Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Rene Prudente"'
Autor:
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young, Ellen Ingalla, Kimberly Walter, Robert A Blake, Jim Nonomiya, Zhengyu Guan, Lorna Kategaya, Steven P Govek, Andiliy G Lai, Mehmet Kahraman, Dan Brigham, John Sensintaffar, Nhin Lu, Gang Shao, Jing Qian, Kate Grillot, Michael Moon, Rene Prudente, Eric Bischoff, Kyoung-Jin Lee, Celine Bonnefous, Karensa L Douglas, Jackaline D Julien, Johnny Y Nagasawa, Anna Aparicio, Josh Kaufman, Benjamin Haley, Jennifer M Giltnane, Ingrid E Wertz, Mark R Lackner, Michelle A Nannini, Deepak Sampath, Luis Schwarz, Henry Charles Manning, Mohammed Noor Tantawy, Carlos L Arteaga, Richard A Heyman, Peter J Rix, Lori Friedman, Nicholas D Smith, Ciara Metcalfe, Jeffrey H Hager
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/d1935c5b03e6433ea06acf491e7dc6f2
Autor:
James D Joseph, Beatrice Darimont, Wei Zhou, Alfonso Arrazate, Amy Young, Ellen Ingalla, Kimberly Walter, Robert A Blake, Jim Nonomiya, Zhengyu Guan, Lorna Kategaya, Steven P Govek, Andiliy G Lai, Mehmet Kahraman, Dan Brigham, John Sensintaffar, Nhin Lu, Gang Shao, Jing Qian, Kate Grillot, Michael Moon, Rene Prudente, Eric Bischoff, Kyoung-Jin Lee, Celine Bonnefous, Karensa L Douglas, Jackaline D Julien, Johnny Y Nagasawa, Anna Aparicio, Josh Kaufman, Benjamin Haley, Jennifer M Giltnane, Ingrid E Wertz, Mark R Lackner, Michelle A Nannini, Deepak Sampath, Luis Schwarz, Henry Charles Manning, Mohammed Noor Tantawy, Carlos L Arteaga, Richard A Heyman, Peter J Rix, Lori Friedman, Nicholas D Smith, Ciara Metcalfe, Jeffrey H Hager
Publikováno v:
eLife, Vol 5 (2016)
ER-targeted therapeutics provide valuable treatment options for patients with ER+ breast cancer, however, current relapse and mortality rates emphasize the need for improved therapeutic strategies. The recent discovery of prevalent ESR1 mutations in
Externí odkaz:
https://doaj.org/article/e0d8a246d19143f9bd877f0b6caa0659
Autor:
Sonya Zabludoff, Adam Pavlicek, B. Nelson Chau, Edmund C. Lee, Heather Estrella, Xia Yang, Scott Davis, Robin Lee, Mehran Sorourian, Eric Sung, Rene Prudente, Marlena Walls, Jian Li, Priya Karmali, Vivek Kaimal, Jill Magnus, Xinqiang Huang
Inhibition of miR-17, 20a, 20b, 93 and 106b activity by miR-17 TuD in HeLa cells as determined by luciferase reporter assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620620d9535164bdc3d9cda7eba1350d
https://doi.org/10.1158/1535-7163.22503420.v1
https://doi.org/10.1158/1535-7163.22503420.v1
Autor:
Sonya Zabludoff, Adam Pavlicek, B. Nelson Chau, Edmund C. Lee, Heather Estrella, Xia Yang, Scott Davis, Robin Lee, Mehran Sorourian, Eric Sung, Rene Prudente, Marlena Walls, Jian Li, Priya Karmali, Vivek Kaimal, Jill Magnus, Xinqiang Huang
Supplementary Methods and Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15fb576f3e2c338e8dd0fcd1627b574b
https://doi.org/10.1158/1535-7163.22503408
https://doi.org/10.1158/1535-7163.22503408
Autor:
Sonya Zabludoff, Adam Pavlicek, B. Nelson Chau, Edmund C. Lee, Heather Estrella, Xia Yang, Scott Davis, Robin Lee, Mehran Sorourian, Eric Sung, Rene Prudente, Marlena Walls, Jian Li, Priya Karmali, Vivek Kaimal, Jill Magnus, Xinqiang Huang
MetaCoreTM schematic of the TGF-β signaling pathway showing genes regulated by miR-17 TuD in Hep3B (1) and HepG2 (2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a79cd475c13d90a8f611e84481ea46d6
https://doi.org/10.1158/1535-7163.22503411.v1
https://doi.org/10.1158/1535-7163.22503411.v1
Autor:
Sonya Zabludoff, Adam Pavlicek, B. Nelson Chau, Edmund C. Lee, Heather Estrella, Xia Yang, Scott Davis, Robin Lee, Mehran Sorourian, Eric Sung, Rene Prudente, Marlena Walls, Jian Li, Priya Karmali, Vivek Kaimal, Jill Magnus, Xinqiang Huang
Expression levels of miR-17 TuD. The data are expressed as delta CT value normalized to GAPDH.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1236a40c1a2d217ae180d1b467450fc9
https://doi.org/10.1158/1535-7163.22503417
https://doi.org/10.1158/1535-7163.22503417
Autor:
Sonya Zabludoff, Adam Pavlicek, B. Nelson Chau, Edmund C. Lee, Heather Estrella, Xia Yang, Scott Davis, Robin Lee, Mehran Sorourian, Eric Sung, Rene Prudente, Marlena Walls, Jian Li, Priya Karmali, Vivek Kaimal, Jill Magnus, Xinqiang Huang
Inhibition of miR-17 family by miR-17 TuD had no effect on caspase 3/7 activity. Caspase 3/7 activity was represented as relative activity compared to NC TuD expression cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e3877bebd51652af039bb0fcafe6df
https://doi.org/10.1158/1535-7163.22503414.v1
https://doi.org/10.1158/1535-7163.22503414.v1
Autor:
Karensa L. Douglas, Kyoung-Jin Lee, Johnny Y. Nagasawa, Anna Aparicio, Nhin Lu, Andiliy G. Lai, Joshua A. Kaufman, Mehmet Kahraman, Celine Bonnefous, John Sensintaffar, Jeffrey H. Hager, James Joseph, Steven P. Govek, Peter J. Rix, Michael J. Moon, Rene Prudente, Katherine L. Grillot, Julien Jackaline D, Beatrice Darimont, Nicholas D. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:367-372
Potent estrogen receptor ligands typically contain a phenolic hydrogen-bond donor. The indazole of the selective estrogen receptor degrader (SERD) ARN-810 is believed to mimic this. Disclosed herein is the discovery of ARN-810 analogs which lack this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::652ad125c719f124722ac974d5c62830
https://doi.org/10.1016/j.bmcl.2018.12.042
https://doi.org/10.1016/j.bmcl.2018.12.042
Autor:
Celine Bonnefous, Steven P. Govek, James Joseph, Nicholas D. Smith, Kyoung-Jin Lee, John Sensintaffar, Jeffrey H. Hager, Karensa L. Douglas, Andiliy G. Lai, Daniel Brigham, Richard A. Heyman, Johnny Y. Nagasawa, Mehmet Kahraman, Nhin Liu, Jing Qian, Anna Aparicio, Josh Kaufman, Gang Shao, Rene Prudente, Peter J. Rix, Beatrice Darimont
Publikováno v:
ACS Medicinal Chemistry Letters. 10:50-55
[Image: see text] The further optimization of ER-α degradation efficacy of a series of ER modulators by refining side-chain substitution led to efficacious selective estrogen receptor degraders (SERDs). A fluoromethyl azetidine group was found to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbdff9ac5315f3b9ec912ea88414ce7d
https://doi.org/10.1021/acsmedchemlett.8b00414
https://doi.org/10.1021/acsmedchemlett.8b00414
Autor:
Daniel Brigham, Anna Aparicio, Karensa L. Douglas, Jeffrey H. Hager, Jing Qian, James Joseph, Celine Bonnefous, Gang Shao, Kate Maheu, Steven P. Govek, Richard A. Heyman, Nhin Lu, Nicholas D. Smith, Peter J. Rix, Andiliy G. Lai, Mehmet Kahraman, Johnny Y. Nagasawa, Kyoung-Jin Lee, Beatrice Darimont, John Sensintaffar, Josh Kaufman, Rene Prudente
Publikováno v:
Journal of Medicinal Chemistry. 61:7917-7928
About 75% of breast cancers are estrogen receptor alpha (ER-α) positive, and women typically initially respond well to antihormonal therapies such as tamoxifen and aromatase inhibitors, but resistance often emerges. Fulvestrant is a steroid-based, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f72964be7607fc34e509ba9d0d22b2
https://doi.org/10.1021/acs.jmedchem.8b00921
https://doi.org/10.1021/acs.jmedchem.8b00921