Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rene Zangl"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
ATPases are the macromolecular machines for cellular energy production. Here the authors investigate factors that govern the assembly of the F1 complex from a bacterial F-type ATPase and relate differences in activity of complexes assembled in cells
Externí odkaz:
https://doaj.org/article/375ad572c3ca4c258f9689413fed4ceb
Autor:
Marius Friedrich, Lisa Schulz, Kamil Hofman, Rene Zangl, Nina Morgner, Saad Shaaban, Georg Manolikakes
Publikováno v:
Tetrahedron Chem, Vol 1, Iss , Pp 100003- (2022)
Heterocyclic sulfones and sulfonamides represent important structural motives in medicinal chemistry and drug development. Therefore, efficient and reliable methods for their construction from simple building blocks are in high demand. Herein we repo
Externí odkaz:
https://doaj.org/article/f500a02be4e247dbbdb6db75d46a0b2f
Autor:
Tobias Lieblein, Rene Zangl, Janosch Martin, Jan Hoffmann, Marie J Hutchison, Tina Stark, Elke Stirnal, Thomas Schrader, Harald Schwalbe, Nina Morgner
Publikováno v:
eLife, Vol 9 (2020)
The formation of oligomers of the amyloid-β peptide plays a key role in the onset of Alzheimer's disease. We describe herein the investigation of disease-relevant small amyloid-β oligomers by mass spectrometry and ion mobility spectrometry, reveali
Externí odkaz:
https://doaj.org/article/ba34516caffd466fb9295cff7f883d7f
Autor:
Nina Morgner, Rene Zangl
Publikováno v:
BIOspektrum. 27:705-708
The formation of amyloid-β oligomers plays a key role in the onset of Alzheimer’s disease. We investigated the aggregation of amyloid-β oligomers by mass spectrometry and ion mobility spectrometry, revealing those structural properties, which lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a498626dd296a8fec8de0e0dba58d95
https://doi.org/10.1007/s12268-021-1678-1
https://doi.org/10.1007/s12268-021-1678-1
Publikováno v:
Physical Chemistry Chemical Physics. 22:5463-5475
The calcium sensor protein calmodulin is ubiquitous among eukaryotes. It translates intracellular Ca2+ influx (by a decrease of conformational flexibility) into increased target recognition affinity. Here we demonstrate that by using the IR reporter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa69c22d7d20780592773e0ed553347
https://doi.org/10.1039/c9cp06808b
https://doi.org/10.1039/c9cp06808b
F-type ATP synthases are multiprotein complexes composed of two separate coupled motors (F1 and FO) generating adenosine triphosphate (ATP) as the universal major energy source in a variety of relevant biological processes in mitochondria, bacteria a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88943662ae0c5162df0ac2076f6fabbf
https://doi.org/10.21203/rs.3.rs-146068/v1
https://doi.org/10.21203/rs.3.rs-146068/v1
Publikováno v:
Nature communications. 13(1)
F-type ATP synthases are multiprotein complexes composed of two separate coupled motors (F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3e2be91d20330d3a050b460644ad3333
https://pubmed.ncbi.nlm.nih.gov/35260553
https://pubmed.ncbi.nlm.nih.gov/35260553
Autor:
Nina Morgner, Lisa Schulz, Marius Friedrich, Rene Zangl, Kamil Hofman, Georg Manolikakes, Saad Shaaban
Publikováno v:
Tetrahedron Chem. 1:100003
Heterocyclic sulfones and sulfonamides represent important structural motives in medicinal chemistry and drug development. Therefore, efficient and reliable methods for their construction from simple building blocks are in high demand. Herein we repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::326c75d2e2c58d1dd54acd0ff7be0904
https://doi.org/10.1016/j.tchem.2021.100003
https://doi.org/10.1016/j.tchem.2021.100003
Autor:
Nina Morgner, Gunter P. Eckert, Tobias Lieblein, Maximilian Pohland, Mike Heilemann, Petra Freund, Rene Zangl, Rekha Grewal, Tina Stark, Elisabeth Kalden, Michael W. Göbel
Publikováno v:
Biochemistry. 56:4840-4849
The peptide sequence KLVFF resembles the hydrophobic core of the Aβ peptide known to form amyloid plaques in Alzheimer’s disease. Starting from its retro-inverso peptide, we have synthesized three generations of peptidomimetics. Step by step natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08714ed884b698d44540ae00780d401e
https://doi.org/10.1021/acs.biochem.7b00223
https://doi.org/10.1021/acs.biochem.7b00223