Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Renecia A. Watkins"'
Autor:
Gail J Ocaña, Emily K Sims, Renecia A Watkins, Susanne Ragg, Kieren J Mather, Richard A Oram, Raghavendra G Mirmira, Linda A DiMeglio, Janice S Blum, Carmella Evans-Molina
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0208456 (2019)
Heat shock protein 90 (Hsp90) is a protein chaperone that is upregulated and released from pancreatic β cells under pro-inflammatory conditions. We hypothesized that serum Hsp90 may have utility as a biomarker of type 1 diabetes risk and exhibit ele
Externí odkaz:
https://doaj.org/article/3de17e1d6c344bb4b510ba3fa6794d7e
Autor:
Emily K. Sims, Renecia A. Watkins, Raghavendra G. Mirmira, Gail J. Ocaña, Carmella Evans-Molina, Richard A. Oram, Linda A. DiMeglio, Janice S. Blum, Kieren J. Mather, Susanne Ragg
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0208456 (2019)
PLoS ONE
PLoS ONE
Heat shock protein 90 (Hsp90) is a protein chaperone that is upregulated and released from pancreatic β cells under pro-inflammatory conditions. We hypothesized that serum Hsp90 may have utility as a biomarker of type 1 diabetes risk and exhibit ele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8db661903055d799710694891601748
https://doaj.org/article/3de17e1d6c344bb4b510ba3fa6794d7e
https://doaj.org/article/3de17e1d6c344bb4b510ba3fa6794d7e
Autor:
Renecia A. Watkins, Raghavendra G. Mirmira, Zunaira Chaudhry, Carmella Evans-Molina, Linda A. DiMeglio, Emily K. Sims, Fangqian Ouyang, Jay M. Sosenko, Susan M. Perkins, Farooq Syed, Janice S. Blum
Publikováno v:
Diabetes Care
OBJECTIVE We tested whether an elevation in the serum proinsulin–to–C-peptide ratio (PI:C), a biomarker of β-cell endoplasmic reticulum (ER) dysfunction, was associated with progression to type 1 diabetes. RESEARCH DESIGN AND METHODS Fasting tot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c349c86b3f2d552f08389e2f26a0dd7b
http://europepmc.org/articles/PMC5001142
http://europepmc.org/articles/PMC5001142
Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes
Autor:
Renecia A. Watkins, Marisa M. Fisher, Raghavendra G. Mirmira, Kieren J. Mather, Sarah A. Tersey, Naga Chalasani, Linda A. DiMeglio, Janice S. Blum, Carmella Evans-Molina
Publikováno v:
Diabetes
Elevated ratios of circulating unmethylated to methylated preproinsulin (INS) DNA have been suggested to reflect β-cell death in type 1 diabetes (T1D). We tested the hypothesis that absolute levels (rather than ratios) of unmethylated and methylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006f8fcf6d8549a4a2f81a858d59f100
https://doi.org/10.2337/db15-0430
https://doi.org/10.2337/db15-0430
Autor:
Rama Natarajan, Mina Patel-Chamberlin, Bancha Satirapoj, Lynetta Phillips, Ying Wang, Edouardo J. Nam, Renecia A. Watkins, Tahmina Haq, Cynthia C. Nast, Xiwei Wu, Aishe Leng, Kathleene Ulanday, Tiane Dai, Sharon G. Adler, Janine LaPage, Raimund Hirschberg
Publikováno v:
Kidney International. 79(10):1138-1148
We sought to find a urinary biomarker for chronic kidney disease and tested hematopoietic growth factor inducible neurokinin-1 (HGFIN, also known as Gpnmb/Osteoactivin) as it was found to be a kidney injury biomarker in microarray studies. Here, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd908db64e23cbcd261ba1e1063953e1
Publikováno v:
Translational research : the journal of laboratory and clinical medicine. 164(2)
Type 1 diabetes (T1D) is an autoimmune disease with a prolonged and variable latent period that culminates in the destruction of pancreatic β-cells and the development of hyperglycemia. There is a need for diagnostic biomarkers to detect more accura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f227d8b8e5e1f5035a6b003a8b05a01c
https://pubmed.ncbi.nlm.nih.gov/24662515
https://pubmed.ncbi.nlm.nih.gov/24662515
Autor:
Renecia A. Watkins, Raghavendra G. Mirmira, Jennifer Terrell, Carmella Evans-Molina, Linda A. DiMeglio, Ivan A. Restrepo, Janice S. Blum, Lynette Guindon, Kathleen H. Day
Publikováno v:
Translational Research. 168:96-106.e1
Rapid evaluation of therapies designed to preserve β cells in persons with type 1 diabetes (T1D) is hampered by limited availability of sensitive β-cell health biomarkers. In particular, biomarkers elucidating the presence and degree of β-cell str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82528a231d1191e99c56be2a89cd067c
https://doi.org/10.1016/j.trsl.2015.08.010
https://doi.org/10.1016/j.trsl.2015.08.010