Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Rene R. Bisonette"'
Autor:
Sogole Bahmanyar, Brian E. Cathers, Mehran F. Moghaddam, Peter Worland, Lida Tehrani, Brandon Wade Whitefield, Heather Raymon, James C. Gamez, Godrej Khambatta, Julius Apuy, Samantha J. Richardson, Rene R. Bisonette, Jingjing Zhao, Graziella I. Shevlin, Deborah Mortensen, Matt Hickman, Jan Elsner, Correa Matthew D, Roy L. Harris, Sophie Perrin-Ninkovic, Rama K. Narla, Jennifer Riggs, Kimberly Elizabeth Fultz, Sabita Sankar, Patrick Papa, John Sapienza, Stacie S. Canan, Sophie X. Peng, Jason Simon Parnes, Garrick Packard, Jim Leisten, Branden Lee
Publikováno v:
Journal of Medicinal Chemistry. 58:5599-5608
We report here the synthesis and structure-activity relationship (SAR) of a novel series of triazole containing mammalian target of rapamycin (mTOR) kinase inhibitors. SAR studies examining the potency, selectivity, and PK parameters for a series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c4246303bd0bfbb72482c44adc512f
https://doi.org/10.1021/acs.jmedchem.5b00627
https://doi.org/10.1021/acs.jmedchem.5b00627
Autor:
Jason Simon Parnes, Rene R. Bisonette, Sophie Perrin-Ninkovic, Deborah Mortensen, Branden Lee, Peter Worland, James C. Gamez, Graziella I. Shevlin, Matt Hickman, Stacie S. Canan, Julius Apuy, Samantha J. Richardson, Jingjing Zhao, Godrej Khambatta, Sophie X. Peng, Jim Leisten, Garrick Packard, Correa Matthew D, Rama K. Narla, Lida Tehrani, Jennifer Riggs, Heather Raymon, Jan Elsner, Roy L. Harris, Kimberly Elizabeth Fultz, Patrick Papa, Sogole Bahmanyar, Brandon Wade Whitefield, Sabita Sankar, John Sapienza, Mehran F. Moghaddam, Brian E. Cathers
Publikováno v:
Journal of Medicinal Chemistry. 58:5323-5333
We report here the synthesis and structure-activity relationship (SAR) of a novel series of mammalian target of rapamycin (mTOR) kinase inhibitors. A series of 4,6- or 1,7-disubstituted-3,4-dihydropyrazino[2,3-b]pyrazine-2(1H)-ones were optimized for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f45fdcea6d9d36fd9f5e210e377f686
https://doi.org/10.1021/acs.jmedchem.5b00626
https://doi.org/10.1021/acs.jmedchem.5b00626
Autor:
Sabita Sankar, Matt Hickman, Roy L. Harris, Rene R. Bisonette, Gody Khambatta, Deborah Mortensen, Kimberly Elizabeth Fultz, Sophie Perrin-Ninkovic, Branden Lee, Graziella I. Shevlin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6793-6799
We report here the discovery of a novel series of selective mTOR kinase inhibitors. A series of imidazo[4,5-b]pyrazin-2-ones, represented by screening hit 1, was developed into lead compounds with excellent mTOR potency and exquisite kinase selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48462ccbb390e28889ef822cdd348fee
https://doi.org/10.1016/j.bmcl.2011.09.035
https://doi.org/10.1016/j.bmcl.2011.09.035
Autor:
Matt Hickman, Sophie X. Peng, Graziella I. Shevlin, Rama K. Narla, Jim Leisten, Rene R. Bisonette, Sophie Perrin-Ninkovic, Deborah Mortensen, Branden Lee, Gody Khambatta, Jim Gamez, Brandon Wade Whitefield, Sabita Sankar, John Sapienza, Jason Simon Parnes, Roy L. Harris, Kimberly Elizabeth Fultz
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(6)
We report here the discovery of a novel series of selective mTOR kinase inhibitors and the identification of CC214-2, a compound with demonstrated anti-tumor activity upon oral dosing in a PC3 prostate cancer xenograft model. A series of 4,6-disubsti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccdc91ae4cde7b8f11356648cc67d4d5
https://pubmed.ncbi.nlm.nih.gov/23414803
https://pubmed.ncbi.nlm.nih.gov/23414803