu
Supplementary figures S1-S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2605a3dcd2fe33a411d24f33e1cf3ee2
https://doi.org/10.1158/2159-8290.22535743
https://doi.org/10.1158/2159-8290.22535743
Autor:
Alex Toker, Lewis C. Cantley, Volker Haucke, Olivier Elemento, Gerburg M. Wulf, Adrija J. Navarro, Renee C. Geck, Charles J. Murphy, Haibin Wang, Marcia N. Paddock, Hui Liu
Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::061bbf8323e8b62dd490e1e969a4be78
https://doi.org/10.1158/2159-8290.22535740
https://doi.org/10.1158/2159-8290.22535740
Autor:
Kornelia Polyak, Beth A. Overmoyer, Henry W. Long, Franziska Michor, Alex Toker, Piotr Sicinski, Jacob D. Jaffe, Alexander Meissner, David A. Frank, So Yeon Park, Jacqueline Salas, Sarah Walker, Ningxuan Zhou, Kendell Clement, Malvina Papanastasiou, Shawn B. Egri, Alanna L. Pyke, Vanessa Almendro, Nicholas W. Harper, Natalie L. Kingston, Shaokun Shu, Renee C. Geck, Callahan M. Wilde, Maša Alečković, Bojana Jovanović, Marco Seehawer, Anne Trinh, Zheqi Li, Anne Fassl, Daniel Temko, Xintao Qiu, Guillermo Peluffo, Laura E. Stevens
Supplementary Table S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84361361756a35e1845ed85708cfe093
https://doi.org/10.1158/0008-5472.22432920.v1
https://doi.org/10.1158/0008-5472.22432920.v1
Autor:
Kornelia Polyak, Beth A. Overmoyer, Henry W. Long, Franziska Michor, Alex Toker, Piotr Sicinski, Jacob D. Jaffe, Alexander Meissner, David A. Frank, So Yeon Park, Jacqueline Salas, Sarah Walker, Ningxuan Zhou, Kendell Clement, Malvina Papanastasiou, Shawn B. Egri, Alanna L. Pyke, Vanessa Almendro, Nicholas W. Harper, Natalie L. Kingston, Shaokun Shu, Renee C. Geck, Callahan M. Wilde, Maša Alečković, Bojana Jovanović, Marco Seehawer, Anne Trinh, Zheqi Li, Anne Fassl, Daniel Temko, Xintao Qiu, Guillermo Peluffo, Laura E. Stevens
Inflammatory breast cancer (IBC) is a difficult-to-treat disease with poor clinical outcomes due to high risk of metastasis and resistance to treatment. In breast cancer, CD44+CD24− cells possess stem cell-like features and contribute to disease pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e38085e743971c23ee150c9c79f673df
https://doi.org/10.1158/0008-5472.c.6514263.v1
https://doi.org/10.1158/0008-5472.c.6514263.v1
Autor:
Kornelia Polyak, Beth A. Overmoyer, Henry W. Long, Franziska Michor, Alex Toker, Piotr Sicinski, Jacob D. Jaffe, Alexander Meissner, David A. Frank, So Yeon Park, Jacqueline Salas, Sarah Walker, Ningxuan Zhou, Kendell Clement, Malvina Papanastasiou, Shawn B. Egri, Alanna L. Pyke, Vanessa Almendro, Nicholas W. Harper, Natalie L. Kingston, Shaokun Shu, Renee C. Geck, Callahan M. Wilde, Maša Alečković, Bojana Jovanović, Marco Seehawer, Anne Trinh, Zheqi Li, Anne Fassl, Daniel Temko, Xintao Qiu, Guillermo Peluffo, Laura E. Stevens
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339862a39c2f24d5e4537f8e37c813f4
https://doi.org/10.1158/0008-5472.22432929
https://doi.org/10.1158/0008-5472.22432929