Modulation of Macropinocytosis-Mediated Internalization Decreases Ocular Toxicity of Antibody-Drug Conjugates

Autor: Pia M. Challita-Eid, Karen Morrison, Sung-Ju Moon, Rene S. Hubert, Jenny Nater, Peng Yang, Faisal Malik, Josh Snyder, Roland Luethy, Hector Aviña, Jimmy Ou, Brian A. Mendelsohn, Linnette Capo, Sher Karki, Jeffrey O. Coleman, Zhilan Zeng, Hui Zhao, Fernando Donate, Sara Gulesserian, John P. Atkinson, David R. Stover

Publikováno v: Cancer research. 78(8)

AGS-16C3F is an antibody–drug conjugate (ADC) against ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) containing the mcMMAF linker-payload currently in development for treatment of metastatic renal cell carcinoma. AGS-16C3F and other ADC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c949207f10c990a4dcf0537425c22bee
https://pubmed.ncbi.nlm.nih.gov/29382707

Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts

Autor: Rene S. Hubert, Douglas C. Saffran, Arthur B. Raitano, Owen N. Witte, Robert E. Reiter, Aya Jakobovits

Publikováno v: Proceedings of the National Academy of Sciences. 98:2658-2663

Prostate stem-cell antigen (PSCA) is a cell-surface antigen expressed in normal prostate and overexpressed in prostate cancer tissues. PSCA expression is detected in over 80% of patients with local disease, and elevated levels of PSCA are correlated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87bff04485f96b5aa04d6dcb9e548987
https://doi.org/10.1073/pnas.051624698

Industrial Production of Therapeutic Proteins: Cell Lines, Cell Culture, and Purification

Autor: Marie M. Zhu, Rene S. Hubert, Michael Mollet

Publikováno v: Handbook of Industrial Chemistry and Biotechnology ISBN: 9781461442585
Kent and Riegel’s Handbook of Industrial Chemistry and Biotechnology ISBN: 9780387278421

The biotechnology and pharmaceutical industries have seen a recent surge in the development of biological drug products manufactured from engineered mammalian cell lines. Since the hugely successful launch of human tissue plasminogen activator in 198

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a048f94577073907a85b6415688a59e
https://doi.org/10.1007/978-1-4614-4259-2_32

Single sperm analysis of the trinucleotide repeats in the Huntington's disease gene: quantification of the mutation frequency spectrum

Autor: Norman Arnheim, Marcy E. MacDonald, Margot de Young, Nancy S. Wexler, Lin Zhang, Richard H. Myers, Simon Tavaré, Esther P. Leeflang, Rene S. Hubert, Jayalakshmi Srinidhi, James F. Gusella

Publikováno v: Human molecular genetics. 4(9)

The CAG triplet repeat region of the Huntington's disease gene was amplified in 923 single sperm from three affected and two normal individuals. Average-size alleles (15-18 repeats) showed only three contraction mutations among 475 sperm (0.6%). A 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ec6c4449f63a28415cb35fa937d34c
https://pubmed.ncbi.nlm.nih.gov/8541834

Whole genome amplification from a single cell: implications for genetic analysis

Autor: K. Schmitt, Norman Arnheim, Xiangfeng Cui, Lin Zhang, Rene S. Hubert, William Navidi

We have developed an in vitro method for amplifying a large fraction of the DNA sequences present in a single haploid cell by repeated primer extensions using a mixture of 15-base random oligonucleotides. We studied 12 genetic loci and estimate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85c1fc06b5fba649f396d9c0ad7dcf86
https://europepmc.org/articles/PMC49394/